高压氧联合醒脑静注射液对创伤性脑损伤昏迷患者意识改善及血清SOD、NO的影响

王自成; 齐胤良; 许季祥; 李伟; 周小妹

doi:10.16766/j.cnki.issn.1674-4152.002846

高压氧联合醒脑静注射液对创伤性脑损伤昏迷患者意识改善及血清SOD、NO的影响

doi: 10.16766/j.cnki.issn.1674-4152.002846

王自成^{1, 2},
齐胤良²,
许季祥²,
李伟³,
周小妹^{1, 2, ,}

1.
蚌埠医学院研究生院，安徽蚌埠 233030
2.
合肥市第二人民医院(安徽医科大学附属合肥医院)高压氧科，安徽合肥 230011
3.
蚌埠医学院第一附属医院呼吸内科，安徽蚌埠 233004

基金项目:

蚌埠医学院自然科学重点项目 2020byzd309

2021年第一批安徽省中央引导地方科技发展资金项目 2020b07030008

合肥市中医药研究项目 202234-4

详细信息

通讯作者:
周小妹，E-mail: xiaomeizhou1222@yahoo.com

中图分类号: R651.15 R459.6
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- 被引次数: 0
出版历程
- 收稿日期: 2022-08-05

Effects of hyperbaric oxygen combined with Xingnaojing injection on the consciousness improvement and serum SOD and NO in comatose patients with traumatic brain injury

1.
Graduate School of Bengbu Medical College, Bengbu, Anhui 233030, China

摘要

摘要: 目的探讨临床治疗创伤性脑损伤(TBI)昏迷患者, 单用醒脑静注射液与高压氧联合醒脑静注射液的2种治疗方式对于患者意识改善及血清中氧化应激指标水平的影响。方法采用回顾性调查研究法，整理2021年5月1日—2022年1月31日在合肥市第二人民医院高压氧科及神经外科治疗的56例重度TBI昏迷患者的临床资料，根据在院期间患者是否接受高压氧治疗分为高压氧治疗组(观察组)32例和未接受高压氧治疗组(对照组)24例。利用格拉斯哥昏迷量表(GCS)对2组患者治疗前后意识状态进行评估并记录，检测2组治疗前、治疗第10天、治疗第20天血清超氧化物歧化酶(SOD)、一氧化氮(NO)水平并记录患者苏醒率。结果治疗后，2组患者GCS评分均较治疗前增高(均P < 0.05)，观察组GCS评分为(9.22±2.27)分，明显高于对照组[(7.71±2.77)分，P < 0.05]；且观察组苏醒率[59.4%(19/32)]明显高于对照组[29.2%(7/24), P < 0.05]。2组治疗前、治疗第10天和第20天的SOD值均依次上升。2组治疗前、治疗第10天和第20天的NO值均依次下降。结论高压氧联合醒脑静注射液治疗创伤性脑损伤昏迷患者可更明显地改善患者意识状态，提升苏醒率，其可能的作用机制与血清SOD水平升高及血清NO水平下降有关。
- 高压氧 /
- 创伤性脑损伤 /
- 超氧化物歧化酶 /
- 一氧化氮 /
- 醒脑静注射液
Abstract: Objective This study aims to investigate the effects of two therapeutic methods of Xingnaojing injection alone and hyperbaric oxygen combined with Xingnaojing injection on the improvement of consciousness and the levels of SOD and NO in serum of patients with coma caused by traumatic brain injury (TBI). Methods The clinical data of 56 patients with severe TBI coma who were treated in the hyperbaric oxygen department and neurosurgery department of Hefei Second People ' s Hospital from May 1, 2021 to January 31, 2022 were collected by retrospective investigation. The patients were divided into the hyperbaric oxygen treatment group (observation group) and non-hyperbaric oxygen treatment group (control group) based on whether they received hyperbaric oxygen treatment during the hospital period, including 32 patients in the observation group and 24 patients in the control group. The Glasgow coma scale (GCS) was used to assess and record the consciousness status in the two groups of patients before and after treatment. The levels of serum superoxide dismutase (SOD) and nitric oxide (NO) were measured before treatment, on the 10th and 20th days of treatment in 2 groups, meantime, the recovery rate of patients was recorded. Results The GCS score of the two groups after treatment was higher than that before treatment (all P < 0.05). The GCS score of the observation group after treatment increased to (9.22±2.27) points, which was significantly higher than that of the control group after treatment [(7.71±2.77) points, P < 0.05]. The recovery rate of the observation group [59.4% (19/32)] was significantly higher than that of the control group [29.2% (7/24), P < 0.05]. The SOD level of the two groups increased sequentially before treatment, on the 10th and 20th days of treatment. While, the NO level of the two groups decreased sequentially before treatment, on the 10th and 20th days of treatment. Conclusion Hyperbaric oxygen combined with Xingnaojing injection can significantly improve the consciousness of patients with coma caused by traumatic brain injury, and increase the recovery rate. Furthermore, its possible mechanism is related to the increase of serum SOD level and the decrease of serum NO level.
- Hyperbaric oxygen /
- Traumatic brain injury /
- Superoxide dismutase /
- Nitric oxide /
- Xingnaojing injection
利益冲突 无

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表 1 2组TBI昏迷患者治疗前后GCS评分比较(x±s，分)

Table 1. Comparison of GCS scores before and after treatment in two groups of coma patients with TBI (x±s, points)

组别	例数	治疗前	治疗后	t值	P值
对照组	24	6.46±1.77	7.71±2.77	3.907	0.001
观察组	32	6.56±1.59	9.22±2.27	7.933	＜0.001
t值		0.232	2.241
P值		0.818	0.029

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表 2 2组TBI昏迷患者治疗前后SOD水平比较(x±s，U/mL)

Table 2. Comparison of SOD level in two groups of TBI coma patients before and after treatment (x±s, U/mL)

组别	例数	治疗前	治疗第10天	治疗第20天	F值	P值
对照组	24	93.51±20.61	109.13±22.01	116.81±21.20	9.291	＜0.001
观察组	32	96.32±25.68	116.62±24.40	139.07±21.62	46.037	＜0.001
t值		0.193	1.403	14.777
P值		0.662	0.241	＜0.001

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表 3 2组TBI昏迷患者治疗前后NO水平比较(x±s，μmol/L)

Table 3. Comparison of NO levels in two groups of TBI coma patients before and after treatment (x±s, μmol/L)

组别	例数	治疗前	治疗第10天	治疗第20天	F值	P值
对照组	24	100.58±14.14	92.80±11.32	87.63±13.83	13.553	＜0.001
观察组	32	105.43±17.02	90.66±18.02	62.66±12.94	171.433	＜0.001
t值		1.280	0.260	48.166
P值		0.263	0.612	＜0.001

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