Abstract: Objective To analyze the psychosocial characteristics, life and sleep quality of chronic non-atrophic gastritis(CNAG), chronic atrophic gastritis(CAG) and intestinal metaplasia(IM) patients and their related factors. Methods A total of 671 patients with chronic gastritis who visited the outpatient department of Xijing hospital from June to December 2019 were enrolled. According to biopsy pathological diagnosis, they were divided into CNAG group(136 cases), CAG group(180 cases) and IM group(355 cases). Hamilton depression scale(HAMD), Hamilton anxiety scale(HAMA), quality of life scale(SF-36), Pittsburgh sleep quality index(PSQI) and coping style(TCSQ) were used for assessment and analysis. Results The incidence rates of anxiety and depression in the IM group were significantly higher than those in the CNAG group and the CAG group(all P<0.05). The scores of all factors of the quality of life scale of the three groups were lower than the national norm scores in three groups. The scores of physiological function, body pain and general health condition of the IM group were significantly lower than those of the CNAG group and the CAG group(all P<0.05). The total score of sleep quality in both the IM group and the CAG group was significantly higher than that in the CNAG group(all P<0.05). The positive coping scores of both the CAG group and the IM group were significantly lower than those of the CNAG group(all P<0.05). The negative coping score of the IM group was significantly higher than that of the CNAG group and the CAG group(both P<0.05). Further analysis found that the patient's age, gender, education level, HP infection status and course of disease could affect the anxiety and depression incidence and sleep quality of patients with chronic gastritis, age, education level and gender may be related to the patient's quality of life. Among them, education level and age were related to changes in patients' active coping style. Conclusion With the aggravation of chronic gastritis mucosal lesions, the incidence of anxiety and depression in patients significantly increased, the quality of life and sleep quality significantly decreased, and the way of coping with things tends to be negative. It is suggested that clinical attention should be paid to the mental state, life and sleep quality of patients with chronic gastritis, and appropriate intervention should be given when necessary.