脊柱截骨术对家兔脊髓功能的影响

朱仲廉; 赵志; 王照东; 高许斌; 王旭义; 官建中

doi:10.16766/j.cnki.issn.1674-4152.002630

脊柱截骨术对家兔脊髓功能的影响

doi: 10.16766/j.cnki.issn.1674-4152.002630

朱仲廉^{1, 2},
赵志^{1, 2},
王照东^{1, 2},
高许斌^{1, 2},
王旭义^{1, 2},
官建中^{1, 2, ,}

1.
蚌埠医学院第一附属医院骨科，安徽蚌埠 233004
2.
组织移植安徽省重点实验室，安徽蚌埠 233004

基金项目:

安徽省教育厅重点项目 SK2018A1077

蚌埠医学院自然科学重点项目 BYKY2019039ZD

蚌埠医学院自然科学基金面上项目 BYKY1776

详细信息

通讯作者:
官建中, E-mail: jzguan2002@163.com

中图分类号: R687.31
计量
- 文章访问数: 114
- HTML全文浏览量: 71
- PDF下载量: 4
- 被引次数: 0
出版历程
- 收稿日期: 2022-02-09
- 网络出版日期: 2022-11-29

Effects of vertebral osteotomy on spinal-cord function in rabbits

ZHU Zhong-lian^{1, 2},
ZHAO Zhi^{1, 2},
WANG Zhao-dong^{1, 2},
GAO Xu-bin^{1, 2},
WANG Xu-yi^{1, 2},
GUAN Jian-zhong^{1, 2
, ,}

1.
Department of Orthopedics, the First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, China

摘要

摘要: 目的研究脊椎截骨术对脊髓功能的影响，为脊椎截骨术的临床应用提供理论依据。方法将40只家兔以随机数字表法分为对照组、低截骨组(截骨后压缩25%)、中截骨组(截骨后压缩50%)、高截骨组(截骨后压缩100%)，每组10只，给予相应的手术处理。测定硬膜皱缩、运动功能(Reuter评分)、脊髓血流量等指标。结果中截骨组、高截骨组的硬膜囊横径、迂曲角为(5.74±0.29)mm、(14.46±0.77)°和(7.65±0.36)mm、(85.62±2.95)°，显著大于低截骨组[(4.85±0.32)mm、0°]和对照组[(4.39±0.11)mm、0°], 均P＜0.05。中截骨组、高截骨组的脊髓血流量为(27.66±0.85)μL/100 μm³、(10.53±0.24)μL/100 μm³，显著低于低截骨组[(34.28±0.94)μL/100 μm³]和对照组[(33.81±1.06) μL/100 μm³]，均P＜0.05。低截骨组、中截骨组、高截骨组的Reuters评分为(2.38±0.34)分、(7.25±0.42)分、(9.56±0.73)分，显著大于对照组的(1.39±0.25)分，均P＜0.05。结论脊椎截骨术具有较好的临床效果，较短的脊柱缩短对机体脊髓功能的影响小，临床实践中应注意把握安全截骨的临界值。
- 脊柱短缩术 /
- 脊髓功能 /
- 脊髓血流量
Abstract: Objective To explore the effect of vertebral osteotomy on the function of the spinal cord and to provide a theoretical basis for the clinical application of vertebral osteotomy. Methods By random-number table method, 40 rabbits were randomly divided into a control group, a low osteotomy group (compression 25% after osteotomy), a middle osteotomy group (compression 50% after osteotomy), and a high osteotomy group (compression 100% after osteotomy), with 10 animals each. They were given corresponding surgical treatment. Dural shrinkage, motor function (Reuter score), spinal-cord blood flow, and other indicators were determined. Results The dural sac transverse diameter and spinal cord of the middle and high osteotomy groups were (5.74±0.29) mm, (14.46±0.77)° and (7.65±0.36) mm, (85.62±2.95)°, which were higher than those of the low osteotomy[(4.85±0.32) mm, 0°] and control group [(4.39±0.11) mm, 0°], all P < 0.05. The blood flow of the middle and high osteotomy groups were (27.66±0.85) μL/100 μm³ and (10.53±0.24) μL/100 μm³, which were lower than those of the low osteotomy [(34.28±0.94) μL/100 μm³] and control group [(33.81±1.06) μL/100 μm³], all P < 0.05. The Reuter score of the low, middle, and high osteotomy groups [(2.38±0.34) points, (7.25±0.42) points, (9.56±0.73) points] were significantly higher than those of the control group[(1.39±0.25) points, all P < 0.05]. Conclusion Vertebral osteotomy has a good clinical effect. Shorter spine shortening has little effect on spinal-cord function. In clinical practice, attention should be paid to the critical value of safe osteotomy.
- Spinal shortening /
- Spinal cord function /
- Spinal-cord blood flow

HTML全文

表 1 各组家兔硬膜皱缩情况比较(x ±s)

Table 1. Comparison of dural shrinkage in rabbits in each group (x ±s)

组别	例数	硬膜囊横径(mm)	硬膜囊迂曲角(°)
对照组	10	4.39±0.11	0
低截骨组	10	4.85±0.32	0
中截骨组	10	5.74±0.29^a	14.46±0.77^a
高截骨组	10	7.65±0.36^a	85.62±2.95^a
F值		253.300	7 223.000
P值		< 0.001	< 0.001
注：与对照组比较，^aP＜0.05。

下载: 导出CSV

表 2 各组家兔Reuters评分比较(x ±s，分)

Table 2. Comparison of Reuters scores of rabbits in each group (x ±s, points)

组别	例数	术前Reuters评分	术后Reuters评分
对照组	10	0	1.39±0.25
低截骨组	10	0	2.38±0.34^a
中截骨组	10	0	7.25±0.42^a
高截骨组	10	0	9.56±0.73^a
F值			686.200
P值			< 0.001
注：与对照组比较，^aP＜0.05。

下载: 导出CSV

表 3 各组家兔脊髓血流量比较(x ±s，μL/100 μm³)

Table 3. Comparison of spinal cord blood flow of rabbits in each group (x ±s, μL/100 μm³)

组别	例数	脊髓血流量
对照组	10	33.81±1.06
低截骨组	10	34.28±0.94
中截骨组	10	27.66±0.85^a
高截骨组	10	10.53±0.24^a
F值		1 771.520
P值		< 0.001
注：与对照组比较，^aP＜0.05。

下载: 导出CSV

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