Abstract: Objective To evaluate the effect of social network-based interventions on self-management and quality of life of patients with chronic obstructive pulmonary disease(COPD). Methods We searched Chinese database(such as CNKI, Wanfang Data, CBM, VIP) and English database(The Cochrane Library, PubMed, Embase, Web of science, Proquest) for randomized clinical trials(RCTs) of social network interventions in patients with COPD. Search time was from database establishment to December 2019. Two researchers screened literature according to inclusion and exclusion criteria, extracted data and assessed the risk of bias. Then, meta-analysis and/or descriptive analysis was conduct with RevMan 5.3 software. Results A total of 10 RCTs were included in this study with enrolling 967 participants. Meta-analysis showed that the score of self-management in intervention group was higher than control group [SMD=1.89, 95% CI(0.24, 3.54), P=0.020], and the score of quality of life in control group was lower than intervention group [MD=-8.43,95% CI(-11.10,-2.77), P<0.001]. Conclusion The present evidences suggest that social network-based interventions have a positive effect on improving the self-management ability of COPD patients, as well as on improving their quality of life. Due to the limitations of study design and samples, more large sample studies are needed to make the effect more clearly.