失眠与端粒长度和衰老的相关性研究进展

潘贤丽; 苏增锋

doi:10.16766/j.cnki.issn.1674-4152.002912

失眠与端粒长度和衰老的相关性研究进展

doi: 10.16766/j.cnki.issn.1674-4152.002912

潘贤丽,
苏增锋^,

安徽医科大学附属巢湖医院全科医学科，安徽巢湖 238000

基金项目:

安徽省教育厅高校自然科学研究重点项目 KJ2020A0189

安徽医科大学校科研基金项目 2020xkj219

详细信息

通讯作者:
苏增锋, E-mail：suzengfeng@163.com

中图分类号: R592
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- 被引次数: 0
出版历程
- 收稿日期: 2022-01-12
- 网络出版日期: 2023-04-19

Correlation between insomnia and telomere length and aging

PAN Xianli,
SU Zengfeng^,

Department of General Medicine, Chaohu Hospital Affiliated to Anhui Medical University, Chaohu, Anhui 238000, China

摘要

摘要: 睡眠是由大脑中的睡眠促进和唤醒中心调控的一种神经化学过程。随着年龄的增长，昼夜节律的稳定性降低，睡眠障碍的患病率增加。失眠是最常见的睡眠障碍，影响着数以百万计的人，对个人和社会都有着深远的影响。与青壮年相比，老年人的睡眠模式、睡眠时间和质量都发生了显著的变化，如睡眠片段化、早醒、慢波睡眠减少等，失眠的发生率明显升高。长期严重的失眠不仅给患者的生活质量造成影响，甚至与某些疾病的发病风险、死亡率增加有关。目前与年龄相关的睡眠模式改变的机制尚不完全清楚。然而，这并不意味着失眠是衰老的正常现象。端粒是真核生物染色体的末端，在转录过程中，其对染色体末端保护和基因组稳定性维护发挥着重要作用，同时在控制细胞衰老和机体衰老中起着核心作用。端粒长度的缩短或端粒结构的改变，最终会导致细胞的复制性衰老和染色体的不稳定性, 这两者都是衰老的标志。衰老是生命的必然结果，在大多数生物体中，衰老的速度与平均寿命成反比。年龄增长也是癌症、神经退行性变和心血管疾病的最大危险因素。目前有关于失眠与端粒长度、衰老之间关系的两两研究，然而缺乏对三者之间的系统综述，本文将从失眠对端粒长度的影响、端粒长度对衰老的意义以及失眠对衰老的影响3个方面进行阐述。
- 失眠 /
- 端粒长度 /
- 衰老
Abstract: Sleep is a neurochemical process regulated by sleep promotion and arousal centres in the brain. Circadian rhythm stability decreases with age, and the prevalence of sleep disorders increases. Insomnia is the most common sleep disorder, and it affects millions of people and has profound consequences for individuals and society. The sleep pattern, sleep duration and quality of elderly have undergone significant changes, such as sleep fragmentation, early awakening, slow wave sleep reduction and significantly increased incidence of insomnia, compared with those of young and middle-aged individuals. Long-term serious insomnia not only affects the quality of life of patients but also increases the risk of some diseases and mortality. The mechanism of age-related changes in sleep patterns is not fully understood, and whether insomnia is a normal part of aging remains unclear. Telomeres are the ends of eukaryotic chromosomes that protect chromosome ends, maintain genome stability during transcription, and play a central role in the control of cell and body aging. Shortening of telomere length or changes in telomere structure can eventually lead to replicative senescence in cells and chromosomal instability, which are both markers of senescence. Aging is an inevitable consequence of life. In most organisms, the rate of aging is inversely proportional to average life span. Aging is also the biggest risk factor for cancer, neurodegeneration and cardiovascular diseases. Two studies were conducted on the relationship between insomnia and telomere length and aging, however, a systematic review of such studies is lacking. This paper will elaborate three aspects, namely, influence of insomnia on telomere length, significance of telomere length on aging and the effects of insomnia on aging.
- Insomnia /
- Telomere length /
- Aging

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