Abstract: Objective To compare the clinical effect of thoracoscopic surgery(TS) on benign pulmonary nodules. Methods From July 2017 to December 2018, 130 patients with solitary benign pulmonary nodules who underwent TS were enrolled in the thoracic surgery of Hangzhou first people's Hospital for clinical observation. According to different nursing methods, they were divided into control group and observation group, 65 cases in each group. The control group received routine nursing measures, including strengthening preoperative nursing, preparing respiratory tract, observing vital signs after operation, and managing respiratory tract. The observation group was given holistic nursing intervention, focusing on emotional counseling and psychological nursing of patients in perioperative period. After the intervention, the scores of self-rating Anxiety Scale(SAS) and self-rating Depression Scale(SDS), incidence of complications, average length of stay and patient satisfaction were compared between the two groups. Results After the intervention, the SAS and SDS scores of the observation group were significantly different from those of the control group(all P<0.05). The average hospitalization time of the observation group was(7.13±2.05) days, and that of the control group was(14.05±2.23) days. The difference between the two groups was statistically significant(t=18.418, P<0.05). The total complication rate of the observation group was 4.62%(3/65) and that of the control group was 16.92%(11/65). The difference between the two groups was statistically significant(χ²=4.000, P<0.05). The satisfaction score of observation group(95.77±2.69) was higher than that of control group(80.45±2.10), t=36.193, P<0.05. Conclusion Holistic nursing can improve the negative emotions of patients with solitary pulmonary nodules treated by thoracoscopic surgery, shorten the length of hospital stay, reduce the incidence of postoperative complications, so the level of patient satisfaction is improved.