MicroRNA-429在妇科恶性肿瘤中的研究进展

李栗扬; 徐鹏; 王蓓蒂; 高爽; 郭钰; 匡野

doi:10.16766/j.cnki.issn.1674-4152.001973

MicroRNA-429在妇科恶性肿瘤中的研究进展

doi: 10.16766/j.cnki.issn.1674-4152.001973

哈尔滨医科大学附属第二医院妇产科，黑龙江哈尔滨 150086

基金项目:

吴阶平医学基金会临床科研课题项目 320675018061

详细信息

通讯作者:
匡野, E-mail: kuangye-blue@163.com

中图分类号: R737.3 R730
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- 文章访问数: 339
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- 被引次数: 0
出版历程
- 收稿日期: 2020-08-08
- 网络出版日期: 2022-02-16

Research progress of MicroRNA-429 in gynecological malignant tumors

Department of Gynecology and Obstetrics, the Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150086, China

摘要

摘要: 妇科恶性肿瘤是威胁女性健康的难题，早期诊断及治疗对于其预后来说意义重大。微小核糖核酸(microRNA, miRNA)是参与细胞转录后调控的小型非编码RNA，在细胞正常生理过程及肿瘤发生发展中起关键作用。MicroRNA-429(miR-429)可抑制相关转录遏制物锌指E盒结合同源框1(Zinc E-box-binding homobox 1, ZEB1)和ZEB2的表达影响肿瘤的进展及转移，并通过调控Slug基因的表达，影响E-钙黏蛋白和Snail蛋白等的表达，进而调控肿瘤中的上皮间质转化(epithelial-mesenchymal transition, EMT)，影响着肿瘤的迁移侵袭、预后以及药物敏感性。miR-429在卵巢癌(ovarian cancer)中起到肿瘤促进作用且不利于预后，但其低表达与患者生存率低相关，并且在卵巢癌腹水中发现了miR-429的差异表达，具有潜在临床诊断意义；在宫颈癌(cervical cancer)中起到肿瘤抑制作用；在子宫内膜癌(endometrial cancer)中起到肿瘤促进作用，并且可能具有潜在的诊断价值。现将关于miR-429及其在妇科恶性肿瘤中作用的相关文献进行综述，结合肿瘤发生、侵袭等多方面因素进行讨论，综合分析miR-429在妇科恶性肿瘤的意义，并为进一步研究其在临床应用中的意义提供参考。
- 微小核糖核酸-429 /
- 上皮-间质转化 /
- 卵巢癌 /
- 宫颈癌 /
- 子宫内膜癌
Abstract: Gynecological malignant tumors is a problem that threatens women's health, of which early diagnosis and treatment are of great significance to the prognosis. MicroRNA (miRNA) is a small non-coding RNA involved in post-transcriptional regulation of cells, which plays a key role in the normal physiological processes of cells and the development of tumors. MicroRNA-429 (miR-429) can inhibit the expression of zinc E-box-binding homobox 1 (ZEB1) and ZEB2, which affects tumor progression and metastasis, and regulates Slug Gene expression in order to affects the expression of E-cadherin and Snail protein, and regulates the epithelial-mesenchymal transition (EMT) in tumors, which affects tumor migration, invasion, prognosis, and drug sensitivity. MiR-429 plays a tumor-promoting role in ovarian cancer and is not conducive to the prognosis, but its low expression is associated with low patient survival rates, and the differential expression of miR-429 was found in the ascites of ovarian cancer patients, which has potential clinical diagnostic significance. It plays a role in tumor suppression in cervical cancer role; plays a tumor-promoting role in endometrial cancer, and may have potential diagnostic value in endometrial cancer.The related literature on miR-429 and it's role in gynecological malignancies is reviewed, combined with tumor occurrence, invasion and other factors to discuss, comprehensively analyze the significance of miR-429 in gynecological malignancies, and for the further study significance in clinical application provides reference.
- MicroRNA-429 /
- Epithelial-mesenchymal transition (EMT) /
- Ovarian cancer /
- Cervical cancer /
- Endometrial cancer

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