Abstract: Objective To investigate the SCCmec genotypes and drug resistance of methicillin-resistant staphylococcus aureus(MRSA) isolated from children in Bozhou, Anhui province. Methods From December 2018 to March 2019, 89 MRSA strains isolated from 6 pediatrics wards in the People's Hospital of Bozhou were collected. The SCCmec genotypes of MRSA strains were detected by PCR. Antimicrobial susceptibility test was performed by VITEK 2 compact. Statistical analysis was performed using WHONET 5.6 software. Results Among 89 MRSA strains, SCCmec Ⅳa was the main type, accounting for 55.1%(49/89) of the total strains, followed by SCCmec type Ⅲ 12.4%(11/89), SCCmec type 1.1%(1/89), respectively. Untyped 31.4%(28/89)and SCCmecⅠ and Ⅴ type were not detected. All MRSA strains were resistant to penicillin and the resistance rates to erythromycin and clindamycin were higher, which was 87.6% and 62.9% respectively. The resistance rates to quinolones, gentamicin and trimethoprim/sulfamethoxazole were less than 10%. The resistance rates of the 49 strains of SCCmec type Ⅳa to erythromycin and clindamycin were slightly increased, which was 91.8% and 77.6%, respectively, while the resistance rate to quinolones was 4.1%, and all of the 49 strains were susceptible to gentamicin and trimethoprim/sulfamethoxazole. None of the MRSA strains were found to be resistant to vancomycin, linezolid, quinupristin/dalfopristin and tigecycline. Conclusion The prevalence of MRSA isolated from children in Bozhou was mainly SCCmec Ⅳa type strains, and they showed various degrees of resistance to different antimicrobial agents.