Abstract: Grid management is a modern management idea that the management objects are divided into several grid units according to certain standards. By using the modern information technology and the coordination mechanism among the grid units, the information exchange between each grid can be effectively carried out, the organizational resources can be shared, and the management efficiency can be improved. Grid management can provide a set of new thinking and new methods for solving some complicated management problems. As a methodology for complex systems, Wuli-Shili-Renli(WSR) methodology is not only a methodology, but also a tool for solving complex problems. Our hospital set a grid management system of medical personnel in the medical community based on the WSR methodology during the COVID-19 epidemic. An epidemic emergency management is established, mainly including personnel hidden danger investigation and early warning mechanism, emergency information transmission and sharing mechanism, and emergency management coordination and linkage mechanism. It can fully and effectively grasp personal information of employees, understand the health and epidemiology history, and achieve information sharing, foresight and comprehensive management, which plays an important role in the prevention and control of epidemic situation in the COVID-19 epidemic prevention and control period. Grid management system is currently widely used in hospital management and other fields. In the face of major public emergencies and other events, it can be promoted in the functional communities in the region, such as schools, factories, enterprises, which is conducive to timely, effective and comprehensive grasp of everyone's information. It is a very important part of the prevention and control work, and plays an important role in the emergency management.