Abstract: Objective To detect the expression of plasma cell dendritic cell(pDCs), Toll-like receptor 7(TLR7), Toll-like receptor 9(TLR9) in labial glands of patients with primary Sj9 gren's syndrome(pSS). Methods The expression of pDC specific antigen CD123, TLR7 and TLR9 in labial gland tissues of 25 female patients diagnosed as pSS in the outpatient and inpatient departments of the Department of Rheumatology and Immunology of the Second Affiliated Hospital of Kunming Medical University from January 2018 to December 2019 were detected by immunohistochemical method. Four visual fields were randomly selected under low magnification(10×20) and analyzed by Image pro plus 6.0 software and SPSS 17.0 software. Results pDC, TLR7 and TLR9 positive cells were mainly distributed in acinar, ductal epithelial cells and lymphocyte infiltration foci in labial glands of patients with pSS. The expression of CD123⁺ pDC(3.47±0.26)% was higher than that of the normal control group(2.36±0.15)%, TLR7(2.06±0.37)% was higher than that of the normal control group(0.14±0.05)%, TLR9(1.80±0.26)% was significantly higher than that of the normal control group(0.84±0.08)%, all P<0.05. Conclusion pDC, TLR7 and TLR9 are highly expressed in labial glands(epithelial cells of glandular ducts and acini) and infiltrating foci of lymphocytes in patients with pSS.