网织红细胞参数及未成熟粒细胞相对值在不良妊娠结局中的预测价值

吴秀继; 王永卿; 邱梅花

doi:10.16766/j.cnki.issn.1674-4152.002152

网织红细胞参数及未成熟粒细胞相对值在不良妊娠结局中的预测价值

doi: 10.16766/j.cnki.issn.1674-4152.002152

中南大学湘雅医学院附属海口医院检验科，海南海口 570208

基金项目:

海南省卫生计生行业科研项目 18A200020

详细信息

通讯作者:
吴秀继，E-mail: 260546952@qq.com

中图分类号: R446.11 R714.2
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- 文章访问数: 137
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- 被引次数: 0
出版历程
- 收稿日期: 2020-07-15
- 网络出版日期: 2022-02-15

Predictive value of reticulocyte parameters and relative value of immature granulocytes in adverse pregnancy outcome

Department of Clinical Laboratory, Affiliated Haikou Hospital of Xiangya Medical College, Central South University, Haikou, Hainan 570208, China

摘要

摘要: 目的探讨网织红细胞参数及未成熟粒细胞对孕妇不良妊娠结局的预测价值。方法选取100例非妊娠妇女、300例正常妊娠妇女和201例不良妊娠妇女分成3组。采用日本SysmexXN-9000全自动血细胞分析仪检测网织红细胞百分比(reticulocyte percentage，Ret%)、未成熟网织红细胞指数(immature reticulocyte fraction，IRF)、网织红细胞血红蛋白(reticulocyte hemoglobin，Ret-He)、未成熟粒细胞(immature granulocyte)的相对值(%IG)及血红蛋白(hemoglobin，Hb)，分组进行比较分析。同时通过ROC曲线探讨网织红细胞参数及未成熟粒细胞相对值对孕妇不良妊娠结局的预测价值。结果与非妊娠组比较，不良妊娠组Hb、Ret-He均明显降低, IRF升高(P < 0.05)；正常妊娠组Hb明显降低，Ret%、IRF、%IG明显升高(P < 0.05)。与正常妊娠组比较，不良妊娠组Hb、Ret%、IRF、Ret-He、%IG均明显降低(P < 0.05)。Ret%、IRF、Ret-He及%IG的ROC曲线下面积(AUC)依次为0.611、0.619、0.727、0.821，最佳预测cut-off值依次为1.695、14.100、32.450、1.350，灵敏度依次为0.814、0.833、0.502、0.671，特异度依次为0.375、0.667、0.875、0.896。结论 Ret%、IRF、Ret-He、%IG与不良妊娠结局的发生有关，且%IG预测不良妊娠结局的发生的特异性最大，而IRF的灵敏性最高。网织红细胞参数联合未成熟粒细胞相对值的检测对预测孕妇不良妊娠结局有一定的价值。
- 不良妊娠结局 /
- 网织红细胞参数 /
- 未成熟粒细胞
Abstract: Objective To investigate the predictive value of reticulocyte parameters and immature granulocytes in pregnant women with adverse pregnancy outcomes. Methods A total of 100 non-pregnant women, 300 normal pregnant women and 201 unhealthy pregnant women were divided into three groups. The reticulocyte percentage (Ret%), immature reticulocyte index (IRF), reticulocyte haemoglobin (Ret-He), and relative value (%IG) of immature granulocytes and haemoglobin (Hb) were detected by XN-9000 automatic haematology analyser (Sysmex, Japan). The ROC curve was used to explore the predictive value of reticulocyte parameters and relative value of immature granulocytes for adverse pregnancy outcomes of pregnant women. Results Compared with the non-pregnancy group, the unhealthy pregnant women group had significantly reduced Hb and Ret-He and increased IRF (P < 0.05), whilst the normal pregnancy group had significantly reduced Hb and significantly increased Ret%, IRF and %IG (P < 0.05). Compared with the normal pregnancy group, the unhealthy pregnant women group had significantly reduced Hb, Ret%, IRF, Ret-He and %IG (P < 0.05). The areas under the ROC curve of Ret%, IRF, Ret-He and %IG were 0.611, 0.619, 0.727 and 0.821, respectively. The best predicted cut-off values were 1.695, 14.100, 32.450 and 1.350. The sensitivity values were 0.814, 0.833, 0.502 and 0.671, whereas the specificity values were 0.375, 0.667, 0.875 and 0.896. Conclusion The Ret%, IRF, Ret-He and %IG are related to the occurrence of adverse pregnancy outcomes. The %IG predicts the occurrence of adverse pregnancy outcomes with the greatest specificity, whilst IRF has the highest sensitivity. Reticulocyte parameters combined with the detection of the relative value of immature granulocytes have certain value in predicting the adverse pregnancy outcomes of pregnant women.
- Adverse pregnancy outcomes /
- Reticulocyte parameters /
- Immature granulocytes

HTML全文

图 1 Ret%、IRF、Ret-He及%IG对不良妊娠结局的预测

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表 1 各组网织红细胞参数及Hb、%IG的比较(x±s)

组别	例数	Hb(g/L)	Ret%	IRF	Ret-He(pg)	%IG
非妊娠组	100	134.00±7.44	1.76±0.50	10.76±4.09	32.40±1.20	0.78±0.29
正常妊娠组	300	121.00±7.98^a	2.26±0.60^a	21.07±7.18^a	32.25±2.40	2.12±0.97^a
不良妊娠组	201	113.00±16.16^ab	1.89±0.90^b	13.53±10.93^ab	27.86±3.69^ab	0.85±0.68^b
F值		77.183	24.470	79.963	21.407	24.016
P值		< 0.001	< 0.001	< 0.001	< 0.001	< 0.001
注：与非妊娠组比较，^aP < 0.05；与正常妊娠组比较，^bP < 0.05。

下载: 导出CSV

表 2 IG%与网织红细胞参数的相关性分析

统计量	Ret%	IRF	Ret-He(pg)
r值	0.321	0.531	-0.416
P值	< 0.001	< 0.001	< 0.001

下载: 导出CSV

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