Meta analysis of the add-on effect of combined fire needle on alopecia areata
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摘要: 目的 对联合火针治疗斑秃临床研究的增加效应进行系统评价。 方法 检索中国知网(CNKI)、维普中文科技期刊数据库(VIP)、万方数据库(WF)及Pubmed数据库,检索日期至2019年1月16日,辅以手工检索,纳入评价联合火针治疗斑秃增加效应的对照试验,提取数据使用CMA软件进行统计分析。 结果 共检索到73篇文献,其中7篇对照研究符合纳入标准,累计纳入病例490例(联合火针组263例、对照组227例),比较了联合火针治疗组与常规治疗组对斑秃疗效的差异。Meta分析结果显示,在斑秃治愈率[RR=1.456,95%CI(1.171~1.810)]、显效率[RR=1.199,95%CI(1.055~1.364)]及有效率[RR=1.101,95%CI(1.041~1.165)]方面,联合火针治疗组均明显优于对照组。基础治疗为局部治疗者,增加火针治疗对治愈率、显效率和有效率均有显著提高;基础治疗为系统治疗者,火针治疗组仅对有效率有显著提高。2组不良事件发生率差异无统计学意义[RR=1.040,95%CI(0.267~4.055)],未显示严重不良事件。 结论 联合火针治疗斑秃与对照组相比疗效增加效应显著,安全性好。Abstract: Objective To systematically evaluate the add-on effect of fire needle therapy compared to conventional treatment on alopecia areata. Methods Retrieval of CNKI, VIP, WF and PubMed databases to January 16, 2019 was included in control trial to evaluate the add-on effect of combined fire needle therapy on alopecia areata. The data were collected and analyzed by CMA software. Results A total of 73 literatures were retrieved, of which 7 control studies met the inclusion criteria. There were 490 cases included(263 cases in the combined fire needle group and 227 cases in the control group). Overall, add-on therapy of combined fire needle showed consistent benefit in the cure rate[RR=1.456, 95% CI(1.171, 1.810)], apparent efficiency[RR=1.199, 95% CI(1.055, 1.364)] and effective rate[RR=1.101, 95% CI(1.041, 1.165)]. According to subgroup analysis, when the basic treatment was local therapy, fire needle showed add-on effect on increasing the fire needle treatment can significantly improve the cure rate, apparent efficiency and effective rate;when the basic treatment were systemic therapy, fire needle only showed add-on effect on effective rate. There was no significant difference in the incidence of adverse events between the two groups[RR=1.040, 95% CI(0.267, 4.055)]. No serious adverse events were found. Conclusion Compared with the control group, the add-on effect of combined fire needle on alopecia areata is significant and safe.
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Key words:
- Fire needle /
- Alopecia areata /
- Controlled study /
- Add-on effect /
- Meta analysis
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