Abstract: Objective To understand the current situation of compassion fatigue in junior nurses, and analyze its influencing factors. Methods Total 348 junior nurses from 4 third-grade class-A hospitals in Wenzhou city were selected as the research subjects using the convenience sampling from March to April 2020. The general data questionnaire, the Chinese meaning in life questionnaire, Connor-Davidson resilience scale and the health care workers' compassion fatigue scale were used. Results The total score of the meaning in life was(45.77±6.82) points. The total score of psychological resilience was(78.74±16.84) points. The score of junior nurses' compassion fatigue was(109.74±14.59) points. Univariate analysis showed that there were statistically significant differences in the scores of compassion fatigue among nurses with different ages, educational background, professional title, nursing age, night shift, and satisfaction with salary(all P<0.05). Pearson correlation analysis showed that meaning in life, psychological resilience and each dimension scores were negatively correlated with the junior nurses' compassion fatigue(all P<0.01). Multiple linear regression analysis showed that junior nurses' title, meaning in life, psychological resilience, night duty were the main influence factors of junior nurses' compassion fatigue(all P<0.05). Conclusion Junior nurses' compassion fatigue degree is higher. The title, meaning in life, psychological resilience, night duty all can affect the compassion fatigue level. Nursing managers should formulate fair and equitable professional title promotion and assessment rules, standardize the shift system, take targeted measures to improve the meaning of life and psychological resilience, alleviate the compassion fatigue of junior nurses, and improve the quality of clinical nursing service.