乙酰谷酰胺与帕罗西汀治疗广泛性焦虑症的临床疗效对照研究

许雅璇; 许力; 韦道祥

doi:10.16766/j.cnki.issn.1674-4152.001787

乙酰谷酰胺与帕罗西汀治疗广泛性焦虑症的临床疗效对照研究

doi: 10.16766/j.cnki.issn.1674-4152.001787

蚌埠医学院第一附属医院神经内科，安徽蚌埠 233004

基金项目:

安徽高校人文社会科学研究 SK2018A0181

详细信息

通讯作者:
韦道祥，E-mail：weidaoxiang@sina.com

中图分类号: R749.053
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- 被引次数: 0
出版历程
- 收稿日期: 2020-09-21
- 网络出版日期: 2022-02-19

Comparative study of the clinical efficacy of acetylglutamine and paroxetine in treating generalised anxiety disorder

Department of Neurology, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

摘要

摘要: 目的研究乙酰谷酰胺与帕罗西汀治疗广泛性焦虑症(generalized anxiety disorder，GAD)的临床疗效，并进行对比分析。方法收集蚌埠医学院第一附属医院2019年3—11月收治的焦虑症患者共30例，按随机数字表法分为研究组和对照组，各15例。2组患者在一般资料如年龄、性别、病程等基本信息上差异无统计学意义, 可进行对比分析。研究组予以乙酰谷酰胺治疗，对照组予以帕罗西汀治疗，通过汉密顿焦虑量表评分分别比较2组患者在治疗7 d后、治疗14 d后的病情变化。结果对照组在治疗前、治疗7 d后、治疗14 d后的焦虑评分分别为(21.33±3.42)分、(17.40±3.38)分、(15.20±2.51)分，研究组3个时间点评分分别为(22.47±4.03)分、(16.53±3.52)分、(11.80±2.47)分，研究组较对照组在治疗14 d后焦虑程度明显缓解(P < 0.05)。对照组患者的总有效率明显低于研究组，差异有统计学意义(P=0.039)。结论乙酰谷酰胺与帕罗西汀治疗广泛性焦虑症均有明显的治疗效果，但前者抗焦虑效果优于后者，起效更快，安全可靠，更值得临床推广应用。
- 乙酰谷酰胺 /
- 帕罗西汀 /
- 广泛性焦虑症
Abstract: Objective To compare and analyse the clinical efficacy of aceglutamide and paroxetine in treating generalised anxiety disorder. Methods A total of 30 patients with anxiety disorders admitted to the First Affiliated Hospital of Bengbu Medical College from March 2019 to November 2019 were collected and divided into study group and control group by random number table method, with 15 patients per group. No statistically significant difference existed between the two groups in general information such as age, gender, course of disease, and other basic information which could be compared and analysed. Patients in the study group were treated with aceglutamide, whereas those in the control group were treated with paroxetine. Changes in the condition of patients in the two groups after 7 and 14 days of treatment were compared using Hamilton Anxiety scale scores. Results The anxiety scores of the control group before treatment, 7 days after treatment and 14 days after treatment were 21.33±3.42, 17.40±3.38 and 15.20±2.51 respectively, while those of the study group were 22.47±4.03, 16.53±3.52 and 11.80±2.47 respectively. The anxiety scores of the study group were significantly reduced compared with those of the control group (P < 0.05). The total effective rate of the control group was significantly lower than that of the study group (P=0.039). Conclusion Aceglutamide and paroxetine have obvious therapeutic effects in treating generalised anxiety disorder, but the former has better anti-anxiety effect, with faster onset, safety and reliability, which is more worthy of clinical application.
- Acetylglutamate /
- Paroxetine /
- Generalised anxiety disorder

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表 1 2组广泛性焦虑症患者治疗前后HAMA评分比较(x ±s，分)

组别	例数	治疗前	治疗7 d	治疗14 d	F值	P值
研究组	15	22.47±4.03	16.53±3.52	11.80±2.47^a	246.303	< 0.001
对照组	15	21.33±3.24	17.40±3.38	15.20±2.51^a	22.727	< 0.001
t值		-0.848	0.688	3.499
P值		0.404	0.200	0.002
注：与同组治疗前比较，^aP < 0.05。

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表 2 治疗后2组广泛性焦虑症患者临床总有效率比较[例(%)]

组别	例数	痊愈	显效	有效	无效	总有效
对照组	15	1(6.67)	1(6.67)	6(40.00)	7(46.66)	8(53.33)
研究组	15	2(13.33)	7(46.66)	5(33.34)	1(6.67)	14(93.33)
注：2组总有效率比较采用Fisher精确检验，P=0.039。

