Abstract: Objective To implement and evaluate the effect of internet-based combining with patient-family-general practitioner group Co-management model for diabetes. Methods The management guide and flow chart were set up by series of methods including literature research, personal in-depth interviews, expert consultations and field investigations. A total of 650 patients with diabetes as experimental group were managed by internet-based technology combining with patient-family-general practitioner group Co-management. Another 650 diabetes patients were set as control group according to the 1:1 match, received conventional management. The blood glucose, health behaviors were compared between the two groups to evaluate the effect for 10 months. Results After 10 months intervention, the times of self-test blood glucose in two week in experimental group was significantly increased from 1.12±0.46 to 2.45±0.65, which was better than that of control group(P<0.001). Among the experimental group, 84% of the patients completed more than 5 health education courses. Diabetes knowledge awareness rate was increased from 48% to 88%, the difference was statistically significant(P<0.001). Some patients improved their exercise(59.8%) and diet behaviors(68.5%), and their medication compliance increased from 52.1% to 91.8%. The mean levels of fasting glucose(FBG), 2-hour postprandial blood glucose(2 hPG) of experimental group were significantly reduced from 7.41 mmol/L and 10.59 mmol/L to 6.47 mmol/L and 8.24 mmol/L. The control rate of blood glucose was increased from 36.15% to 69.08%, the difference was statistically significant(all P<0.001).The blood glucose results of experimental group was much better than that in the control group(P<0.05). Conclusion Internet-based combining with patient-family-general practitioner group Co-management model for diabetes is effective. It's worthy of further application and promotion in China to improve the management effect of diabetes.