急性脑梗死患者血清β-肌动蛋白与脑电图定量指标相关性分析

江峰; 金春园; 王波娜; 何松彬

doi:10.16766/j.cnki.issn.1674-4152.003027

急性脑梗死患者血清β-肌动蛋白与脑电图定量指标相关性分析

doi: 10.16766/j.cnki.issn.1674-4152.003027

1.
浙江省舟山医院脑电图室，浙江舟山 316000
2.
浙江省舟山医院神经内科

基金项目:

浙江省医药卫生科技计划项目 2022KY1367

详细信息

通讯作者:
何松彬，E-mail：1998hsb@163.com

中图分类号: R743.3 R741.044
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- 文章访问数: 235
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- PDF下载量: 5
- 被引次数: 0
出版历程
- 收稿日期: 2022-11-12
- 网络出版日期: 2023-08-26

Correlation analysis of serum β-actin and quantitative EEG indicators in patients with acute cerebral infarction

1.
Department of EEG Room, Zhoushan Hospital of Zhejiang Province, Zhoushan, Zhejiang 316000, China

摘要

摘要: 目的探讨急性脑梗死患者血清β-肌动蛋白和脑电图定量指标变化，分析二者的相关性。方法选择2021年6月—2022年6月浙江省舟山医院收治的60例急性脑梗死患者作为研究对象，轻度组24例，中度组24例，重度组12例；另选浙江省舟山医院同期健康体检者50人作为对照组。采用酶联免疫吸附法测定β-肌动蛋白水平；采用脑电图仪监测脑电图，计算DTABR值。结果脑梗死组β-肌动蛋白[(1.83±0.34)μg/L]和DTABR值(7.71±0.43)高于对照组[(0.64±0.12)μg/L和6.24±0.32]，t=23.542、19.991，均P＜0.05。重度组血清β-肌动蛋白[(2.29±0.41)μg/L]和DTABR值(8.54±0.47)高于中度组[(1.79±0.36)μg/L和7.68±0.42]与轻度组[(1.27±0.28)μg/L和6.63±0.34]，均P＜0.05；且中度组β-肌动蛋白水平和DTABR值高于轻度组(均P＜0.05)。经Pearson分析，β-肌动蛋白与DTABR值呈线性正相关关系(r=0.584，P=0.002)。经多因素logistic回归分析，β-肌动蛋白和DTABR值为脑梗死患者病情程度的影响因素。结论急性脑梗死患者β-肌动蛋白和DTABR值明显升高，与病情严重程度密切相关，且血清β-肌动蛋白水平与DTABR值呈正相关关系。
- 急性脑梗死 /
- β-肌动蛋白 /
- 脑电图定量 /
- 相关性
Abstract: Objective To explore the changes of serum β-actin and quantitative indicators EEG of acute cerebral infarction, and analyses its correlation. Methods A total of 60 patients with acute cerebral infarction from June 2021 to June 2022 in Zhoushan Hospital of Zhejiang Province were selected. There were 24 cases in mild group, 24 cases in moderate group and 12 cases in severe group; Another 50 cases of physical examination in the same period in Zhoushan Hospital of Zhejiang Province were selected as the control group. β-actin level measured by enzyme-linked immunosorbent assay. EEG was used to monitor patients ' EEG, and relative power value and power ratio index of each frequency band(DTABR) was calculated. Results The β-actin level [(1.83±0.34)μg/L] and DTABR value (7.71±0.43) in the cerebral infarction group were higher than those in the control group [(0.64±0.12)μg/L and 6.24±0.32], t=23.542, 19.991, both P < 0.05. The β-actin level [(2.29±0.41) μg/L] and DTABR value (8.54±0.47) in the severe group were higher than those in the moderate group [(1.79±0.36)μg/L and 7.68±0.42] and mild group [(1.27±0.28) μg/L and 6.63±0.34], all P < 0.05, while the β-actin level and DTABR value in the moderate group were higher than those in the mild group (all P < 0.05). The Pearson analysis showed that the level of β-actin was positively correlated with the DTABR value (r=0.584, P=0.002). Multivariate logistic regression analysis showed that β-actin and DTABR were the influencing factors for patients with cerebral infarction. Conclusion Serum β-actin level and DTABR value in patients with acute cerebral infarction significantly increase, which are closely related to the severity of the disease, and the level of β-actin is positively correlated with the value of DTABR.
- Acute cerebral infarction /
- β-actin /
- Electroencephalogram quantification /
- Correlation

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表 1 2组研究对象血清β-肌动蛋白水平和DTABR值比较(x ±s)

