牙周炎伴2型糖尿病患者龈沟液脂联素水平与炎症反应及牙周指标的相关性研究

童熹; 丁成; 濮莉莉; 吕辰翼; 章蕾; 李小芳; 马秋君

doi:10.16766/j.cnki.issn.1674-4152.001727

牙周炎伴2型糖尿病患者龈沟液脂联素水平与炎症反应及牙周指标的相关性研究

doi: 10.16766/j.cnki.issn.1674-4152.001727

1.
金华市中心医院口腔科，浙江金华 321000
2.
杭州市第二人民医院口腔科，浙江杭州 310000

基金项目:

浙江省医药卫生科技计划项目 2019KY497

详细信息

通讯作者:
童熹，E-mail：253552842@qq.com

中图分类号: R781.42 R587.1 R446
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- 文章访问数: 219
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- PDF下载量: 3
- 被引次数: 0
出版历程
- 收稿日期: 2020-07-30
- 网络出版日期: 2022-02-19

Correlation between gingival crevicular fluid adiponectin level, inflammation and periodontal index in patients with periodontitis and type 2 diabetes

1.
Department of Stomatology, Jinhua Central Hospital, Jinhua, Zhejiang 321000, China

摘要

摘要: 目的探讨牙周炎伴2型糖尿病(type 2 diabetes，T₂DM)患者龈沟液脂联素(adiponectin，APN)水平与炎症反应、牙周指标的相关性。方法选取2018年1月—2019年12月50例健康人员作为A组，并于同期选取金华市中心医院口腔科及杭州市第二人民医院口腔科收治的50例单纯牙周炎患者作为B组，50例牙周炎伴T₂DM患者作为C组。比较3组血糖、APN、牙周指标及炎症因子水平，并采用Pearson法分析牙周炎伴T₂DM患者龈沟液APN水平与炎症因子水平、牙周指标的相关性。结果 C组龈沟液葡萄糖水平明显高于A组、B组(均P < 0.05)；B组、C组龈沟液APN水平明显低于A组(均P < 0.05)，且C组APN水平明显低于B组(P < 0.05)；B组、C组单核细胞趋化蛋白-1(MCP-1)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平明显高于A组(均P < 0.05)，且C组明显高于B组(均P < 0.05)；B组、C组菌斑指数(PLI)、出血指数(SBI)、附着丧失(AL)、探诊深度(PD)明显高于A组(均P < 0.05)，且C组明显高于B组(均P < 0.05)；牙周炎伴T₂DM患者龈沟液APN水平与MCP-1、TNF-α、IL-6、PLI、SBI、AL、PD呈负相关(r=-0.464、-0.471、-0.571、-0.319、-0.518、-0.515、-0.430，均P < 0.05)。结论 APN水平在牙周炎患者中水平上升，其水平在牙周炎伴T₂DM患者中进一步上升，且牙周炎伴T₂DM患者APN水平与其炎症反应、牙周症状密切相关。
- 牙周炎 /
- 2型糖尿病 /
- 脂联素 /
- 血糖 /
- 炎症反应
Abstract: Objective To investigate the correlation of the adiponectin (APN) level in gingival crevicular fluid, inflammation response and periodontal index in patients with periodontitis and type 2 diabetes (T₂DM). Methods Fifty healthy patients from January 2018 to December 2019 were selected as group A. At the same period, 50 patients with simple periodontitis admitted to the Department of Stomatology, Jinhua Central Hospital, and Department of Stomatology, Hangzhou Second People's Hospital, were selected as group B, and 50 patients with periodontitis and T₂DM were selected as group C. The blood glucose, APN, periodontal index and inflammatory factor level of the three groups were compared, and the correlation between the inflammatory factor level and periodontal index of the gingival crevicular fluid APN level in patients with periodontitis and T₂DM was analysed by the Pearson method. Results The blood glucose level of gingival crevicular fluid in group C was significantly higher than that in groups A and B (all P < 0.05); the APN level of gingival crevicular fluid in groups B and C was significantly lower than that in group A (all P < 0.05), and the APN level in group C was significantly lower than that in group B (P < 0.05); the levels of monocyte chemotactic protein-1 (MCP-1), tumour necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in groups B and C were significantly higher than those in group A (all P < 0.05), and group C was significantly higher than group B (all P < 0.05); plaque index (PLI), bleeding index (SBI), loss of attachment (AL) and depth of exploration (PD) in groups B and C were significantly higher than those in group A (all P < 0.05), and group C was significantly higher than group B (all P < 0.05); the level of gingival crevicular fluid APN in patients with periodontitis and T₂DM was negatively correlated with MCP-1, TNF-α, IL-6, PLI, SBI, AL and PD (r=-0.464, -0.471, -0.571, -0.319, -0.518, -0.515, -0.430, all P < 0.05). Conclusion The level of APN increases in patients with periodontitis, and its level further increases in patients with periodontitis and T₂DM, and the APN level is closely related to inflammation and periodontal symptoms in patients with periodontitis and T₂DM.
- Periodontitis /
- Type 2 diabetes /
- Adiponectin /
- Blood glucose /
- Inflammatory response

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表 1 3组一般资料比较

组别	例数	性别(例)		年龄 (x±s，岁)	BMI (x±s)	教育程度(例)			吸烟(例)
组别	例数	男性	女性	年龄 (x±s，岁)	BMI (x±s)	初中及以下	中专及高中	大专及以上	吸烟(例)
A组	50	28	22	58.73±8.24	23.56±2.58	18	20	12	15
B组	50	30	20	59.54±7.64	24.12±2.34	15	22	13	13
C组	50	26	24	60.23±8.56	23.74±2.15	19	21	10	12
统计量		0.649^a		0.424^b	0.732^b	0.873^c			0.477^a
P值		0.723		0.655	0.483	0.646			0.788
注：^a为χ²值，^b为F值，^c为Z值。

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表 2 3组龈沟液葡萄糖、APN水平比较(x±s)

组别	例数	龈沟液葡萄糖(mmol/L)	脂联素(μg/mL)
A组	50	4.05±0.56	2.56±0.67
B组	50	4.31±0.93	1.50±0.48^a
C组	50	9.37±2.09^ab	0.83±0.25^ab
F值		243.034	153.900
P值		< 0.001	< 0.001
注：与A组比较，^aP < 0.05；与B组比较，^bP < 0.05。

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表 3 3组炎症指标水平比较(x±s，μg/L)

组别	例数	MCP-1	TNF-α	IL-6
A组	50	0.78±0.20	0.67±0.15	0.63±0.18
B组	50	1.88±0.64^a	1.96±0.56^a	1.82±0.54^a
C组	50	3.32±0.90^ab	2.93±0.58^ab	2.53±0.56^ab
F值		193.230	286.423	216.800
P值		< 0.001	< 0.001	< 0.001
注：与A组比较，^aP < 0.05；与B组比较，^bP < 0.05。

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表 4 3组牙周指标比较(x±s)

组别	例数	PLI(分)	SBI(分)	AL(mm)	PD(mm)
A组	50	0.85±0.15	1.15±0.20	0.80±0.17	1.88±0.42
B组	50	1.95±0.54^a	3.23±0.64^a	3.25±0.64^a	3.95±0.84^a
C组	50	2.41±0.44^ab	3.83±0.79^ab	3.92±0.88^ab	4.51±0.93^ab
F值		189.820	276.414	264.585	164.846
P值		< 0.001	< 0.001	< 0.001	< 0.001
注：与A组比较，^aP < 0.05；与B组比较，^bP < 0.05。

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