安徽省亳州市11名未成年人新型冠状病毒肺炎的感染特征分析

赵锋; 孙方; 魏广友; 何宏亮

doi:10.16766/j.cnki.issn.1674-4152.002369

安徽省亳州市11名未成年人新型冠状病毒肺炎的感染特征分析

doi: 10.16766/j.cnki.issn.1674-4152.002369

赵锋¹,
孙方^2, ,,
魏广友³,
何宏亮⁴

1.
亳州市人民医院儿童保健门诊，安徽亳州 236800
2.
亳州市人民医院医务部
3.
亳州市人民医院儿科
4.
中国科学技术大学附属第一医院感染病科，安徽合肥 230031

基金项目:

中国博士后科学基金资助项目 2020M670084ZX

详细信息

通讯作者:
孙方，E-mail：625520029@qq.com

中图分类号: R563.1
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- 文章访问数: 137
- HTML全文浏览量: 59
- PDF下载量: 1
- 被引次数: 0
出版历程
- 收稿日期: 2021-04-12
- 网络出版日期: 2022-08-13

Infection characteristics of 11 juvenile cases of COVID-19 in BoZhou City, Anhui Province

1.
Children Preventive Health Care Clinic, Bozhou People's Hospital, Bozhou, Anhui 236800, China

摘要

摘要: 目的研究安徽省亳州市新型冠状病毒肺炎(COVID-19)0~17岁未成年人患者的流行病学特征及临床特点。方法本项回顾性研究纳入了11例安徽省亳州市2020年1月24日—2月12日收治的所有未成年人确诊病例，并进行流行病学、临床、放射学特征及实验室数据分析。结果 11名COVID-19未成年人患者年龄中位数为10.54(7.50, 13.00)岁，其中男6例，女5例。所有患者均经RT-PCR检测到新型冠状病毒(SARS-Cov-2)，均至少有1名家人感染了SARS-Cov-2。4例(36.3%)患者出现发热，8例(72.7%)患者出现轻度上呼吸道感染症状，包括2例(18.2%)咳嗽，1例(9.1%)肌肉疼痛，2例(18.2%)咽喉痛，4例(36.4%)出现鼻塞、流涕，1例(9.1%)在确诊COVID-19前1~2 d表现出明显的胃肠道症状等临床表现。8例患者(72.7%)出现淋巴细胞计数减少，9例(81.8%)患者的C反应蛋白升高，3例(27.2%)患者的ALT和AST升高，4例患者(36.4%)的白细胞计数正常。影像学检查显示，3例(27.2%)患者出现双侧肺炎，5例(45.5%)患者表现为多发性斑点和磨玻璃样特征。结论与成人相比，目前未成年人病例不多，相关研究还不充足，以上资料为本次疫情的有效防控和精准救治提供了宝贵的指导意见。
- 未成年人 /
- 新型冠状病毒肺炎 /
- 防控
Abstract: Objective To study the epidemiological and clinical characteristics of juvenile patients with coronavirus disease 2019 (COVID-19) in BoZhou City, Anhui Province. Methods We conducted a retrospective study focusing on 11 juvenile patients diagnosed with COVID-19 in BoZhou City, Anhui Province from 24 January 2020 to 12 February 2020. Epidemiological, demographic, clinical, laboratory, radiological and treatment data were collected and analysed. Results Amongst the hospitalised juvenile patients with COVID-19, the median age was 10.54(7.5, 13.0) years, and 6(54.5%) were male. All 11 patients were detected by real-time RT-PCR, and at least 1 family members were infected with COVID-19. Patients had clinical manifestations of fever [4(36.3)% patients], mild upper respiratory tract symptoms [8(72.7%) patients], cough [2(18.2%) patients], muscle ache [1(9.1%) patients], sore throat [2(18.2%) patients] and nasal congestion [4(36.4%) patients]. One patient (9.1%) showed significant gastrointestinal symptoms and other clinical manifestations 1-2 days before the diagnosis of COVID-19. Eight patients (72.7%) had decreased lymphocyte counts, 9(81.8%) had elevated c-reactive protein levels, 3(27.2%) had elevated ALT and AST, and 4(36.4%) had normal white blood cell counts. According to imaging examination, 3(27.2%) patients showed bilateral pneumonia, and 5(45.5%) patients showed multiple mottling and ground-glass opacity. Conclusion Compared with adults, there are not many cases of juvenile patients, and relevant studies are insufficient. The above information provides valuable guidance for the effective management and accurate treatment of this disease.
- Juvenile /
- Coronavirus disease 2019 /
- Prevention and control

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图 1 患者胸部CT扫描结果

注：A示两下肺背段磨玻璃样高密度影，以左下肺背段为显著；B示左下肺磨玻璃样高密度影，密度不均匀；C示左上肺外带磨玻璃样稍高密度影；D示两下肺基底段斑片状、磨玻璃样高密度影，密度不均匀；E示右下肺磨玻璃样稍高密度影；F示两下肺磨玻璃样稍高密度影。

Figure 1. Results of chest CT scan

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表 1 11例COVID-19未成年患者的临床表现和相关实验室结果

Table 1. Clinical manifestations and related laboratory examinations of 11 juvenile cases of COVID-19

项目	数值
年龄[M(P₂₅, P₇₅), 年]	10.54(7.50, 13.00)
发热天数[M(P₂₅, P₇₅), d]	5.36(4.81, 10.23)
体温[M(P₂₅, P₇₅), ℃]	37.6(36.4, 38.6)
从入院到确诊的时间[M(P₂₅, P₇₅), d]	2.23(1.51, 3.46)
咳嗽天数[M(P₂₅, P₇₅), d]	5.33(4.68, 11.89)
咳嗽[例(%)]	2(18.2)
咽喉痛[例(%)]	2(18.2)
鼻塞伴流涕[例(%)]	4(36.4)
肌肉疼痛[例(%)]	1(9.1)
腹泻[例(%)]	1(9.1)
上呼吸道症状[例(%)]	8(72.7)
头痛[例(%)]	3(27.2)
家庭成员感染[例(%)]	11(100.0)
与武汉的联系[例(%)]	3(27.2)
C反应蛋白(mg/L)	11.80 (6.20, 13.05)
血红蛋白(mg/L)	127.00(121.00, 132.00)
血细胞比容(%)	42.20(36.00，46.05)
血小板(×10⁹/L)	281.00(222.50, 304.50)
白细胞(×10⁹/L)	5.84(4.96, 6.35)
淋巴细胞(%)	31.60(27.20, 35.10)
淋巴细胞计数(×10⁹/L)	0.77(0.73, 2.40)
中性粒细胞百分比(%)	57.90(42.90，58.95)
中性粒细胞计数(×10⁹/L)	2.81(2.05, 3.12)
嗜酸性粒细胞比值(%)	2.10(1.60，2.35)
嗜酸性粒细胞计数(×10⁹/L)	0.10(0.08, 0.14)
嗜碱性粒细胞比值(%)	0.30(0.20，0.35)
嗜碱性粒细胞计数(×10⁹/L)	0.01(0.01, 0.02)
单核细胞百分比(%)	6.90(5.80，7.60)
单核细胞计数(×10⁹/L)	0.37(0.31, 0.41)
降钙素原(%)	0.24(0.19，0.30)
谷丙转氨酶ALT(U/L)	12.00(9.90, 39.36)
谷草转氨酶AST(U/L)	25.20(16.8, 37.58)

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