Abstract: Objective To explore the teaching effect of CBL combined with 3-min+task teaching method on clinical teaching in department of cardiology. Methods From January 2017 to June 2019, 60 undergraduates majored in five-year clinical medicine who interned in the department of cardiology of the fifth affiliated hospital of Xinjiang Medical University were selected as the research objects, and were randomly divided into a double-blind control group(n=30) and observation group(n=30). In the control group, the traditional teaching method was used for clinical teaching, which was conducted by general ward rounds and knowledge lectures. The observation group adopted the CBL combined with 3-min+task teaching method. The two groups were compared for their theory and manipulation examination. The teaching efficiency and satisfaction of students on clinical teaching were surveyed by using questionnaire. Results There was no significant difference between the basic knowledge and electrocardiogram reading(P>0.05), the scores of student' s cases analysis and clinical manipulative skills(including consultation techniques, cardiac physical examination, cardiopulmonary resuscitation and electrical defibrillation) in observation group were higher than those in control group(all P<0.05). The questionnaire showed that the improvement of student's professional knowledge, clinical thinking ability, clinical skills, learning interest, self-study ability, ability of solving problems and physician-patient communication ability in observation group were better than those in control group(all P<0.05), the satisfaction of teaching methods was also higher than that of the control group. Conclusion The application of CBL combined with 3-min+task teaching method can effectively stimulate students' interest in learning, improve the students' professional knowledge and manipulative skills, which is an effective and satisfying method for clinical teaching, and is worth promoting and applying in the teaching of clinical interns.