残喉黏膜瓣在下咽癌手术修复中的应用

柳申成; 崔忆旋; 赵报; 周兰柱; 吴俊; 王文忠

doi:10.16766/j.cnki.issn.1674-4152.001807

残喉黏膜瓣在下咽癌手术修复中的应用

doi: 10.16766/j.cnki.issn.1674-4152.001807

蚌埠医学院第一附属医院耳鼻喉头颈外科，安徽蚌埠 233000

基金项目:

国家自然科学基金 81904142

安徽省自然科学基金 KJ2019A0293

蚌埠医学院第一附属医院杰出青年科学基金 2019byyfyyq03

蚌埠医学院自然科学基金 BYTM2019010

详细信息

通讯作者:
王文忠, E-mail: 13955259039@163.com

中图分类号: R739.63 R739.65
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出版历程
- 收稿日期: 2020-08-27
- 网络出版日期: 2022-02-19

Application of residual laryngeal mucosa flap in surgical repair of hypopharyngeal carcinoma

Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

摘要

摘要: 目的探讨残喉黏膜瓣在下咽癌手术修复中的应用。方法收集2015年9月—2017年9月蚌埠医学院第一附属医院耳鼻咽喉头颈外科行残喉黏膜瓣修补下咽缺损的下咽癌修复手术患者48例。TNM分期为，T₂N₀M₀ 8例，T₂N₁M₀ 7例，T₂N₂M₀ 7例，T₃N₀M₀ 10例，T₃N₁M₀ 9例，T₃N₂M₀ 6例，T₄N₂M₀ 1例。根据肿瘤的原发位置部位选择手术入路：会厌谷、梨状窝外侧壁或尖部三种路径进入咽腔，切除范围距肿瘤1.5~2.0 cm，切缘快速冰冻检查，利用残存喉黏膜瓣进行下咽缺损修复。评估患者病情变化及身体状况，术后1个月行放疗或化疗治疗。结果 48例患者均在短期内恢复正常吞咽功能。其中3例患者于术后6 d发现局部感染和咽瘘，咽瘘＜2 cm，占6.25%(3/48)，经局部换药2周内愈合；2例患者术后出现吻合口狭窄，6.25%(2/32)，经相应扩张后好转。其中16例患者为全喉切除，术后呼吸通畅；28例患者于术后3个月内拔除气管套管，2例患者于术后6个月拔管，拔管率94%(30/32)。2例患者术后喉腔狭窄，无法拔管。2例3年内局部复发+颈部转移+远处转移(肺转移)；1例3年内局部复发+食管转移；1例患者抑郁(自行脱管)，5例失访。3年生存率为81.3%(39/48)。结论利用残喉黏膜瓣修补部分下咽癌切除术后的下咽缺损，就近取材，不增加切口、创伤不大，抗感染能力强、易成活，并发症相对较少。
- 喉咽肿瘤 /
- 喉咽缺损 /
- 黏膜修复
Abstract: Objective To explore the application of residual laryngeal mucosa flap in surgical repair of hypopharyngeal carcinoma. Methods Total 48 patients with hypopharyngeal cancer who underwent hypopharyngeal defect repair with residual laryngeal mucosal flap in the Department of Otolaryngology Head and Neck Surgery, the First Affiliated Hospital of Bengbu Medical College from September 2015 to September 2017were collected. The TNM stages of 48 patients were T₂N₀M₀ 8 cases, T₂N₁M₀ 7 cases, T₂N₂M₀ 7 cases, T₃N₀M₀ 10 cases, T₃N₁M₀ 9 cases, T₃N₂M₀ 6 cases and T₄N₂M₀ 1 cases. According to the primary location of the tumor, the surgical approaches were selected: epiglottis valley, lateral wall or tip of pyriform fossa entering the pharyngeal cavity. The resection range was 1.5-2.0 cm from the tumor. The cutting edge was quickly frozen and the residual laryngeal mucosal flap was used to repair the hypopharyngeal defect. Evaluate the changes of patients' condition and physical condition, and receive radiotherapy or chemotherapy one month after operation. Results All 48 patients recovered normal swallowing function in a short time. Local infection and pharyngeal fistula were found in 3 patients 6 days after operation. The pharyngeal fistula was less than 2 cm, accounting for 6.25% (3/48), and healed within 2 weeks after local dressing change. Anastomotic stenosis occurred in 2 patients (6.25%, 2/32) after operation, and improved after corresponding expansion. Among them, 16 patients underwent total laryngectomy and breathed smoothly after operation. Tracheal cannula was removed in 28 patients within 3 months after operation, and extubation rate was 94% (30/32) in 2 patients 6 months after operation. The laryngeal cavity of 2 patients was narrow after operation, which made it impossible to extubate. Local recurrence + cervical metastasis + distant metastasis (lung metastasis) occurred in 2 cases within 3 years. Local recurrence + esophageal metastasis occurred in 1 case within 3 years. One patient was depressed (self-catheter removal), and 5 patients lost follow-up. The 3-year survival rate was 81.3% (39/48). Conclusion Repairing hypopharyngeal defect after partial hypopharyngeal cancer resection with residual laryngeal mucosa flap has the advantages of taking materials nearby, not increasing incision, less trauma, strong anti-infection ability, easy survival and relatively few complications.
- Laryngopharyngeal Tumor /
- Laryngopharyngeal defect /
- Mucosal repair

