Abstract: Objective To explorer the value of quantitative contrast-enhanced ultrasound in the prediction of blunt splenic trauma. Methods A total of 86 patients who were suspected of blunt splenic trauma from January 2015 to August 2018 in our hospital were chosen and underwent CE-MDCT, CEUS and US. All the patients were divided into blunt splenic trauma group and non-blunt splenic trauma group based on CE-MDCT results. The differences of clinical information between patients were compared. The receiver operating characteristic curves(ROC) were plotted and the diagnostic efficiency of CEUS and US in predicting blunt splenic trauma were evaluated. Results They showed significantly increase in US value, AT, TTP and WT and decrease in PI in blunt splenic trauma group compared with non-blunt splenic trauma group(all P>0.05). The ROC curve showed that the AUC of AT, TTP, WT and PI in predicting blunt splenic trauma were significantly higher than US, of which the best cut-off points were AT≥8.187 s, TTP≥61.482 s, WT≥88.351 s, PI≥18.731 db. The sensitivity of AT, TTP, WT and PI in evaluating blunt splenic trauma were significantly higher than US. Conclusion Quantitative CEUS is valuable in the evaluation of blunt splenic trauma. AT≥8.187 s, TTP≥61.482 s, WT≥88.351 s and PI≥18.731 db can be used as reference indexes for spleen frustrgot injury.