Table 1. Comparison of serum β-actin levels and DTABR values between the two groups (x ±s)

组别	例数	β-肌动蛋白(μg/L)	DTABR值
脑梗死组	60	1.83±0.34	7.71±0.43
对照组	50	0.64±0.12	6.24±0.32
t值		23.542	19.991
P值		＜0.001	＜0.001

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表 2 不同病情程度脑梗死患者血清β-肌动蛋白水平和DTABR值比较(x ±s)

Table 2. Comparison of serum β-actin levels and DTABR values in patients with different severity of cerebral infarction (x ±s)

病情程度	例数	β-肌动蛋白(μg/L)	DTABR值
重度组	12	2.29±0.41^ab	8.54±0.47^ab
中度组	24	1.79±0.36^a	7.68±0.42^a
轻度组	24	1.27±0.28	6.63±0.34
F值		37.766	98.611
P值		＜0.001	＜0.001
注：与轻度组比较，^aP＜0.05；与中度组比较，^bP＜0.05。

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表 3 急性脑梗死患者β-肌动蛋白水平和DTABR值多因素logistic回归分析

Table 3. Multivariate logistic regression analysis of β-actin level and DTABR value in patients with acute cerebral infarction

变量	B	SE	Waldχ²	P值	OR值	95% CI
β-肌动蛋白	1.672	0.637	6.890	0.009	5.323	1.527~18.551
DTABR值	1.418	0.647	4.803	0.028	4.129	1.162~14.675
注：因变量为急性脑梗死(未发生=0，发生=1)；自变量为β-肌动蛋白(≤1.83 μg/L=0，>1.83 μg/L=1)和DTABR值(≤7.71=0，>7.71=1)。

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参考文献(20)

