颅脑损伤后患者血清神经元特异性烯醇化酶与S100B蛋白的动态性变化及意义

梁炯芳; 高峰平; 刘克洪

doi:10.16766/j.cnki.issn.1674-4152.001930

颅脑损伤后患者血清神经元特异性烯醇化酶与S100B蛋白的动态性变化及意义

doi: 10.16766/j.cnki.issn.1674-4152.001930

1.
武警浙江省总队医院检验科，浙江杭州 310000
2.
武警浙江省总队医院康复中心，浙江杭州 310000

基金项目:

浙江省医药卫生科技计划项目 2020KY776

详细信息

通讯作者:
梁炯芳，E-mail: 13175317645@163.com

中图分类号: R651.15 R446.6
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- 文章访问数: 542
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- PDF下载量: 5
- 被引次数: 0
出版历程
- 收稿日期: 2020-05-22
- 网络出版日期: 2022-02-16

Dynamic changes and significance of serum NSE and S100B protein in patients with craniocerebral injury

1.
Department of Clinical Laboratory of Zhejiang General Hospital of Armed Police, Hangzhou, Zhejiang 310000, China

摘要

摘要: 目的探讨颅脑损伤后血清神经元特异性烯醇化酶(neuron-specific enolase，NSE)与S100B蛋白水平的动态性变化规律及临床意义。方法选取武警浙江省总队医院急诊科2018年1月—2019年12月接收的105例颅脑损伤患者为研究对象，按格拉斯哥评分分为轻度组(30例)、中度组(45例)和重度组(30例)，另选同期健康体检者30例作为对照组。动态监测并统计分析患者颅脑损伤后血清NSE与S100B蛋白数据。结果重度组、中度组、轻度组、对照组4组血清NSE与S100B蛋白水平分别为(34.51±5.39)μg/L、(19.31±2.72)μg/L、(13.68±3.02)μg/L、(6.11±2.35)μg/L与(2.29±0.28)μg/L、(1.47±0.15)μg/L、(0.81±0.18)μg/L、(0.32±0.09)μg/L，F=357.010，653.126，均P < 0.001；各组同时间点血清NSE与S100B蛋白比较差异有统计学意义(均P < 0.05)；血清NSE与S100B组间及组内不同时点两两比较差异均有统计学意义(均P < 0.05)。结论血清NSE与S100B蛋白水平能够动态性地反映急性颅脑损伤的病情进展，对病情分级修正、制定治疗方案及评估预后均有重要的临床指导意义。
- 颅脑损伤 /
- 神经元特异性烯醇化酶 /
- S100B蛋白 /
- 动态监测
Abstract: Objective To explore the dynamic changes and clinical significance of serum NSE and S100B protein levels after craniocerebral injury. Methods A total of 105 patients with craniocerebral injury received by the Emergency Department of Zhejiang General Hospital of Armed Police from January 2018 to December 2019 were selected as the study objects. According to Glasgow's score, they were divided into mild group (n=30), moderate group (n=45) and severe group (n=30). Another 30 healthy people in the same period were selected as the control group. Dynamic monitoring and statistical analysis of serum NSE and S100B protein data after head injury were conducted. Results The serum NSE and S100B protein levels among the four groups were (34.51±5.39) μg/L, (19.31±2.72) μg/L, (13.68±3.02) μg/L, (6.11±2.35) μg/L and (2.29±0.28) μg/L, (1.47±0.15) μg/L, (0.81±0.18) μg/L, (0.32±0.09) μg/L (F=357.010, 653.126, all P < 0.001)respectively. For each group at the same time, the difference in serum NSE and S100B protein was statistically significant (all P < 0.05). The differences in serum NSE and S100B between groups within the group and at different time points were statistically significant (all P < 0.05). Conclusion Serum NSE and S100B protein levels can dynamically reflect the progress of acute craniocerebral injury a which have important clinical guiding significance for the revision of the disease disease classification, formulation of treatment plans assessment of prognosis.
- Craniocerebral injury /
- Neuron-specific enolase /
- S100B protein /
- Dynamic Monitoring

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表 1 4组血清NSE与S100B蛋白水平的比较(x±s，μg/L)

组别	例数	NSE	S100B蛋白
重度组	30	34.51±5.39^a	2.29±0.28^a
中度组	45	19.31±2.72^a	1.47±0.15^a
轻度组	30	13.68±3.02^a	0.81±0.18^a
对照组	30	6.11±2.35	0.32±0.09
F值		357.010	653.126
P值		< 0.001	< 0.001
注：与对照组比较，^aP < 0.05。

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表 2 不同组别各时段血清NSE水平动态变化的比较(x±s，μg/L)

组别	例数	12 h	24 h	3 d	7 d	14 d	F值	P值
重度组	30	31.43±5.11^ab	34.51±5.39^ab	38.67±7.30^ab	27.79±6.39^ab	24.45±6.93^ab	23.539	< 0.001
中度组	45	17.27±2.55^a	19.31±2.72^a	17.05±2.23^a	12.65±1.20^a	9.71±0.88^a	163.355	< 0.001
轻度组	30	10.97±3.07	13.68±3.02	12.26±2.28	9.75±2.77	8.66±2.64	15.424	< 0.001
F值		258.599	252.666	327.130	183.673	154.814
P值		< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
注：与轻度组比较，^aP < 0.05；与中度组比较，^bP < 0.05。

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表 3 不同组别间各时点血清S100B蛋白水平动态变化的比较(x±s，μg/L)

组别	例数	12 h	24 h	3 d	7 d	14 d	F值	P值
重度组	30	2.07±0.23^ab	2.29±0.28^ab	1.88±0.19^ab	1.42±0.27^ab	1.04±0.15^ab	146.033	< 0.001
中度组	45	1.32±0.13^a	1.47±0.15^a	0.93±0.13^a	0.58±0.09	0.58±0.08^a	359.174	< 0.001
轻度组	30	0.71±0.14	0.81±0.18	0.66±0.17	0.49±0.15	0.44±0.14	28.988	< 0.001
F值		499.410	400.659	490.842	270.915	205.639
P值		< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
注：与轻度组比较，^aP < 0.05；与中度组比较，^bP < 0.05。

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