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无机碘口服在Graves病中的研究进展

王心盼 赵成程 李璐阳 郑旭琴

王心盼, 赵成程, 李璐阳, 郑旭琴. 无机碘口服在Graves病中的研究进展[J]. 中华全科医学, 2022, 20(12): 2110-2113. doi: 10.16766/j.cnki.issn.1674-4152.002781
引用本文: 王心盼, 赵成程, 李璐阳, 郑旭琴. 无机碘口服在Graves病中的研究进展[J]. 中华全科医学, 2022, 20(12): 2110-2113. doi: 10.16766/j.cnki.issn.1674-4152.002781
WANG Xin-pan, ZHAO Cheng-cheng, LI Lu-yang, ZHENG Xu-qin. Research progress of oral inorganic iodine for Graves' disease[J]. Chinese Journal of General Practice, 2022, 20(12): 2110-2113. doi: 10.16766/j.cnki.issn.1674-4152.002781
Citation: WANG Xin-pan, ZHAO Cheng-cheng, LI Lu-yang, ZHENG Xu-qin. Research progress of oral inorganic iodine for Graves' disease[J]. Chinese Journal of General Practice, 2022, 20(12): 2110-2113. doi: 10.16766/j.cnki.issn.1674-4152.002781

无机碘口服在Graves病中的研究进展

doi: 10.16766/j.cnki.issn.1674-4152.002781
基金项目: 

江苏省研究生科研与实践创新计划项目 SJCX22_0681

江苏省研究生科研与实践创新计划项目 SJCX20_0494

详细信息
    通讯作者:

    郑旭琴,E-mail:zhengxuqin@njmu.edu.cn

  • 中图分类号: R581.3

Research progress of oral inorganic iodine for Graves' disease

  • 摘要: 碘是人体内重要微量元素之一,是甲状腺激素合成的基本原料。口服的无机碘分为膳食碘和治疗碘,与甲状腺免疫和代谢密切相关。Graves病(Graves ' disease,GD)又称弥漫性毒性甲状腺肿,表现为甲状腺功能亢进及高碘代谢状态,临床上常建议Graves病患者限碘甚至忌碘饮食。最新的研究进展显示膳食碘对于抗甲状腺药物治疗的干扰性可能被高估,放射性碘治疗之前严格限制无机碘、择期手术之前强制使用无机碘都不是必需的。此外,无机碘可以作为Graves病的治疗药物,在具有轻型甲亢、低甲状腺自身抗体浓度、较小的甲状腺体积、高碘饮食等特点的患者中探索性应用无机碘显示出不错的成效。当传统的抗甲状腺药物出现副作用而患者仍倾向保守治疗时,无机碘或许能作为替代选择。无机碘因低致畸性、低血液毒性和低骨髓毒性,可以在特殊人群如妊娠期、哺乳期和肿瘤放化疗期的患者中发挥独特作用。本文对膳食碘和治疗碘的研究进程、生物学功能、适用人群及特定情形下的应用进行汇总,旨在为Graves病的诊治提供参考,丰富Graves病患者的诊疗策略以及进一步提高Graves病患者的生存质量。

     

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出版历程
  • 收稿日期:  2022-05-10
  • 网络出版日期:  2023-02-07

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