[1]	LI G, HAN C, XIA X P, et al. Relationship of uric acid, C-reactive protein, and N-terminal pro-B-type natriuretic peptide with acute cerebral infarction[J]. Rev Assoc Med Bras, 2021, 67(11): 1639-1643. doi: 10.1590/1806-9282.20210693
[2]	黄颖, 胡存昆. 血清ANGPTL4、VE-cadherin水平与急性脑梗死患者颈动脉易损斑块的关系[J]. 中南医学科学杂志, 2022, 50(5): 762-764. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYY202205035.htm HUANG Y, HU C K. Relationship between the levels of serum ANGPTL4, VE-cadherin and carotid plaque in patients with acute cerebral infarction[J]. Medical Science Journal of Central South China, 2022, 50(5): 762-764. https://www.cnki.com.cn/Article/CJFDTOTAL-HYYY202205035.htm
[3]	梁菊萍, 杨旸, 董继存. 急性脑梗死患者流行病学调查及危险因素[J]. 中国老年学杂志, 2021, 41(12): 2484-2487. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202112007.htm LIANG J P, YANG Y, DONG J C. Epidemiological investigation and risk factors of patients with acute cerebral infarction[J]. Chinese Journal of Gerontology, 2021, 41(12): 2484-2487. https://www.cnki.com.cn/Article/CJFDTOTAL-ZLXZ202112007.htm
[4]	施德, 刘振国, 王文安, 等. 老年急性轻型脑卒中患者中陈旧性腔隙性脑梗死的流行病学调查[J]. 河北医药, 2020, 42(20): 3166-3169. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYZ202020031.htm SHI D, LIU Z G, WANG W A, et al. Epidemiological investigation of old lacunar infarction in elderly patients with acute mild cerebral stroke[J]. Hebei Medical Journal, 2020, 42(20): 3166-3169. https://www.cnki.com.cn/Article/CJFDTOTAL-HBYZ202020031.htm
[5]	黎建乐, 王莹, 冯慧宇, 等. 广东省脑卒中流行病学调查[J]. 中国神经精神疾病杂志, 2020, 46(1): 1-7. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSJJ202001001.htm LI J L, WANG Y, FENG H Y, et al. Epidemiology of stroke in Guangdong province, China[J]. Chinese Journal of Nervous and Mental Diseases, 2020, 46(1): 1-7. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSJJ202001001.htm
[6]	莫延红, 王长玉, 孔朝红, 等. 急性心源性大面积脑梗死患者定量脑电图参数与预后的相关性分析[J]. 卒中与神经疾病, 2020, 27(3): 316-322. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYS202003008.htm MO Y H, WANG Z Y, KONG C H, et al. Correlation analysis between quantitative EEG parameters and clincal prognosis in patients with acute cardiogenic large area cerebral infarction[J]. Correlation analysis between quantitative EEG parameters and clincal prognosis in patients with acute cardiogenic large area cerebral infarction, 2020, 27(3): 316-322. https://www.cnki.com.cn/Article/CJFDTOTAL-ZZYS202003008.htm
[7]	赵瑶, 章鹏, 李小玉. DSA引导下神经介入取栓术治疗急性脑梗死的临床效果及对血流动力学和血管内皮功能的影响[J]. 中国急救复苏与灾害医学杂志, 2022, 17(10): 1304-1307. https://www.cnki.com.cn/Article/CJFDTOTAL-YTFS202210010.htm ZHAO Y, ZHANG P, LI X Y. Clinical effect of DSA-guided nerve interventional thrombus removal in treatment of acute cerebral infarction and its influence on hemodynamics and vascular endothelial function[J]. China Journal of Emergency Resuscitation and Disaster Medicine, 2022, 17(10): 1304-1307. https://www.cnki.com.cn/Article/CJFDTOTAL-YTFS202210010.htm
[8]	裴晴. 不同预后的急性脑梗死患者弥散加权成像表观弥散系数的变化及其与神经损害程度血清细胞因子的相关性[J]. 中国药物与临床, 2020, 20(13): 2115-2118. https://www.cnki.com.cn/Article/CJFDTOTAL-YWLC202013003.htm PEI Q. Changes of DWI apparent diffusion coefficient in patients with acute cerebral infarction with different prognosis and its correlation with nerve damage and serum cytokines[J]. Chinese Remedies & Clinics, 2020, 20(13): 2115-2118. https://www.cnki.com.cn/Article/CJFDTOTAL-YWLC202013003.htm
[9]	苏健, 徐冰, 宋媛, 等. 脑梗死患者血清炎性因子、同型半胱氨酸与颈动脉内膜中层厚度的关系[J]. 检验医学, 2020, 35(8): 852-853. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYY202008028.htm SU J, XU B, SONG Y, et al. Relationship between serum inflammatory factors, homocysteine and carotid intima-media thickness in patients with cerebral infarction[J]. Laboratory Medicine, 2020, 35(8): 852-853. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYY202008028.htm
[10]	张俊湖, 卓军, 巩利, 等. 血清炎性因子和神经细胞因子水平与老年后循环脑梗死患者椎动脉斑块形成及斑块稳定性的关系[J]. 临床和实验医学杂志, 2021, 20(10): 1066-1069. https://www.cnki.com.cn/Article/CJFDTOTAL-SYLC202110016.htm ZHANG J H, ZHUO J, GONG L, et al. Relationship between the levels of serum inflammatory factors and neurocytokines and the formation and stability of vertebral artery plaque in elderly patients with posterior circulation cerebral infarction[J]. Journal of Clinical and Experimental Medicine, 2021, 20(10): 1066-1069. https://www.cnki.com.cn/Article/CJFDTOTAL-SYLC202110016.htm
