Abstract: Objective To detect the serum uric acid level and fasting blood glucose level in women with common rheumatism immune disease, and to compare and analyze the relative indexes with those of normal women, so as to understand the metabolic status of patients and provide some references for clinical treatment. Methods The clinical data of 300 female patients in Fuyang People's hospital from September 2017 and September 2019 were selected, including systemic lupus erythematosus(SLE) 50 cases, lupus nephritis(LN) 50 cases, primary Sj9 gren's syndrome(pSS) 50 cases, rheumatoid arthritis(RA) 50 cases, spinal arthritis(SpA) 50 cases, and inflammatory myopathy(IIM) 50 cases. Another 50 cases of healthy women in the same period of physical examination in our hospital were randomly selected as the control group. The blood uric acid and fasting glucose level were detected. Results There were significant differences in the serum uric acid levels among 6 groups of female patients with different categories of rheumatic diseases(F=1.789, P=0.044). The LSD-t results showed that the serum uric acid level was significantly increased in LN patients compared with that in normal women(t=4.622, P<0.001), the serum uric acid level of SpA patients was lower than that of normal women(t=-2.796, P=0.006). There was no statistically significant difference in fasting glucose level between the 6 groups compared with that of the normal women(F=1.112, P=0.712). Conclusion The serum uric acid level of female LN patients is higher than that of normal women. The serum uric acid levels in female SpA patients is lower than those in normal women. There is no significant difference between the fasting blood glucose levels of women with different rheumatism and that of healthy women. Follow up should be paid attention to in LN women and the appearance of renal injury should be vigilant.