慢性阻塞性肺疾病患者CAT评分与肺功能及血气分析等指标的相关性分析

祁玉凤; 邵强; 沈兵

doi:10.16766/j.cnki.issn.1674-4152.002097

慢性阻塞性肺疾病患者CAT评分与肺功能及血气分析等指标的相关性分析

doi: 10.16766/j.cnki.issn.1674-4152.002097

祁玉凤¹,
邵强¹,
沈兵^2, ,

1.
六安市人民医院呼吸内科，安徽六安 237000
2.
安徽医科大学基础医学院生理学教研室，安徽合肥 230032

基金项目:

国家自然科学基金项目 81570403

详细信息

通讯作者:
沈兵，E-mail：shenbing@ahmu.edu.cn

中图分类号: R563.8 R446.1
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- 文章访问数: 154
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- PDF下载量: 7
- 被引次数: 0
出版历程
- 收稿日期: 2020-06-21
- 网络出版日期: 2022-02-15

Correlation analysis of CAT score with lung function and blood gas analysis in patients with chronic obstructive pulmonary disease

1.
Department of Respiratory Medicine, Lu'an People's Hospital, Lu'an, Anhui 237000, China

摘要

摘要: 目的探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease，COPD，以下简称慢阻肺)患者肺功能、血气分析、肺动脉收缩压与慢性阻塞性肺疾病评估测试(COPD assessment test，CAT)评分的关系。方法将六安市人民医院呼吸内科2019年9—12月收治的106例COPD患者按照CAT评分法进行疾病状态评定，分为病情轻微组(11例)、中等组(28例)、严重组(41例)、非常严重组(26例)，比较不同疾病状态下COPD患者的肺功能，包括第1秒用力呼气容积(forced expiratory volume in one second，FEV1)、一秒率[FEV1/用力肺活量(forced vital capacity，FVC)]、呼气流量峰值(peak expiratory flow，PEF), 血气分析[氧分压(PaO₂)、二氧化碳分压(PaCO₂)], 肺动脉收缩压(systolic pulmonary artery pressure, sPAP)的差异，探讨各指标与CAT评分的相关性。结果 CAT评分越低的患者，肺功能各项指标(FEV1、FEV1/FVC、PEF)越高(均P < 0.05)；患者CAT评分越低，PaO₂越高，PaCO₂越低(均P < 0.05)，sPAP也越低(P < 0.05)；尤其在CAT评分>20分的患者，上述差异尤其明显。Pearson相关分析显示，FEV1、FEV1/FVC、PEF、PaO₂与CAT评分呈负相关，PaCO₂、sPAP与CAT评分呈正相关。结论 COPD患者的CAT评分与肺功能、肺动脉收缩压、血气分析指标之间存在相关性，说明CAT评分可以有效预测COPD患者的换气和通气功能障碍，评价患者的肺功能情况。
- 慢性阻塞性肺疾病 /
- 肺功能 /
- 血气分析 /
- 肺动脉收缩压 /
- 慢性阻塞性肺疾病评估测试
Abstract: Objective To investigate the relationship between pulmonary function, blood gas analysis, pulmonary systolic pressure and CAT score in patients with chronic obstructive pulmonary disease (COPD). Methods Total 106 patients with COPD admitted to the Department of Perspiratory Medicine of Lu'an People's Hospital from September to December 2019 were classified into mild group (11 cases), moderate group (28 cases), severe group (41 cases) and very severe group (26 cases) according to CAT score. The pulmonary function of COPD patients in different disease states, including FEV1, FVC, PEF, PaO₂, PaCO₂, and sPAP were compared, and the correlation between each index and CAT score was discussed. Results The lower the cat score, the lung function indexes were higher (FEV1, FEV1/FVC, PEF) (all P < 0.05); The lower cat score was, the PaO₂ was higher, the PaCO₂ was lower (all P < 0.05), and the sPAP was lower (P < 0.05); Especially in patients with cat score >20, the above differences were particularly significant. Pearson correlation analysis shown that FEV1%, FEV1/FVC, PEF% and PaO₂ were negatively correlated with CAT score, while PaCO₂ and sPAP were positively correlated with CAT score. Conclusion The CAT score of COPD patients was correlated with pulmonary function, pulmonary artery systolic pressure and blood gas analysis. It is proved that CAT score can effectively predict the air exchange dysfunction and ventilation dysfunction of COPD patients, and evaluate the pulmonary function of COPD patients.
- Chronic obstructive pulmonary disease /
- Lung function /
- Blood gas analysis /
- Right ventricular pressure /
- The COPD assessment test

HTML全文

表 1 4组COPD患者各指标比较(x±s)

组别	例数	CAT评分(分)	FEV1(%)	FEV1/FVC	PEF(%)	PaO₂(mm Hg)	PaCO₂(mm Hg)	sPAP(mm Hg)
Ⅰ组	11	8.5±3.4	80.5±5.3	63.4±6.4	71.1±19.5	75.4±7.5	40.4±6.6	22.5±3.9
Ⅱ组	28	16.6±6.6a	56.7±7.6^a	53.3±7.3^a	52.3±9.8^a	68.3±5.5^a	43.7±7.8	28.4±4.6^ab
Ⅲ组	41	23.6±5.8^ab	42.6±6.4^ab	48.2±9.1^ab	38.3±11.5^ab	59.3±7.1^ab	46.1±6.9^a	37.4±4.6^ab
Ⅳ组	26	31.7±8.3^abc	30.4±3.3^abc	32.3±5.4^abc	29.4±7.4^abc	51.6±6.6^abc	54.3±5.6^abc	39.6±5.7^ab
F值		35.091	207.840	56.240	43.800	46.753	15.704	51.701
P值		0.012	0.023	0.031	0.015	0.026	0.033	0.041
注：与Ⅰ组比较，^aP < 0.05；与Ⅱ组比较，^bP < 0.05；与Ⅲ组比较，^cP < 0.05。

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表 2 COPD患者肺功能、血气分析、肺动脉压与CAT评分的相关性分析

统计量	FEV1(%)	FEV1/FVC	PEF(%)	PaO₂(mm Hg)	PaCO₂(mm Hg)	sPAP(mm Hg)
r值	-0.470	-0.520	-0.360	-0.490	0.570	0.420
P值	0.034	< 0.001	0.032	0.044	< 0.001	0.033

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