Efficacy of the treatment with ultrasonic debridement combined with RhEGF in patients with perianal abscess infection
-
摘要:
目的 探讨超声清创联合重组人表皮生长因子(RhEGF)治疗肛周脓肿感染的疗效。 方法 选取2019年2月—2021年2月衢州市中医医院收治的112例肛周脓肿感染患者,按照治疗方法的不同将其分为超声组(37例)、RhEGF组(37例)、观察组(38例)。3组患者均常规给予抗菌药物,超声组给予超声清创治疗,RhEGF组给予RhEGF治疗,观察组给予超声清创联合RhEGF治疗。比较3组患者临床指标水平、疼痛程度、创面细菌清除率、微循环指标水平。 结果 观察组创面愈合时间[(15.49±2.18)d]、住院时间[(15.53±2.06)d]短于超声组[(18.06±2.01)、(18.52±1.73)d]、RhEGF组[(17.84±1.93)、(17.98±1.85)d, F=18.291、26.852,均P < 0.001];3组患者治疗后1 d视觉模拟量表评分低于治疗前(均P < 0.05),且观察组低于超声组、RhEGF组(F=30.093,P < 0.001);3组患者治疗后3 d创面细菌清除率高于治疗后1 d(均P < 0.05),且观察组治疗后1、3 d创面细菌清除率高于超声组、RhEGF组(F=22.183、31.650,均P < 0.001);3组患者治疗后1 d创面血流量、经皮氧分压及血清表皮生长因子水平高于治疗前(均P < 0.05),且观察组高于超声组、RhEGF组(F=4.406、20.210、51.552,P值为0.015、 < 0.001、 < 0.001)。 结论 超声清创联合RhEGF治疗肛周脓肿感染疗效显著,有助于患者早日康复。 Abstract:Objective To explore the efficacy of the treatment with ultrasonic debridement combined with recombinant human epidermal growth factor (RhEGF) in perianal abscess infection. Methods A total of 112 patients with perianal abscess infection admitted to Quzhou Hospital of Traditional Chinese Medicine, Zhejiang Province from Feb. 2019 to Feb. 2021 were selected and divided into ultrasound group (n=37), RhEGF group (n=37) and observation group (n=38) according to different treatment methods. Three group were given conventional antibiotics, the ultrasound group was treated with ultrasonic debridement, the RhEGF group was treated with RhEGF, and the observation group was treated with ultrasonic debridement combined with RhEGF. The clinical index level, pain degree, wound bacterial clearance rate and microcirculation index level were compared of three groups. Results The wound healing time and hospital stay in the observation group [(15.49±2.18) d, (15.53±2.06) d] were lower than those in the ultrasound group [(18.06±2.01) d, (18.52±1.73) d] and RhEGF group [(17.84±1.93) d, (17.98±1.85) d, F=18.291, 26.852, all P < 0.001]. The visual analogue scale score of 3 groups after treatment 1 d was lower than that before treatment (all P < 0.05), and the observation group was lower than that in the ultrasound group and RhEGF group (F=30.093, P < 0.001). The wound bacterial clearance rate of 3 groups after treatment 3 d was higher than that in after treatment 1 d (all P < 0.05), and the wound bacterial clearance rate after treatment 1 d and 3 d in the observation group were higher than those in the ultrasound group and RhEGF group (F=22.183, 31.650, all P < 0.001). The wound blood flow, percutaneous partial oxygen pressure and the level of serum epidermal growth factor of 3 groups after treatment 1 d were higher than those before treatment (all P < 0.05), and the observation group were higher than those in the ultrasound group and RhEGF group (F=4.406, 20.210, 51.552, the P value were 0.015, < 0.001, < 0.001, respectively). Conclusion Ultrasonic debridement combined with RhEGF is effective in the treatment of perianal abscess infection, which is helpful to the early recovery of patients. -
