长链非编码RNA对急性痛风性关节炎相关信号通路的作用探讨

鲍艳媛; 郗域江; 高嘉美; 张丽萍; 谢招虎; 李兆福

doi:10.16766/j.cnki.issn.1674-4152.002647

长链非编码RNA对急性痛风性关节炎相关信号通路的作用探讨

doi: 10.16766/j.cnki.issn.1674-4152.002647

云南中医药大学第一临床医学院风湿免疫科，云南昆明 650500

基金项目:

国家自然科学基金项目 81760868

详细信息

通讯作者:
李兆福, E-mail: lzf0817@126.com

中图分类号: R589.7
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- 被引次数: 0
出版历程
- 收稿日期: 2021-12-07
- 网络出版日期: 2022-11-29

Role of long noncoding RNA on signaling pathways related to acute gout arthritis

Department of Rheumatology, the First Clinical Medical College, Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan 650500, China

摘要

摘要: 长链非编码RNA(long non-coding RNA, lncRNA)是通过调控邻近基因的表达来发挥作用的一类长度大于200个核苷酸的非编码RNA，无蛋白质编码功能，但是可以与蛋白质的多个位点结合，通过碱基互补配对原则与DNA、RNA发生特异性作用。近年来，随着基因检测技术的快速发展，lncRNA与多种免疫系统疾病的关系逐渐被人们所认识。痛风属于免疫系统疾病的范畴，因人体嘌呤代谢、尿酸生成与排泄异常，导致尿酸盐晶体沉积于组织或器官引发炎症反应，从而引起受累部位的剧烈疼痛，难以耐受。随着生活水平的提高和饮食结构的变化，痛风的发病率愈来愈高，严重影响患者的生活质量。目前，有研究指出，lncRNA与痛风的发病密切相关，痛风发作所涉及的炎症信号通路主要以Toll样受体(Toll-like receptors，TLRs)信号通路、Nod样受体蛋白3(Nod-like receptor protein 3)炎性小体信号通路及嘌呤受体P2X7(purinergic 2X7 receptor，P2X7R)信号通路为主，lncRNA除了通过调控免疫细胞参与痛风的发作，还通过影响上述信号通路发挥作用，本文主要就lncRNA与急性痛风性关节炎相关的信号通路及上述因子的关系进行探讨，进一步揭示痛风的发病机制，以期为痛风的防治提供新的方向。
- 长链非编码RNA /
- 痛风 /
- 炎性反应 /
- 信号通路 /
- 免疫调节
Abstract: Long non-conding RNA (lncRNA) is a kind of noncoding RNA more than 200 nucleotides long. It plays a role in regulating the expression of neighboring genes. It has no protein-coding function but can bind to multiple sites of protein. Specific interaction with DNA and RNA occurs through the principle of base complementary pairing. In recent years, with the rapid development of gene-detection technology, the relationship between lncRNA and various immune-system diseases has been gradually recognised. Gout belongs to the category of immune-system diseases. Owing to abnormal purine metabolism and uric acid production and excretion in the human body, urate crystals deposit in tissues or organs and trigger inflammatory reactions, thereby causing severe pain on the affected site and difficulty toleration. With the improvement in living standard and the change of diet structure, the incidence of gout is increasing, thereby seriously affecting people ' s life quality. Studies have pointed out that lncRNA is closely related to the onset of gout, and the inflammatory signaling pathways involved in gout attack are primarily the toll-like receptor signaling pathway, nod-like receptor protein 3 inflammasome signaling pathway, and Purinergic 2X7 receptor signaling pathway. In addition to regulating immune cells to participate in the onset of gout, lncRNA also plays a role by affecting the above signal pathways. This article primarily discusses the relationship between lncRNA and signal pathways and factors related to acute gout arthritis, further revealing the pathogenesis of gout, to provide a new direction for the prevention and treatment of gout.
- Long noncoding RNA /
- Gout /
- Inflammatory response /
- Signal pathway /
- Immune regulation

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