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陈氏调经汤联合芬吗通治疗肝肾阴虚型卵巢早衰的临床疗效观察

张文瑜 吴欢

张文瑜, 吴欢. 陈氏调经汤联合芬吗通治疗肝肾阴虚型卵巢早衰的临床疗效观察[J]. 中华全科医学, 2022, 20(11): 1934-1937. doi: 10.16766/j.cnki.issn.1674-4152.002739
引用本文: 张文瑜, 吴欢. 陈氏调经汤联合芬吗通治疗肝肾阴虚型卵巢早衰的临床疗效观察[J]. 中华全科医学, 2022, 20(11): 1934-1937. doi: 10.16766/j.cnki.issn.1674-4152.002739
ZHANG Wen-yu, WU Huan. Clinical observation of Chen' s Menstrual Conditioning Soup combined with femostone on premature ovarian failure of liver and kidney Yin deficiency syndrome[J]. Chinese Journal of General Practice, 2022, 20(11): 1934-1937. doi: 10.16766/j.cnki.issn.1674-4152.002739
Citation: ZHANG Wen-yu, WU Huan. Clinical observation of Chen' s Menstrual Conditioning Soup combined with femostone on premature ovarian failure of liver and kidney Yin deficiency syndrome[J]. Chinese Journal of General Practice, 2022, 20(11): 1934-1937. doi: 10.16766/j.cnki.issn.1674-4152.002739

陈氏调经汤联合芬吗通治疗肝肾阴虚型卵巢早衰的临床疗效观察

doi: 10.16766/j.cnki.issn.1674-4152.002739
基金项目: 

浙江省教育厅一般科研项目 Y201942331

浙江省中医药科技计划项目 2019ZB066

详细信息
    通讯作者:

    张文瑜, E-mail: zhangwenyulby@sina.com

  • 中图分类号: R242  R271

Clinical observation of Chen' s Menstrual Conditioning Soup combined with femostone on premature ovarian failure of liver and kidney Yin deficiency syndrome

  • 摘要:   目的  回顾性分析陈氏调经汤联合芬吗通治疗肝肾阴虚型卵巢早衰的临床疗效。  方法  对2019年1月—2021年1月浙江中医药大学附属第三医院收治的40例肝肾阴虚型卵巢早衰患者进行回顾性分析,根据治疗方法分为芬吗通治疗组(对照组,17例)及芬吗通联合陈氏调经汤治疗组(观察组,23例),6个月后观察治疗效果。  结果  治疗后,观察组各项中医证候积分均低于对照组(均P<0.05);观察组治疗效果优于对照组(Z=-2.455,P<0.05);观察组血清促卵泡生成素(FSH)、黄体生成素(LH)水平[(19.21±4.57)IU/L、(20.44±3.10)IU/L]低于对照组[(22.78±4.69)IU/L、(23.17±3.44)IU/L, 均P<0.05];观察组雌二醇(E2)水平为(69.22±12.39)pmol/L,高于对照组[(60.98±11.22)pmol/L, P<0.05];观察组卵巢体积、窦卵泡数(AFC)、卵巢动脉收缩期峰值血流速度(PSV)高于对照组,阻力指数(RI)、加速时间(TA)低于对照组(均P<0.05)。  结论  陈氏调经汤联合芬吗通治疗肝肾阴虚型卵巢早衰疗效显著,可有效缓解临床症状,促进性激素水平恢复,改善卵巢功能。

     

  • 表  1  2组肝肾阴虚型卵巢早衰患者基线资料比较(x±s)

    Table  1.   Comparison of baseline data of patients with Hepatorenal Yin deficiency premature ovarian failure between the two groups (x±s)

    组别 例数 年龄(岁) BMI 病程(月) 孕次(次)
    对照组 17 33.15±5.22 23.46±2.14 16.83±5.18 1.46±0.81
    观察组 23 33.06±4.18 23.28±2.22 16.30±5.34 1.50±0.79
    t 0.061 0.257 0.314 0.157
    P 0.952 0.798 0.755 0.876
    下载: 导出CSV

    表  2  2组肝肾阴虚型卵巢早衰患者中医证候积分比较(x±s,分)

    Table  2.   Comparison of TCM syndrome scores of patients with Liver and Kidney Yin deficiency type premature ovarian failure between the two groups (x±s, points)

