颈动脉粥样硬化斑块超声联合血脂指标对心血管疾病的预测价值评估

管晶晶; 时鹏; 李保伍; 刘贝贝; 隋洋; 周平辉; 陈宇

doi:10.16766/j.cnki.issn.1674-4152.002601

颈动脉粥样硬化斑块超声联合血脂指标对心血管疾病的预测价值评估

doi: 10.16766/j.cnki.issn.1674-4152.002601

管晶晶¹,
时鹏²,
李保伍¹,
刘贝贝¹,
隋洋³,
周平辉⁴,
陈宇^5, ,

1.
蚌埠医学院第一附属医院健康管理中心, 安徽蚌埠 233004
2.
蚌埠医学院第一附属医院神经内科
3.
蚌埠医学院第一附属医院彩超室
4.
蚌埠医学院第一附属医院骨科
5.
蚌埠医学院第一附属医院整形外科

基金项目:

国家自然科学基金青年基金项目 31700854

详细信息

通讯作者:
陈宇, E-mail: chenyu9493@hotmail.com

中图分类号: R54 R445.1
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- 文章访问数: 142
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- PDF下载量: 2
- 被引次数: 0
出版历程
- 收稿日期: 2022-01-25
- 网络出版日期: 2022-09-26

Value evaluation of carotid atherosclerotic plaque ultrasound combined with blood lipid index in predicting cardiovascular disease

1.
Health Management Center, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

摘要

摘要: 目的探讨颈动脉粥样硬化斑块超声联合血脂指标对心血管疾病的预测价值评估。方法选取2019年1月-2021年12月在蚌埠医学院第一附属医院确诊为颈动脉斑块的59例体检者作为观察组, 选取同期59名健康体检者作为对照组, 所有受试者均行颈动脉超声检查和血脂水平测定。结果观察组的颈动脉内中膜厚度(IMT)值为(1.58±0.34) mm, 其与对照组IMT值[(0.76±0.12) mm]相比明显更高, 差异有统计学意义(P < 0.05);观察组的LDL-C值和HDL-C值分别为(3.09±1.01) mmol/L和(1.18±0.37) mmol/L, 其与对照组相对应的LDL-C值[(2.67±0.68) mmol/L和HDL-C值(1.33±0.32) mmol/L]相比, 前者显著升高而后者显著降低, 且差异有统计学意义(均P < 0.05);观察组的TC值[(4.94±1.18) mmol/L]和TG值[(1.85±0.67) mmol/L]与对照组[(4.69±0.76) mmol/L、(1.71±0.92) mmol/L]相比虽有一定的升高, 但差异均无统计学意义(均P>0.05)。结论心脑血管疾病与血脂异常以及动脉粥样硬化斑块的形成发展具有密切相关性, 高水平的TC、TG和LDL-C导致动脉IMT的增厚继而形成动脉粥样硬化斑块。因此, 对于高脂血症的患者应行颈动脉彩超检查以判断动脉粥样硬化斑块情况, 为早期调控血脂以积极预测相关并发症提供一定的诊断价值。
- 颈动脉超声 /
- 血脂 /
- 动脉粥样硬化斑块
Abstract: Objective To conduct the value evaluation of carotid atherosclerotic plaque ultrasound combined with blood lipid index in predicting cardiovascular disease. Methods Fifty-nine physical examination patients diagnosed with carotid plaque in The First Affiliated Hospital of Bengbu Medical College from January 2019 to December 2021 were selected as the observation group, and 59 healthy physical examination patients attending our hospital were selected as the control group during the same period.All subjects underwent carotid ultrasound examination and lipid level measurement. Results The IMT value of the observation group was (1.58±0.34) mm, which was significantly higher than that of the control group[(0.76±0.12) mm], and the difference was statistically significant (P < 0.05).The LDL-C value and HDL-C value of the observation group were (3.09±1.01) mmol/L and (1.18±0.37) mmol/L respectively.Compared with the LDL-C value[(2.67±0.68) mmol/L]and HDL-C value[(1.33±0.32) mmol/L]of the control group, the former was significantly higher and the latter was significantly lower, and the difference was statistically significant (all P < 0.05).However, the TC value of the observation group was (4.94±1.18) mmol/L and TG value was (1.85±0.67) mmol/L, which were higher than those of the control group[TC value was (4.69±0.76) mmol/L and TG value was (1.71±0.92) mmol/L].Although there was a certain increase, the difference was not statistically significant (all P>0.05). Conclusion Cardiovascular diseases are closely related to dyslipidemia and the development of atherosclerotic plaque formation.High levels of TC, TG and LDL-C lead to the thickening of arterial IMT and the development of atherosclerotic plaque.Therefore, carotid ultrasound should be performed in patients with hyperlipidemia to determine the condition of atherosclerotic plaque, which can provide some diagnostic value for the early regulation of blood lipids and active predicting of related complications.
- Carotid ultrasound /
- Lipid /
- Atherosclerotic plaque

HTML全文

图 1 2组受试者的颈动脉超声成像

注：A和B分别为正常颈动脉和颈动脉斑块的二维超声图；C为颈动脉斑块彩色多普勒。

Figure 1. Carotid ultrasound imaging of subjects in two groups

下载: 全尺寸图片幻灯片

表 1 2组受试者的一般资料比较

Table 1. The general data of the two groups were compared

组别	例数	年龄 (x±s，岁)	性别[例(%)]		职业[例(%)]			既往史 [例(%)]
组别	例数	年龄 (x±s，岁)	男性	女性	工人	农民	其他	既往史 [例(%)]
观察组	59	59.4±11.3	45(76.27)	14(23.73)	14(23.73)	23(38.98)	22(37.29)	28(47.46)
对照组	59	54.6±8.6	43(72.88)	16(27.12)	15(25.42)	21(35.60)	23(38.98)	30(50.85)
统计量		0.679^a	0.179^b		1.022^b			0.136^b
P值		0.589	0.672		0.560			0.714
注：^a为t值，^b为χ²值。

下载: 导出CSV

表 2 2组受试者的血脂水平比较(x ±s，mmol/L)

Table 2. Comparison of blood lipid levels between the two groups(x ±s, mmol/L)

组别	例数	TC	TG	LDL-C	HDL-C
观察组	59	4.94±1.18	1.85±0.67	3.09±1.01	1.18±0.37
对照组	59	4.69±0.76	1.71±0.92	2.67±0.68	1.33±0.32
t值		1.800	0.966	6.569	5.694
P值		0.182	0.328	0.020	0.012

下载: 导出CSV

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