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参考文献(18)

[1]	潘青海, 郭星. 下咽癌修复方式及选择[J]. 国际耳鼻咽喉头颈外科杂志, 2018, 42(4): 204-208. doi: 10.3760/cma.j.issn.1673-4106.2018.04.004
[2]	NEWMAN J R, CONNOLLY T M, ILLING E A, et al. Survival trends in hypopharyngeal cancer: a population-based review[J]. Laryngoscope, 2015, 125(3): 624-629. doi: 10.1002/lary.24915
[3]	Pracy P, Loughran S, Good J, et al. Hypopharyngeal cancer: United Kingdom National multidisciplinary guidelines[J]. J Laryngol Otol, 2016, 130(S2): S104-S110. doi: 10.1017/S0022215116000529
[4]	KWON D I, MILES B A. Education Committee of the American Head and Neck Society(AHNS). Hypopharyngeal carcinoma: Do you know your guidelines?[J]. Head Neck, 2019, 41(3): 569-576. doi: 10.1002/hed.24752
[5]	徐伟, 吕正华, 洒娜, 等. 264例下咽癌治疗与预后分析[J]. 中华耳鼻咽喉头颈外科杂志, 2018, 53(5): 346-351. doi: 10.3760/cma.j.issn.1673-0860.2018.05.004
[6]	CHOI Y, BIN-MANIE M, ROH J L, et al. Metastatic lymph node burden predictive of survival in patients undergoing primary surgery for laryngeal and hypopharyngeal cancer[J]. J Cancer Res Clin Oncol, 2019, 145(10): 2565-2572. doi: 10.1007/s00432-019-02990-4
[7]	刘文中, 李振东, 李树春, 等. 下咽癌的颈部淋巴结转移顺序[J]. 中华肿瘤杂志, 2017, 39(12): 937-941. doi: 10.3760/cma.j.issn.0253-3766.2017.12.011
[8]	Yeh D H, Tam S, Fung K, et al. Transoral robotic surgery vs. radiotherapy for management of oropharyngeal squamous cell carcinoma - A systematic review of the literature[J]. Eur J Surg Oncol, 2015, 41(12): 1603-1614. doi: 10.1016/j.ejso.2015.09.007
[9]	宋富存, 杨阳. 下咽癌外科手术治疗的研究进展[J]. 山东医药, 2020, 60(13): 104-106. doi: 10.3969/j.issn.1002-266X.2020.13.030
[10]	MEULEMANS J, DELAERE P, POORTEN V V. Primary treatment of T1-T2 hypopharyngeal cancer: changing paradigms[J]. Adv Otorhinolaryngol, 2019, 83: 54-65. http://www.ncbi.nlm.nih.gov/pubmed/30943502
[11]	HABIB A. Management of advanced hypopharyngeal carcinoma: systematic review of survival following surgical and non-surgical treatments[J]. J Laryngol Otol, 2018, 132(5): 385-400. doi: 10.1017/S0022215118000555
[12]	GARNEAU J C, BAKST R L, MILES B A. Hypopharyngeal cancer: A state of the art review[J]. Oral Oncol, 2018, 86: 244-250. doi: 10.1016/j.oraloncology.2018.09.025
[13]	PARK S I, CHOI S Y, BAEK C H, et al. Comparisons of clinical and functional outcomes of different reconstructive methods for the hypopharyngeal defect[J]. Oral Oncol, 2019, 94: 26-31. doi: 10.1016/j.oraloncology.2019.05.003
[14]	KI S H, CHOI J H, SIM S H. Reconstructive trends in post-ablation patients with esophagus and hypopharynx defect[J]. Arch Craniofac Surg, 2015, 16(3): 105-113. doi: 10.7181/acfs.2015.16.3.105
[15]	LUCIONI M, LIONELLO M, SALIS G, et al. Bocca's hemipharyngo-total laryngectomy for hypopharyngeal carcinoma to avoid reconstruction with a pedicled flap[J]. Head Neck, 2018, 40(7): 1476-1482. doi: 10.1002/hed.25124
[16]	于萍, 李佳原, 杨晓菊, 等. 下咽鳞状细胞癌根治术后患者随访分析及生活质量调查[J]. 中国医药, 2019, 14(7): 1086-1090. doi: 10.3760/j.issn.1673-4777.2019.07.032
[17]	邬振华, 沈志森, 成立新, 等. 保留咽喉功能的下咽癌手术分析[J]. 中华全科医学, 2015, 13(4): 559-561. https://www.cnki.com.cn/Article/CJFDTOTAL-SYQY201504016.htm
[18]	DO S B, CHUNG C H, CHANG Y J, et al. Risk factors of and treatments for pharyngocutaneous fistula occurring after oropharynx and hypopharynx reconstruction[J]. Arch Plast Surg, 2017, 44(6): 530-538. doi: 10.5999/aps.2017.00906