麦粒灸联合康复功能训练对退行性膝关节炎患者关节疼痛的作用

孙晓; 赵云; 张保安; 张盾盾; 刘强; 熊小云; 杨曼; 段春天; 刘会星

doi:10.16766/j.cnki.issn.1674-4152.002914

麦粒灸联合康复功能训练对退行性膝关节炎患者关节疼痛的作用

doi: 10.16766/j.cnki.issn.1674-4152.002914

1.
河南省直第三人民医院康复医学科, 河南郑州 450000
2.
河南省直第三人民医院中医科

基金项目:

河南省医学科技攻关计划项目 2018020579

详细信息

通讯作者:
孙晓, E-mail: yd96jv@163.com

中图分类号: R684.3 R245.81
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- 文章访问数: 232
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- 被引次数: 0
出版历程
- 收稿日期: 2022-02-18
- 网络出版日期: 2023-04-19

Effect of wheat grain moxibustion combined with rehabilitation function training on relieving joint pain in patients with degenerative knee arthritis

1.
Department of Rehabilitation Medicine, the Third People's Hospital of Henan Province, Zhengzhou, Henan 450000, China

摘要

摘要: 目的分析麦粒灸联合康复功能训练对退行性膝关节炎的作用。方法选取河南省直第三人民医院于2019年3月—2022年3月收治的退行性膝关节炎患者110例，采用随机数字表法分为对照组和观察组，各55例，对照组患者在常规治疗基础上给予康复功能训练，观察组在对照组基础上给予麦粒灸治疗，比较2组临床疗效。结果与对照组比较，观察组VAS评分[(3.51±1.62)分vs.(1.76±0.54)分]、肿瘤坏死因子-α[(29.25±3.17)ng/L vs.(23.75±2.86)ng/L]、白细胞介素6[(25.36±2.14)ng/L vs.(17.56±1.57)ng/L]、基质金属蛋白酶-1[(0.75±0.24)ng/L vs.(0.59±0.18)ng/L]、组织蛋白酶D[(153.25±28.34)pg/mL vs.(128.32±21.04)pg/mL]、基质金属蛋白酶-9[(15.24±2.54)mg/L vs.(11.05±2.17)mg/L]、基质金属蛋白酶组织抑制因子-1[(1.82±0.28)pg/mL vs.(1.54±0.16)pg/mL]水平低。观察组Lysholm膝关节评分表评分[(74.36±7.54)分vs.(82.24±8.25)分]、白细胞介素10[(27.82±5.21)ng/L vs.(34.24±6.05)ng/L]和总有效率高于对照组(均P＜0.05)。结论麦粒灸联合康复功能训练治疗退行性膝关节炎疗效显著。
- 退行性膝关节炎 /
- 麦粒灸 /
- 康复功能训练 /
- 关节疼痛 /
- 炎症因子
Abstract: Objective To analyze the effect of wheat grain moxibustion combined with rehabilitation function training on patients with degenerative knee arthritis. Methods A total of 110 patients of degenerative knee arthritis treated in the Third People's Hospital of Henan Province from March 2019 to March 2022 were selected as the research object. They were randomly divided into control group and observation group by random number table method, with 55 cases in each group. The control group was given rehabilitation training on the basis of routine treatment, and the observation group was given wheat grain moxibustion on the basis of the control group. The clinical efficacy was compared between the two groups. Results The visual analogue scale (VAS) score [(3.51±1.62) points vs. (1.76±0.54) points], tumor necrosis factor-α[(29.25±3.17) ng/L vs. (23.75±2.86) ng/L], interleukin-6 [(25.36±2.14) ng/L vs. (17.56±1.57) ng/L], matrix metalloproteinase-1 [(0.75±0.24)ng/L vs. (0.59±0.18)ng/L], cathepsin D[(153.25±28.34) pg/mL vs. (128.32±21.04) pg/mL], matrix metalloproteinase-9 [(15.24±2.54) mg/L vs. (11.05±2.17) mg/L] and matrix metalloproteinase tissue inhibitor-1 [(1.82±0.28) pg/mL vs. (1.54±0.16) pg/mL] in the observation group were lower than those in the control group, and Lysholm knee score [(74.36±7.54) points vs. (82.24±8.25) points], interleukin-10 [(27.82±5.21) ng/L vs. (34.24±6.05) ng/L] and clinical efficacy were higher than those in the control group (P < 0.05). Conclusion Wheat grain moxibustion combined with rehabilitation function training in the treatment of degenerative knee arthritis has a significant effect.
- Degenerative knee arthritis /
- Wheat grain moxibustion /
- Rehabilitation function training /
- Joint pain /
- Inflammatory factors