[11]	胡晓菡, 夏艳艳, 陈雨欣. 不同分型脑梗死患者血清炎症细胞因子水平变化及临床意义[J]. 兰州大学学报(医学版), 2021, 47(2): 33-38. https://www.cnki.com.cn/Article/CJFDTOTAL-LZYX202102006.htm HU X H, XIA Y Y, CHEN Y X. Serological levels of cytokines levels in patients of different types of cerebral infarction and its clinical significance[J]. Journal of Lanzhou University (Medical Sciences), 2021, 47(2): 33-38. https://www.cnki.com.cn/Article/CJFDTOTAL-LZYX202102006.htm
[12]	陈琳迪, 何松彬, 吴光勇, 等. β-肌动蛋白对急性脑梗死患者梗死范围的预测价值[J]. 心电与循环, 2021, 40(4): 402-404, 408. https://www.cnki.com.cn/Article/CJFDTOTAL-XDXZ202104014.htm CHEN L D, HE S B, WU G Y, et al. Clinical value of β-actin in predicting infarct size of acute cerebral infarction[J]. Journal of Electrocardiology and Circulation, 2021, 40(4): 402-404, 408. https://www.cnki.com.cn/Article/CJFDTOTAL-XDXZ202104014.htm
[13]	吕英雷, 杜录, 申晓平, 等. 定量脑电图在老年脑梗死患者认知功能评估中的研究[J]. 中华老年心脑血管病杂志, 2021, 23(7): 747-750. https://www.cnki.com.cn/Article/CJFDTOTAL-LNXG202107022.htm LYU Y L, DU L, SHEN X P, et al. Value of quantitative EEG for assessing cognitive function in elderly cerebral infarction patients[J]. Chinese Journal of Geriatric Heart Brain and Vessel Diseases, 2021, 23(7): 747-750. https://www.cnki.com.cn/Article/CJFDTOTAL-LNXG202107022.htm
[14]	戴金明. 定量脑电图在急性脑梗死患者治疗中的作用研究[J]. 重庆医学, 2020, 49(7): 1118-1120. https://www.cnki.com.cn/Article/CJFDTOTAL-CQYX202007021.htm DAI J M. Role of quantitative electroencephalography in the treatment of patients with acute cerebral infarction[J]. Chongqing Medicine, 2020, 49(7): 1118-1120. https://www.cnki.com.cn/Article/CJFDTOTAL-CQYX202007021.htm
[15]	喻蕾, 郝新斌, 葛秋颖. 急性脑梗死患者CXCL12、PTX-3、FⅦa/FⅦAg比值与定量脑电图指标的相关性[J]. 检验医学, 2022, 37(2): 194-195. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYY202202019.htm YU L, HAO X B, GE Q Y. Correlation between CXCL12, PTX-3, FⅦa/FⅦAg and quantitative EEG in patients with acute cerebral infarction[J]. Laboratory Medicine, 2022, 37(2): 194-195. https://www.cnki.com.cn/Article/CJFDTOTAL-SHYY202202019.htm
[16]	金雷雷, 王耀辉, 吕喆, 等. 定量脑电图监测在评估急性脑梗死溶栓效果中的应用[J]. 中华危重病急救医学, 2021, 33(2): 207-210. https://cdmd.cnki.com.cn/Article/CDMD-10092-1021807585.htm JIN L L, WANG Y H, LYU Z, et al. Application of quantitative electroencephalogram monitoring in evaluating thrombolytic effect of acute cerebral infarction[J]. Chinese Critical Care Medicine, 2021, 33(2): 207-210. https://cdmd.cnki.com.cn/Article/CDMD-10092-1021807585.htm
[17]	张哲, 刘大成, 刘婧伊, 等. 急性大面积脑梗死脑电图δ/α功率比值与中线结构移位的相关性研究[J]. 中国卒中杂志, 2020, 15(8): 869-875. https://www.cnki.com.cn/Article/CJFDTOTAL-ZUZH202008011.htm ZHANG Z, LIU D C, LIU J Y, et al. Association of δ/α Ratio of Different Brain Regions with Midline Shift in Patients with Acute Large Hemispheric Infarction[J]. Chinese Journal of Stroke, 2020, 15(8): 869-875. https://www.cnki.com.cn/Article/CJFDTOTAL-ZUZH202008011.htm
[18]	罗林婷, 宋志彬, 王琴, 等. 定量脑电图在监测大脑中动脉重度狭窄侧脑灌注中的应用[J]. 实用医学杂志, 2019, 35(9): 1482-1486, 1491. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYZ201909032.htm LUO L T, SONG Z B, WANG Q, et al. Application of quantitative EEG in monitoring cerebral perfusion of severe stenosis of middle cerebral artery[J]. The Journal of Practical Medicine, 2019, 35(9): 1482-1486, 1491. https://www.cnki.com.cn/Article/CJFDTOTAL-SYYZ201909032.htm
[19]	吕英雷, 杜录, 高星, 等. 定量脑电图检查指标与老年首次脑卒中后认知功能的相关性[J]. 中国神经免疫学和神经病学杂志, 2022, 29(2): 165-168. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSMB202202017.htm LYU Y L, DU L, GAO X, et al. Correlation between quantitative electroencephalogram (EEG) and cognitive function in elderly patients after first stroke[J]. Chinese Journal of Neuroimmunology and Neurology, 2022, 29(2): 165-168. https://www.cnki.com.cn/Article/CJFDTOTAL-ZSMB202202017.htm
[20]	刘秀颖, 蓝瑞芳. 急性缺血性脑卒中定量脑电图特征与CT灌注成像参数的相关性[J]. 上海交通大学学报(医学版), 2021, 41(1): 62-65. https://www.cnki.com.cn/Article/CJFDTOTAL-SHEY202101013.htm LIU X Y, LAN R F. Correlation between quantitative electroencephalogram features and CT perfusion imaging parameters in acute ischemic stroke[J]. Journal of Shanghai Jiaotong University(Medical Science), 2021, 41(1): 62-65. https://www.cnki.com.cn/Article/CJFDTOTAL-SHEY202101013.htm