Abstract: The outbreak of COVID-19 in early 2020 is a major public health emergency with the fastest spread, the widest range of infection and the most difficult prevention and control since the founding of the People's Republic of China. The whole country has been vigorously carrying out epidemic prevention and control work. Lishui Town located in the northeast of Nanhai District, Foshan City, Guangdong Province, is close to Guangzhou, with an area of 148.28 square kilometers. Although the administrative division is only a town, the Lishui is located in the Pearl River Delta, and is an important industrial town. There are many small and medium-sized enterprises and floating population in the area, with more than 20 000 people from Hubei province. With the end of the Spring Festival, many enterprises employees returned to work and production, and many migrants personnel returned to Lishui and gather in real estate, factories, enterprises and other places, which putted great pressure on epidemic prevention and control. However, there were only 10 imported COVID-19 cases and no local COVID cases in Lishui Town as of March 5, 2020. The success in blocking the spread of the virus in the community was benefited from the long-term layout of regional grid management mode based on the "general medicine +" medical community, which was based on the support and resource allocation of the Southern Medical University and the local government through developing general medicine, coordinating the forces of the society and industry according to "medical prevention integration", aiming to provide community residents with a full range of health services throughout the life cycle. During this epidemic period, a full coverage community prevention and control system for new coronavirus pneumonia was constructed in Lishui Town, which giving full plays to the positive role of basic-level general practitioners, orderly and effectively carries out community epidemic prevention and control, actively and efficiently strengthens the management of key populations, reduces the pressure of government prevention and control, improves the efficiency of epidemic prevention and control, and provides necessary medical and health protection for the normal operation of regional economy. It is worthy of popularization and application.