基于菌-肠-脑轴的肠肽与焦虑抑郁关系的研究进展

刘莉

doi:10.16766/j.cnki.issn.1674-4152.002604

基于菌-肠-脑轴的肠肽与焦虑抑郁关系的研究进展

doi: 10.16766/j.cnki.issn.1674-4152.002604

刘莉

赣州市人民医院消化内科, 江西赣州 341000

详细信息

作者简介:
刘莉：E-mail：d1152932074@163

中图分类号: R749.4 R574
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出版历程
- 收稿日期: 2021-09-12
- 网络出版日期: 2022-09-26

Research progress of intestinal peptides and the occurrence of anxiety and depression on the basis of the microbiota-gut-brain axis

LIU Li

Department of Gastroenterology, Ganzhou People ' s Hospital, Ganzhou, Jiangxi 341000, China

摘要

摘要: 焦虑抑郁是由于不良情绪引起机体出现应激反应而导致的躯体性障碍，是生物、心理和社会因素共同作用导致的心理、生理症状并存的疾病，是当代社会最常见的心理疾病。该病不仅降低个人的生活质量, 还给家庭和社会带来巨大的经济负担。近年来随着高通量测序、序列识别技术及肠道宏基因组学的成熟，肠道微生物的作用被广泛认识和重视。肠道与中枢神经系统间存在着复杂的双向交流，由内分泌、免疫、肠道神经系统等多个系统精心协调完成。因此，肠道又被称为是人体的“第二大脑”。既往研究表明，肠道微生物可能作为微炎性反应状态的启动者，其介导的肠道稳态失衡，进而导致“菌-肠-脑”功能紊乱，在焦虑抑郁的发病过程中起着重要的作用，但具体致病机制目前尚不明确。作为人体最大的内分泌器官，肠道可以分泌数十种不同的信号分子，多以肽类为主。而分泌到体循环中的肠肽可与免疫细胞和迷走神经末梢上的同源受体结合，从而实现间接的肠脑沟通。因此，本文就肠肽作为菌-肠-脑轴的信号分子对焦虑抑郁的影响进行综述，以期为焦虑抑郁的临床诊治提供一定的参考。通过调节肠道微生物来改变抑郁焦虑等心理疾病已成为神经科学和心理学的热点, 维护良好的肠道菌群可能是未来焦虑抑郁预防和治疗的重要方向。
- 肠肽 /
- 焦虑 /
- 抑郁 /
- 菌-肠-脑轴
Abstract: Anxiety and depression are physical disorders caused by stress response or bad emotions. They are diseases in which psychological and physical symptoms coexist caused by the combined action of biological, psychological and social factors. They are the most common psychological diseases in contemporary society. They not only reduce the quality of life of an individual, but also bring huge economic burden to the family and society. In recent years, with the maturity of high-throughput sequencing, sequence recognition technology and intestinal metagenomics, the role of intestinal microbes has been widely recognised and valued. There is a complex two-way communication between the intestine and the central nervous system, which is finely orchestrated by multiple systems such as endocrine, immune and enteric nervous systems. Therefore, the intestine is also known as the "second brain" of the human body. Previous studies have shown that intestinal microbes may act as initiators of the micro-inflammatory response state, which mediates the imbalance of intestinal homeostasis, leading to "bacteria-gut-brain" dysfunction, which plays an important role in the onset of anxiety and depression. However, the specific pathogenic mechanism is currently unclear. As the largest endocrine organ of the human body, the intestine can secrete dozens of different signal molecules, mostly peptides. Intestinal peptides secreted into the systemic circulation can bind to immune cells and homologous receptors on the vagus nerve endings, thereby realising indirect intestinal-brain communication. Therefore, this article summarises the influence of intestinal peptides as signal molecules of the bacteria-gut-brain axis on anxiety and depression, in order to provide a certain basis and reference for the clinical diagnosis and treatment of anxiety and depression. Changing psychological diseases such as depression and anxiety by regulating intestinal microbes has become a hot topic in neuroscience and psychology. Maintaining a good intestinal flora may be an important direction for the prevention and treatment of depression and anxiety in the future.
- Intestinal peptides /
- Anxiety /
- Depression /
- Microbiota-gut-brain axis

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