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参考文献(16)

[1]	李兆生. 甜梦胶囊联合帕罗西汀治疗女性更年期广泛性焦虑障碍临床疗效[J]. 中草药, 2017, 48(12): 2498-2501. https://www.cnki.com.cn/Article/CJFDTOTAL-ZCYO201712021.htm
[2]	周春闽, 陈建, 陈美蓉. 坦度螺酮、丁螺环酮各自联用奥氮平治疗首发精神分裂症伴焦虑比较[J]. 海峡药学, 2017, 29(1): 100-101. https://www.cnki.com.cn/Article/CJFDTOTAL-HAIX201701044.htm
[3]	王哲. 丁螺环酮联合帕罗西汀治疗焦虑症的临床效果研究[J]. 世界最新医学信息文摘, 2019, 19(14): 128-132. https://www.cnki.com.cn/Article/CJFDTOTAL-WMIA201914084.htm
[4]	黄海涛, 王龙锦, 熊健. 帕罗西汀在广泛性焦虑症治疗中的效果观察[J]. 当代医学, 2019, 25(3): 86-88. https://www.cnki.com.cn/Article/CJFDTOTAL-DDYI201903038.htm
[5]	范泽斌, 向彦琪, 陶好娟. 艾司西酞普兰和文拉法辛治疗老年焦虑症的疗效及安全性[J]. 中国老年学杂志, 2019, 39(21): 5288-5295. doi: 10.3969/j.issn.1005-9202.2019.21.047
[6]	HILDEBRANDTT M, NUNES N A, ARAŪJO W L, et al. Amino acid catabolism in plants[J]. Mol Plant, 2015, 8(11): 1563－1579. doi: 10.1016/j.molp.2015.09.005
[7]	SEN S, ROY S, BANDYOPADHYAY G, et al. γ-Aminobutyric acid is synthesized and released by the endothelium: Potential implications[J]. Circ Res, 2016, 119(5): 621-634. doi: 10.1161/CIRCRESAHA.116.308645
[8]	RAMESH S A, TYERMAN S D, XU B, et al. GABA signalling modulates plant growth by directly regulating the activity of plant-specific anion transporters[J]. Nat Commun, 2015, 6(1): 110-115. http://europepmc.org/articles/PMC4532832
[9]	NIKOLAUS S, WITTSACK H J, BEU M, et al. GABA ergic contyol of nigrostriatal and messolimbic dopamine in the rat Brain[J]. Front Behav Neurosci, 2018, 12: 38. doi: 10.3389/fnbeh.2018.00038/pdf
[10]	李鸿梅, 孙琦. 乙酰谷酰胺联合白蛋白治疗脑栓塞的临床研究[J]. 中国现代药物应用, 2015, 9(24): 109-110. https://www.cnki.com.cn/Article/CJFDTOTAL-ZWYY201524082.htm
[11]	LI D, CHEN Y G, ZHANG C J, et al. Safflower extract and aceglutamide injection promoting recovery of peripheral innervations via vascular endothelial growth factor B signaling in diabetic mice [J]. Chin Med J(Engl), 2017, 130(23): 2829-2835. http://europepmc.org/abstract/MED/29176141
[12]	吴雨恒. 关于乙酰谷酰胺注射液的临床应用研究[J]. 中西医结合心血管病电子杂志, 2019, 7(21): 23-24. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXJH201921014.htm
[13]	马奇, 李丽霞, 连和谈. 艾司西酞普兰与文拉法辛治疗老年焦虑症的临床疗效与安全性[J]. 当代临床医刊, 2016, 29(3): 2188-2189. https://www.cnki.com.cn/Article/CJFDTOTAL-GQYK201603007.htm
[14]	LIN D H, ZHANG X R, YE D Q, et al. The role of the two-pore domain potassium channel TREK-1 in the therapeutic effects of escitalopram in a rat model of poststroke depression[J]. CNS Neurosci Ther, 2015, 21(6): 504-512. http://www.onacademic.com/detail/journal_1000037485530410_6fcf.html
[15]	洪二郎, 常凤坤, 李德生, 等. 劳拉西泮对广泛性焦虑症患者的临床效果及QOL评分的影响[J]. 中国医学创新, 2020, 17(6): 47-51. https://www.cnki.com.cn/Article/CJFDTOTAL-ZYCX202006013.htm
[16]	刘肇瑞, 黄悦勤, 李占江, 等. 认知行为治疗联合药物治疗广泛性焦虑障碍的随机单盲对照试验[J]. 中国心理卫生杂志, 2019(4): 241-247. https://www.cnki.com.cn/Article/CJFDTOTAL-ZXWS201904002.htm