Abstract: Objective To investigate the effect of nursing intervention on patients with liver cirrhosis accompanying esophageal and gastric varices treated by endoscopy. Methods A total of 70 cases of patients who treated by endoscopy in the First Affiliated Hospital of Anhui Medical University from October 2017 to January 2019 were selected as the objects. They were randomly divided into control group(routine nursing group) and observation group(meticulous nursing group), 35 cases in each group. Scores were compared between the two groups on the quality of life SF-36, self-rating anxiety scale(SAS), self-rating depression scale(SDS), postoperative complications and average postoperative hospitalization time. Results The scores of physical functioning, bodily pain, vitality, social role functioning, mental health and general health in the observation group were higher than those in the control group(t=3.522, 2.036, 3.748, 2.205, 2.094, 5.455, all P<0.05). The SAS score of the observation group was lower than that in the control group(t=2.879, P<0.05). The incidence of complications in the observation group(8.57%) was lower than that in the control group(28.57%), χ²=4.377, P<0.05. The duration of postoperative hospitalization of the patients in the observation group[(4.43±1.17) days] was significantly shorter than that in the control group[(6.66±1.37) days, t=7.315, P<0.01]. Conclusion For patients with liver cirrhosis combined with esophageal and gastric varices treated by endoscopy, meticulous nursing intervention can improve the quality of life, reduce the anxiety, decrease the postoperative complications and reduce hours of postoperative hospitalization. It has good application value.