表 1 3组肛周脓肿感染患者一般资料比较
Table 1. Comparison of general data of three groups of patients with perianal abscess infection
组别 例数 性别(例) 年龄(x±s, 岁) 病程(x±s, d) 脓肿面积(x±s, cm2) 脓肿部位(例) 男性 女性 高位肌间 直肠后间隙 骨盆直肠间隙 超声组 37 21 16 44.72±9.16 8.01±1.37 10.19±1.75 8 20 9 RhEGF组 37 23 14 43.15±8.57 8.22±1.66 10.53±1.84 10 19 8 观察组 38 25 13 46.93±7.22 7.85±1.14 10.41±1.62 9 22 7 统计量 0.654a 1.944b 0.654b 0.364b 0.683a P值 0.721 0.148 0.529 0.696 0.953 注:a为χ2值,b为F值。 表 2 3组肛周脓肿感染患者临床指标比较(x±s, d)
Table 2. Comparison of clinical indicators in three groups of patients with perianal abscess infection (x±s, d)
组别 例数 创面愈合时间 住院时间 超声组 37 18.06±2.01a 18.52±1.73a RhEGF组 37 17.84±1.93a 17.98±1.85a 观察组 38 15.49±2.18 15.53±2.06 F值 18.291 26.852 P值 < 0.001 < 0.001 注:与观察组比较,aP < 0.05。 表 3 3组肛周脓肿感染患者VAS评分比较(x±s, 分)
Table 3. Comparison of VAS scores in three groups of patients with perianal abscess infection (x±s, d)
组别 例数 治疗前 治疗后1 d 超声组 37 6.34±1.72 4.05±0.77ab RhEGF组 37 6.19±1.36 3.86±0.69ab 观察组 38 6.47±1.08 2.97±0.43b F值 0.371 30.093 P值 0.691 < 0.001 注:与观察组比较,aP < 0.05;与同组治疗前比较,bP < 0.05。 表 4 3组肛周脓肿感染患者创面细菌清除率比较(x±s, %)
Table 4. Comparison of bacterial clearance rate of wounds in three groups of patients with perianal abscess infection (x±s, %)
组别 例数 治疗后1 d 治疗后3 d 超声组 37 53.72±6.26a 65.32±7.47ab RhEGF组 37 54.37±6.63a 67.15±8.39ab 观察组 38 62.84±6.97 78.43±7.34b F值 22.183 31.650 P值 < 0.001 < 0.001 注:与观察组比较,aP < 0.05;与同组治疗后1 d比较,bP < 0.05。 表 5 3组肛周脓肿感染患者微循环指标比较(x±s)
Table 5. Comparison of microcirculation indexes in three groups of patients with perianal abscess infection (x±s)
组别 例数 创面血流量(PU) 经皮氧分压(mm Hg) 血清EGF(μg/L) 治疗前 治疗后1 d 治疗前 治疗后1 d 治疗前 治疗后1 d 超声组 37 0.69±0.22 0.76±0.21ab 27.84±3.20 31.29±3.47ab 0.19±0.04 0.49±0.05ab RhEGF组 37 0.72±0.27 0.82±0.28ab 28.16±3.88 32.16±3.35ab 0.21±0.06 0.51±0.06ab 观察组 38 0.74±0.23 0.93±0.26b 28.23±3.16 36.23±3.94b 0.20±0.05 0.63±0.08b F值 0.409 4.406 0.137 20.210 1.442 51.552 P值 0.888 0.015 0.872 < 0.001 0.241 < 0.001 注:与观察组比较,aP < 0.05;与同组治疗前比较,bP < 0.05。1 mm Hg=0.133 kPa。 -