    组别 例数 潮热汗出 腰膝酸软 阴道干涩 口干咽燥
    治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后
    对照组 17 2.20±0.34 1.51±0.22a 1.96±0.25 1.44±0.20a 1.80±0.27 1.25±0.19a 2.14±0.22 1.31±0.15a
    观察组 23 2.21±0.30 1.18±0.20a 1.98±0.23 1.26±0.17a 1.76±0.25 1.13±0.10a 2.10±0.23 1.20±0.11a
    t 0.098 4.945 0.262 3.071 0.488 2.590 0.554 2.679
    P 0.922 < 0.001 0.795 0.004 0.631 0.014 0.583 0.011
    组别 例数 头晕耳鸣 五心烦热 食欲不振 毛发脱落
    治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后
    对照组 17 1.67±0.24 1.14±0.17a 1.98±0.18 1.22±0.13a 1.68±0.18 1.36±0.11a 1.50±0.16 1.22±0.14a
    观察组 23 1.71±0.23 0.91±0.13a 2.04±0.21 1.04±0.08a 1.66±0.15 1.18±0.10a 1.48±0.11 1.09±0.08a
    t 0.534 4.853 0.948 5.410 0.383 5.394 0.469 3.717
    P 0.597 < 0.001 0.349 < 0.001 0.704 < 0.001 0.642 0.001
    注:与同组治疗前比较,aP < 0.05。
    下载: 导出CSV

    表  3  2组肝肾阴虚型卵巢早衰患者治疗效果比较[例(%)]

    Table  3.   Comparison of therapeutic effect between the two groups of patients with Hepatorenal Yin deficiency type premature ovarian failure [cases (%)]

    组别 例数 显效 有效 无效 有效率
    对照组 17 6(35.29) 8(47.06) 3(17.65) 14(82.35)
    观察组 23 17(73.91) 5(21.74) 1(4.35) 22(95.65)
    统计量 -2.455a 1.921b
    P 0.030 0.166
    注:aZ值,b为χ2值。
    下载: 导出CSV

    表  4  2组肝肾阴虚型卵巢早衰患者性激素水平比较(x±s)

    Table  4.   Comparison of sex hormone levels in patients with Hepatorenal Yin deficiency premature ovarian failure between the two groups (x±s)

    组别 例数 FSH(IU/L) LH(IU/L) E2(pmol/L)
    治疗前 治疗后 治疗前 治疗后 治疗前 治疗后
    对照组 17 40.60±9.24 22.78±4.69a 30.48±6.52 23.17±3.44a 40.77±10.16 60.98±11.22a
    观察组 23 40.15±10.08 19.21±4.57a 30.80±6.33 20.44±3.10a 41.23±10.59 69.22±12.39a
    t 0.145 2.415 0.156 2.628 0.138 2.163
    P 0.886 0.021 0.877 0.012 0.891 0.037
    注:与同组治疗前比较,aP < 0.05。
    下载: 导出CSV

    表  5  2组肝肾阴虚型卵巢早衰患者卵巢体积及卵巢血流动力学参数比较(x±s)

    Table  5.   Comparison of ovarian volume and hemodynamic parameters of the two groups of patients with hepatorenal Yin deficiency premature ovarian failure (x±s)

    组别 例数 卵巢体积(cm3) AFC(个) PSV(m/s) RI TA(s)
    治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后 治疗前 治疗后
    对照组 17 2.35±0.55 5.33±1.65a 4.43±1.18 6.92±1.66a 6.24±1.90 8.09±2.46a 0.73±0.15 0.66±0.09a 0.11±0.03 0.07±0.02a
    观察组 23 2.37±0.58 6.44±1.78a 4.29±1.22 8.55±1.80a 6.33±2.21 9.78±2.69a 0.72±0.17 0.60±0.08a 0.12±0.03 0.05±0.01a
    t 0.110 2.010 0.364 2.925 0.135 2.036 0.193 2.224 1.042 4.157
    P 0.913 0.052 0.718 0.006 0.893 0.049 0.848 0.032 0.304 < 0.001
    注:与同组治疗前比较,aP < 0.05。
    下载: 导出CSV
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  • 收稿日期:  2021-12-29
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