Abstract: Objective To explore the efficacy and safety of preoperative injection of razumab in patients with diabetic retinopathy(DR) and neovascular glaucoma(NVG). Methods A total of 80 patients with DR and NVG who were treated in our hospital from July 2017 to June 2019 were selected as the study subjects, they were divided into observation group(44 cases) and control group(36 cases) according to different treatment schemes. The control group was treated with pars-plana vitrectomy(PPV), while the observation group was treated with preoperative injection of razumab on the basis of the control group. The clinical operation conditions of the two groups were compared, including the operation time, intraoperative bleeding times and electrocoagulation times; the best corrected visual acuity(BCVA) and intraocular pressure were measured and compared before operation, 1 week after PPV, 1 month after stage Ⅱ surgery, and stage Ⅱ. The macular foveal retinal thickness was measured one month after Ahmed aqueous humor drainage valve implantation. The incidence of PPV complications was compared between the two groups. Results The operation time, bleeding times and electrocoagulation times in the observation group were significantly lower than those in the control group(all P<0.05). The levels of BCVA and intraocular pressure in the observation group were significantly lower than those in the control group one week after PPV operation and one month after stage Ⅱ operation(all P<0.05). The thickness of the macular foveal retina in the observation group was(259.42±33.78) m one month after the stage Ⅱ Ahmed aqueous drainage valve implantation, and the control group was(281.64±36.97) m, the observation group was significantly lower than that in control group(P<0.05). The incidence of postoperative complications in the observation group was 9.09%, and that in the control group was 30.56%, the observation group was significantly lower than that in control group(P<0.05). Conclusion Preoperative injection of razumab has a good clinical effect on DR patients with NVG, which is conducive to the recovery of visual acuity and intraocular pressure after operation, and reduces the damage to retina, and has high safety.