[1] ZHONG Z, HUANG H, HAN Y, et al. Efficacy of continuous intravenous pumping of insulin for patients with diabetes complicated with perianal abscess and the effect on inflammatory cytokines[J]. Exp Ther Med, 2019, 18(3): 1539-1544. [2] 许跃文. 肛周脓肿三间隙引流术的临床应用效果[J]. 现代医药卫生, 2018, 34(16): 2550-2552. doi: 10.3969/j.issn.1009-5519.2018.16.039XU Y W. Clinical application effect of three-space drainage in perianal abscess[J]. Journal of Modern Medicine & Health, 2018, 34(16): 2550-2552. doi: 10.3969/j.issn.1009-5519.2018.16.039 [3] 李乾元, 周秀扣, 方征宇. 自拟中药汤剂对早期低位肛周脓肿患者临床症状以及炎症反应的改善作用分析[J]. 中华全科医学, 2019, 17(7): 1191-1193, 1217. doi: 10.16766/j.cnki.issn.1674-4152.000898LI Q Y, ZHOU X K, FANG Z Y. Efficacy of self-made traditional Chinese medicine decoction on the clinical symptoms and inflammatory reaction in patients with low level perianal abscess in an early stage[J]. Chinese Journal of General Practice, 2019, 17(7): 1191-1193, 1217. doi: 10.16766/j.cnki.issn.1674-4152.000898 [4] 黄方军, 刘阳, 潘敏, 等. 一次性切开根治术与传统切开引流术治疗肛周脓肿的疗效比较[J]. 安徽医学, 2020, 41(4): 470-472. doi: 10.3969/j.issn.1000-0399.2020.04.032HUANG F J, LIU Y, PAN M, et al. Comparison of curative effect of one-time open radical resection and traditional open drainage in the treatment of perianal abscess[J]. Anhui Medical Journal, 2020, 41(4): 470-472. doi: 10.3969/j.issn.1000-0399.2020.04.032 [5] 贾国璞, 刘丽飞, 刘晓丽, 等. 肛周脓肿术后应用超声清创对缓解创面疼痛及细菌清除的疗效观察[J]. 中国临床医生杂志, 2019, 47(9): 1078-1080. doi: 10.3969/j.issn.2095-8552.2019.09.024JIA G P, LIU LIFEI, LIU XIAOLI, et al. Effect of ultrasonic debridement on wound pain relief and bacterial removal after perianal abscess surgery[J]. Chinese Journal for Clinicians, 2019, 47(9): 1078-1080. doi: 10.3969/j.issn.2095-8552.2019.09.024 [6] 邹世镇, 王炜, 陈德伦. 肛周脓肿术后创面愈加速合方法的研究进展[J]. 结直肠肛门外科, 2018, 24(5): 523-527. https://www.cnki.com.cn/Article/CJFDTOTAL-DCGM201805025.htmZOU S Z, WANG W, CHEN D L. Research progress of accelerated healing method of perianal abscess after surgery[J]. Journal of Colorectal & Anal Surgery, 2018, 24(5): 523-527. https://www.cnki.com.cn/Article/CJFDTOTAL-DCGM201805025.htm [7] CACUA SANCHEZ M T, GIRALDO L F, DÍAZ J A. Efficacy of human recombinant epidermal growth factors vs conventional therapy for the treatment of chronic venous ulcers: A retrospective case series[J]. Wounds, 2021, 33(2): 41-49. [8] 安阿玥. 肛肠病学[M]. 北京: 人民卫生出版社, 2015: 555-558.AN A Y. Anal enterology[M]. Beijing: People ' s Medical Publishing House, 2015: 555-558. [9] 王德英. 龙血竭散促进肛周脓肿术后切口愈合的临床疗效研究[J]. 现代医药卫生, 2021, 37(1): 103-105. doi: 10.3969/j.issn.1009-5519.2021.01.029WANG D Y. Clinical efficacy of longxuejie powder in promoting wound healing after perianal abscess surgery[J]. Journal of Modern Medicine & Health, 2021, 37(1): 103-105. doi: 10.3969/j.issn.1009-5519.2021.01.029 [10] 陆坚, 徐照秀, 吴帅军, 等. 近3年肛周脓肿及肛瘘感染病原菌分布及耐药性分析[J]. 国际检验医学杂志, 2015, 36(21): 3189-3191. doi: 10.3969/j.issn.1673-4130.2015.21.052LU J, XU Z X, WU S J, et al. Distribution and drug resistance of pathogens in perianal abscess and anal fistula infection in recent 3 years[J]. International Journal of Laboratory Medicine, 2015, 36(21): 3189-3191. doi: 10.3969/j.issn.1673-4130.2015.21.052 [11] 蒋宇. 