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表 1 2组退行性膝关节炎患者临床资料比较

Table 1. Comparison of clinical data between the two groups of patients with degenerative knee arthritis

组别	例数	性别(例)		年龄(x±s，岁)	发病位置(例)			病程(x±s，年)
组别	例数	男性	女性	年龄(x±s，岁)	左侧	右侧	双侧	病程(x±s，年)
对照组	55	26	29	51.29±5.68	18	23	14	2.47±0.36
观察组	55	21	34	52.23±4.56	14	25	16	2.51±0.42
统计量		0.929^a		0.957^b	0.717^a			0.536^b
P值		0.335		0.341	0.699			0.593
注：^a为χ²值，^b为t值。

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表 2 2组退行性膝关节炎患者VAS评分和LKSS评分比较(x±s，分)

Table 2. Comparison of VAS scores and LKSS scores between the two groups of patients with degenerative knee arthritis(x±s, points)

组别	例数	VAS评分		LKSS评分
组别	例数	治疗前	治疗后	治疗前	治疗后
对照组	55	6.35±1.58	3.51±1.62^a	53.26±6.25	74.36±7.54^a
观察组	55	6.32±1.54	1.76±0.54^a	53.78±6.32	82.24±8.25^a
t值		0.101	7.600	0.434	5.229
P值		0.920	＜0.001	0.665	＜0.001
注：与同组治疗前比较，^aP＜0.05。

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表 3 2组退行性膝关节炎患者炎性因子水平比较(x±s，ng/L)

Table 3. Comparison of inflammatory factor levels between the two groups of patients with degenerative knee arthritis(x±s, ng/L)

组别	例数	TNF-α		IL-6		IL-10
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	55	40.25±3.98	29.25±3.17^a	33.25±2.35	25.36±2.14^a	17.56±4.25	27.82±5.21^a
观察组	55	40.36±4.12	23.75±2.86^a	33.54±2.41	17.56±1.57^a	17.68±4.36	34.24±6.05^a
t值		0.142	9.554	0.639	21.795	0.146	5.963
P值		0.887	＜0.001	0.524	＜0.001	0.884	＜0.001
注：与同组治疗前比较，^aP＜0.05。

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表 4 2组膝关节炎患者退行性病变相关指标比较(x±s)

Table 4. Comparison of indicators related to degenerative lesions in patients with knee arthritis between the two groups(x±s)

组别	例数	MMP-1(ng/L)		CAT-D(pg/mL)		MMP-9(mg/L)		TIMP-1(pg/mL)
组别	例数	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后	治疗前	治疗后
对照组	55	0.96±0.31	0.75±0.24^a	219.25±35.26	153.25±28.34^a	26.31±3.14	15.24±2.54^a	2.04±0.35	1.82±0.28^a
观察组	55	0.98±0.34	0.59±0.18^a	218.35±34.52	128.32±21.04^a	26.24±3.08	11.05±2.17^a	2.05±0.37	1.54±0.16^a
t值		0.322	3.955	0.135	5.238	0.118	9.302	0.146	6.439
P值		0.748	＜0.001	0.893	＜0.001	0.906	＜0.001	0.884	＜0.001
注：与同组治疗前比较，^aP＜0.05。

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表 5 2组退行性膝关节炎患者临床总有效率比较[例(%)]

Table 5. Comparison of total clinical effective rate between the two groups of patients with degenerative knee arthritis [cases (%)]

组别	例数	痊愈	好转	有效	无效	总有效
对照组	55	23(41.81)	9(16.36)	14(25.45)	9(16.36)	46(83.64)
观察组	55	38(69.10)	10(18.18)	5(9.09)	2(3.64)	53(96.36)
注：2组总有效率比较，χ²=4.949，P=0.026。

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