Abstract: Objective To analyze the analgesic effect of continuous adductor canal block with lidocaine, ropivacaine and sufentanil in patients undergoing total knee arthroplasty, so as to provide a reference for clinical analgesia after total knee arthroplasty. Methods From January 2016 to January 2019, 100 patients who underwent total knee arthroplasty in Taizhou Hospital of Zhejiang Province were randomly divided into two groups according to the random number table method: femoral nerve block group(50 cases) and adductor canal block group(50 cases). The pain, knee joint range of motion and other indicators were compared between the two groups at different time points. Results The scores of resting pain at 24, 48 and 72 hours after treatment in adductor canal block group were(1.37±0.18),(0.97±0.10),(0.72±0.10) points, which were lower than those of the femoral nerve block group [(1.58±0.20),(1.12±0.24),(0.98±0.16) points], the difference was statistically significant(t=5.519, 4.079, 9.744, all P<0.001). The activity pain scores of the adductor canal block group were(2.29±0.05),(2.03±0.18),(1.67±0.25) points at 24, 48, and 72 h after treatment, all of which were lower than the femoral nerve block group [(3.28±0.26),(2.54±0.34), and(2.00±0.15) points], with statistically significant differences(t=26.440, 9.374, 8.004, all P<0.001). knee joint range of motion in adductor canal block group was(83.84±3.67)°,(100.76±6.05)° and(113.51±6.53)° at 24, 48 and 72 hours after treatment, which were higher than those in femoral nerve block group [(75.47±2.84)°,(91.74±3.87)°and(105.67±3.79)°], the difference was statistically significant(t=12.750, 8.881 and 7.333, all P<0.001). Conclusion Continuous adductor canal block with lidocaine, ropivacaine and sufentanil in total knee replacement can relieve postoperative pain with good analgesic effect.