肛周脓肿患者病情严重程度与纤维蛋白原、D-二聚体水平相关性分析[J]. 中国临床医学, 2020, 27(5): 841-843. https://www.cnki.com.cn/Article/CJFDTOTAL-LCYX202005026.htmJIANG Y. Correlation analysis between the severity of perianal abscess and levels of fibrinogen and D-dimer[J]. Chinese Journal of Clinical Medicine, 2020, 27(5): 841-843. https://www.cnki.com.cn/Article/CJFDTOTAL-LCYX202005026.htm [12] 方瑞忠, 罗明雷, 马传玉. 高压氧联合复方黄柏液治疗肛周脓肿术后创面愈合的临床研究[J]. 中华航海医学与高气压医学杂志, 2018, 25(4): 254-256, 266. doi: 10.3760/cma.j.issn.1009-6906.2018.04.010FANG R Z, LUO M L, MA C Y. Clinical research on the efficacy of hyperbaric oxygen combined with Fufanghuangbai liquid on wound healing after perianal abscess surgery[J]. Chinese Journal of Nautical Medicine and Hyperbaric Medicine, 2018, 25(4): 254-256, 266. doi: 10.3760/cma.j.issn.1009-6906.2018.04.010 [13] 贾国璞, 刘晓丽, 陈建华. 超声清创联合生物反馈治疗对肛周脓肿术后创面愈合及括约肌功能恢复的临床观察[J]. 河北医学, 2018, 24(8): 1346-1351. doi: 10.3969/j.issn.1006-6233.2018.08.031JIA G P, LIU X L, CHEN J H. Clinical observation of ultrasonic debridement combined with biofeedback therapy on postoperative wound healing and recovery of sphincter function in perianal abscess[J]. Hebei Medicine, 2018, 24(8): 1346-1351. doi: 10.3969/j.issn.1006-6233.2018.08.031 [14] 李文波, 刁春鹏, 吕兴波, 等. 高压氧联合超声清创术对糖尿病足溃疡创面细菌清除及微循环的影响[J]. 中华航海医学与高气压医学杂志, 2021, 28(1): 64-68.LI W B, DIAO C P, LV X B, et al. Effect of hyperbaric oxygen combined with ultrasonic debridement on bacterial clearance and microcirculation of diabetic foot ulcer wound[J]. Chinese Journal of Nautical Medicine and Hyperbaric Medicine, 2021, 28(1): 64-68. [15] 李志斌, 宋立峰, 郭兴芳, 等. 重组人表皮生长因子凝胶对老年混合痔患者术后创面恢复的影响研究[J]. 结直肠肛门外科, 2018, 24(1): 56-60. https://www.cnki.com.cn/Article/CJFDTOTAL-DCGM201801020.htmLI Z B, SONG L F, GUO X F, et al. Effect of recombinant human epidermal growth factor gel on the recovery of the wound in older patients with mixed hemorrhoids after operation[J]. Journal of Colorectal & Anal Surgery, 2018, 24(1): 56-60. https://www.cnki.com.cn/Article/CJFDTOTAL-DCGM201801020.htm [16] XIE X L, GUAN W J, TANG X Y, et al. A combination of ultrasonic debridement and Shenghong wet dressing in patients with chronic ulcers of the lower limbs[J]. J Int Med Res, 2019, 47(10): 4656-4663. doi: 10.1177/0300060519858033 [17] 何永芬, 梁洪敏. 慢性伤口应用超声波清创机清创的效果[J]. 中国临床研究, 2020, 33(5): 719-720. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGCK202005039.htmHE Y F, LIANG H M. Effects of ultrasonic debridement machine on chronic wounds[J]. Chinese Journal of Clinical Research, 2020, 33(5): 719-720. