磁共振结肠成像与粪钙卫蛋白联合诊断溃疡性结肠炎的临床研究

黄洪; 许宝才

doi:10.16766/j.cnki.issn.1674-4152.002779

磁共振结肠成像与粪钙卫蛋白联合诊断溃疡性结肠炎的临床研究

doi: 10.16766/j.cnki.issn.1674-4152.002779

黄洪^1, ,,
许宝才²

1.
衢州市中医医院放射科，浙江衢州 324002
2.
衢州市中医医院消化科

基金项目:

浙江省中医药科技计划项目 2021ZB327

详细信息

通讯作者:
黄洪，E-mail：hhzdhjy@163.com

中图分类号: R574.62 R445.2
计量
- 文章访问数: 177
- HTML全文浏览量: 59
- PDF下载量: 8
- 被引次数: 0
出版历程
- 收稿日期: 2022-08-29
- 网络出版日期: 2023-02-07

Study on the magnetic resonance colonography combined with fecal calprotectin in the diagnosis of ulcerative colitis

HUANG Hong^{1
, ,},
XU Bao-cai²

1.
Department of Radiology, Quzhou Hospital of Traditional Chinese Medicine, Quzhou, Zhejiang 324002, China

摘要

摘要: 目的观察磁共振结肠成像(MRC)与粪钙卫蛋白(FC)联合用于溃疡性结肠炎(UC)诊断及病情评估的临床价值。方法以2019年6月—2022年6月衢州市中医医院收治的80例UC患者和80例同期健康受试者为研究对象，均进行结肠镜、MRC检查和FC检测。比较不同活动程度UC患者及健康受试者MRC影像特征及FC含量差异，以结肠镜检查结果为金标准，评价MRC影像特征评分、FC含量及两者联合诊断UC的诊断效能。结果健康受试者及不同活动程度UC患者出现黏膜强化、肠壁增厚、肠壁分层强化、梳齿征、肠壁淋巴结肿大、黏膜及黏膜下层缺损和DWI信号增强等MRC影像特征比例差异均有统计学意义(均P < 0.05)，且不同UC活动程度患者肠壁分层强化、梳齿征、肠壁淋巴结肿大等MRC影像特征出现比例差异均有统计学意义(均P < 0.05)。健康受试者及不同活动程度UC患者FC比较差异有统计学意义(P < 0.01)，UC患者FC为(3 186.11±291.80)μg/g，显著高于健康受试者[(2 699.47±249.67)μg/g, P < 0.05]，而不同活动程度UC患者之间FC比较差异无统计学意义(P>0.05)。MRC影像特征评分、FC、MRC影像特征评分联合FC诊断UC的ROC曲线下面积分别为0.956、0.895、0.984。结论 MRC和FC作为2种无创诊断技术，可作为结肠镜病理检查的替代或辅助手段用于UC的诊断和病情评估，且两者联合应用可提高UC的诊断效能。
- 溃疡性结肠炎 /
- 结肠镜检查 /
- 磁共振结肠成像 /
- 粪钙卫蛋白 /
- 活动度 /
- 诊断效能
Abstract: Objective To observe the clinical value of magnetic resonance colonography (MRC) combined with fecal calprotectin (FC) in the diagnosis and evaluation of ulcerative colitis (UC). Methods A total of 80 UC patients and 80 healthy subjects during the same period admitted to Quzhou Hospital of Traditional Chinese Medicine from June 2019 to June 2022 were selected as the research objects. All the subjects were examined by colonoscopy, MRC and FC. The MRC image characteristics and FC content of UC patients with different activity levels and healthy subjects were compared. The results of colonoscopy were used as the gold standard to evaluate the efficacy of MRC imaging feature score, FC content and their combination in the diagnosis of UC. Results There were statistically significant differences in the proportions of MRC imaging features such as mucosal enhancement, intestinal wall thickening, intestinal wall layering enhancement, comb tooth sign, intestinal wall lymph node enlargement, mucosal and submucosal defects and DWI signal enhancement in healthy subjects and UC patients with different activity levels (all P < 0.05), and there were statistically significant differences in the proportion of MRC imaging features such as intestinal wall stratification enhancement, comb tooth sign, intestinal wall lymph node enlargement in UC patients with different activity levels (P < 0.05). The difference of FC content between healthy subjects and UC patients with different activity levels was statistically significant (P < 0.01). The FC content of UC patients was (3 186.11±291.80) μg/g, significantly higher than that of healthy subjects [(2 699.47±249.67) μg/g, P < 0.05], while the FC content in UC patients with different activity levels was not statistically significant (P>0.05). The area under the ROC curve of MRC image feature score, FC content and MRC image feature score combined with FC content in diagnosing UC were 0.956, 0.895 and 0.984, respectively. Conclusion MRC and FC, as two non-invasive diagnostic techniques, can be used as an alternative or auxiliary means of colonoscopy pathology for UC diagnosis and disease evaluation. The combined application of MRC and FC can improve the diagnostic efficiency of UC.
- Ulcerative colitis /
- Colonoscopy /
- Magnetic resonance colonography /
- Fecal calprotectin /
- Activity /
- Diagnostic efficacy

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图 1 MRC影像特征评分及FC诊断UC的ROC曲线

Figure 1. ROC curve of MRC image feature score and FC content in diagnosis of UC

下载: 全尺寸图片幻灯片

表 1 健康受试者及不同活动程度UC患者MRC影像特征比较[例(%)]

Table 1. Comparison of MRC image characteristics between healthy subjects and UC patients with different degrees of activity [cases (%)]

组别	例数	黏膜强化	肠壁增厚	肠壁分层强化	梳齿征	肠壁淋巴结肿大	黏膜及黏膜下层缺损	DWI信号增强
健康受试者	80	23(28.75)	27(33.75)	13(16.25)	15(18.75)	8(10.00)	10(12.50)	19(23.75)
轻度UC	26	23(88.46)	24(92.31)	11(42.31)	14(53.85)	9(34.62)	17(65.38)	21(80.77)
中度UC	35	32(91.43)	33(94.28)	24(68.57)	27(77.14)	20(57.14)	25(71.43)	30(85.71)
重度UC	19	18(94.74)	18(94.74)	18(94.74)	17(89.47)	14(73.68)	14(73.68)	17(89.47)
χ²值		10.788	18.968	53.854	52.739	43.304	54.936	60.836
P值		0.013	＜0.001	＜0.001	＜0.001	＜0.001	＜0.001	＜0.001

下载: 导出CSV

表 2 MRC影像特征评分及FC诊断UC的ROC曲线分析

Table 2. ROC curve analysis of MRC image feature score and FC content in diagnosis of UC

诊断方式	AUC	SE	P值	渐近95% CI
MRC影像特征评分	0.956	0.013	< 0.001	0.930~0.983
FC含量	0.895	0.024	< 0.001	0.849~0.942
MRC影像特征评分联合FC含量	0.984	0.007	< 0.001	0.971~0.998

下载: 导出CSV

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