细胞衍生物在心脏损伤修复方面的研究进展及应用展望

李德民; 路永政; 秦臻; 徐彦彦; 张力; 张金盈; 唐俊楠

doi:10.16766/j.cnki.issn.1674-4152.002379

细胞衍生物在心脏损伤修复方面的研究进展及应用展望

doi: 10.16766/j.cnki.issn.1674-4152.002379

李德民¹,
路永政¹,
秦臻¹,
徐彦彦¹,
张力¹,
张金盈^{1, 2},
唐俊楠^{1, 2, ,}

1.
郑州大学第一附属医院心血管内科，河南郑州 450052
2.
河南省心脏损伤修复重点实验室，河南郑州 450052

基金项目:

国家自然科学基金青年基金项目 81800267

河南省自然科学基金-优秀青年基金项目 202300410362

详细信息

通讯作者:
唐俊楠，E-mail：fcctangjn@zzu.edu.cn

中图分类号: R542.22 R541
计量
- 文章访问数: 198
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- PDF下载量: 3
- 被引次数: 0
出版历程
- 收稿日期: 2021-06-18
- 网络出版日期: 2022-08-13

Cell derivatives in heart injury repair progress and application prospects

1.
Department of Cardiology, the First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, China

摘要

摘要: 急性心肌梗死(AMI)仍然是导致冠心病患者死亡的首要原因。需要针对AMI后心脏的损伤修复研究出新的治疗策略，最新的研究表明细胞衍生物在心脏损伤修复方面展现出巨大的潜力，是当今医学研究的热点。细胞衍生物包括细胞外囊泡(EVs)、非编码RNA、生长因子等。文章结合最新的研究进展，展现了心肌细胞、内皮细胞、免疫细胞衍生的EVs在AMI后的变化以及作用；总结了临床前研究以及临床研究中微小核糖核酸、长链非编码核糖核酸、环状核糖核酸在AMI后的变化以及作用；重点介绍了血管内皮生长因子以及成纤维细胞生长因子在AMI后的变化及作用；最后从临床应用角度总结了EVs、非编码RNA、生长因子作为诊断和预测临床疾病进展的生物标志物相关的研究，以及利用这些细胞衍生物作为AMI治疗手段的研究。总之，细胞衍生物在心脏损伤修复方面有非常大的潜力，值得深入研究。
- 细胞衍生物 /
- 急性心肌梗死 /
- 心脏损伤修复 /
- 临床应用
Abstract: Acute myocardial infarction (AMI) is still the leading cause of death in patients with coronary heart disease. New treatment strategies for repairing the damaged heart after AMI need to be developed. The latest research shows that cell derivatives exhibit great potential in the repair of heart damage, which is a hot spot in current medical research. Cell derivatives include extracellular vehicles (EVs), non-coding RNA, and growth factors. Combined with the latest research progress, this review shows the changes and functions of EVs derived from cardiomyocytes, endothelial cells and immune cells after AMI. The changes and effects of microribonucleic acid, long non-coding ribonucleic acid and circular ribonucleic acid in preclinical and clinical research after AMI are summarised. The focus is on the changes and effects of vascular endothelial growth factor and fibroblast growth factor after AMI. Finally, from the perspective of clinical application, the research on EVs, non-coding RNA, growth factors as biomarkers for the diagnosis and prediction of clinical disease progression, and the use of these cell derivatives as treatment methods for AMI are summarised. In short, cell derivatives have great potential in the repair of heart damage and are worthy of in-depth study.
- Cell derivatives /
- Acute myocardial infarction /
- Heart damage repair /
- Clinical application

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