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGCK202005039.htm [18] TAN L, HOU Z, GAO Y. Efficacy of combined treatment with vacuum sealing drainage and recombinant human epidermal growth factor for refractory wounds in the extremities and its effect on serum levels of IL-6, TNF-α and IL-2[J]. Exp Ther Med, 2018, 15(1): 288-294. [19] 宋茹, 张丽娟, 张丝丝. 硼酸软膏联合重组人表皮生长因子凝胶治疗压疮的临床研究[J]. 现代药物与临床, 2019, 34(11): 3363-3366. https://www.cnki.com.cn/Article/CJFDTOTAL-GWZW201911036.htmSONG R, ZHANG L J, ZHANG S S. Clinical study on boric acid ointment combined with recombinant human epidermal growth factor gel in treatment of pressure ulcers[J]. Drugs & Clinic, 2019, 34(11): 3363-3366. https://www.cnki.com.cn/Article/CJFDTOTAL-GWZW201911036.htm [20] 邓旭辉, 曾元临, 江澜, 等. 富血小板血浆在创面修复临床应用中的研究进展[J]. 中国医药, 2021, 16(11): 1757-1760. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYG202111037.htmDENG X H, ZENG Y L, JIANG L, et al. Research progress of platelet-rich plasma in clinical application of wound repair[J]. China Medicine, 2021, 16(11): 1757-1760. https://www.cnki.com.cn/Article/CJFDTOTAL-ZGYG202111037.htm [21] 艾力麦尔旦·艾尼瓦尔, 木合塔尔·霍加. 生长因子诱导牙髓干细胞成骨向分化研究进展[J]. 中华实用诊断与治疗杂志, 2019, 33(2): 205-208. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZD201902030.htmELIMERDAN E, MUHETHAR H. Progress of growth factor inducing osteogenic differentiation of dental pulp stem cells[J]. Journal of Chinese Practical Diagnosis and Therapy, 2019, 33(2): 205-208. https://www.cnki.com.cn/Article/CJFDTOTAL-HNZD201902030.htm [22] 贾国璞, 刘丽飞, 刘晓丽. 超声清创对肛周脓肿术后创面生长因子及微循环影响[J]. 临床军医杂志, 2018, 46(9): 1079-1080, 1082. https://www.cnki.com.cn/Article/CJFDTOTAL-JYGZ201809034.htmJIA G P, LIU L F, LIU X L. Effects of ultrasonic debridement on wound growth factor and microcirculation after perianal abscess surgery[J]. Clinical Journal of Medical Officers2018, 46(9): 1079-1080, 1082. https://www.cnki.com.cn/Article/CJFDTOTAL-JYGZ201809034.htm [23] 高桂云, 宋维民, 米园园, 等. 肛周脓肿患者超声清创效果及对肛门括约肌功能的影响[J]. 山东医药, 2021, 61(8): 79-81. doi: 10.3969/j.issn.1002-266X.2021.08.020GAO G Y, SONG W M, MI Y Y, et al. Effects of ultrasonic debridement on anal sphincter function in patients with perianal abscess[J]. Shandong Medical Journal, 2021, 61(8): 79-81. doi: 10.3969/j.issn.1002-266X.2021.08.020 [24] 韩静, 金飞锋, 王海燕. 前列地尔联合重组人表皮生长因子对老年糖尿病足溃疡创面微环境和炎症反应的影响[J]. 中国老年学杂志, 2020, 40(20): 4295-4297. doi: 10.3969/j.issn.1005-9202.2020.20.012HAN J, JIN F F, WANG H Y. Effects of alprostadil combined with recombinant human epidermal growth factor on wound microenvironment and inflammatory response in elderly diabetic foot ulcers[J]. Chinese Journal of Gerontology, 2020, 40(20): 4295-4297. doi: 10.3969/j.issn.1005-9202.2020.20.012
计量
- 文章访问数: 124
- HTML全文浏览量: 65
- PDF下载量: 2
- 被引次数: 0