Abstract: Objective To explore a project-based learning model, inspire students' internal learning motivation, and improve the infectious disease community prevention and control capabilities of general practitioners of residential training. Methods Total 36 general practitioners of residential training in our hospital from February 2020 to May 2020 were selected as training subjects. All general practitioners of residential training were included in the four sub-project groups of home medical observation, centralized medical observation, popular science publicity, and online consultation for practical exploration, and senior practitioners with experience in infectious disease prevention and control evaluated their practical results. After the project was over, all students evaluated the satisfaction of this project-based learning activity. Results All general practitioners of residential training completed the project practice, and scored above 40 in each group. The problems existing in the process can be sorted out through various channels of information and can be clearly expressed. The overall satisfaction of the students with this study was 4.94±0.25, the knowledge score of the prevention and control of infectious diseases before training was 1.39±0.49, the recognition of project-based learning is 4.87±0.34, and the recognition of teacher guidance is 3.94±0.44, the willingness to participate in project-based learning again was 4.97±0.18. Conclusion Through project-based learning, the students' community prevention and control capabilities have been improved to a certain extent, and this learning method is very recognized. This research can provide a reference for the training of other skills for doctors living in the stage of resident physician training, and has a certain significance for promoting the teaching reform after graduation.