咽鼓管功能对突发性感音神经性聋患者内镜下鼓室内注射效果的预测价值

王昌阳; 慈军; 管骅

doi:10.16766/j.cnki.issn.1674-4152.003113

咽鼓管功能对突发性感音神经性聋患者内镜下鼓室内注射效果的预测价值

doi: 10.16766/j.cnki.issn.1674-4152.003113

浙江省中西医结合医院耳鼻咽喉科，浙江杭州 310000

基金项目:

浙江省医药卫生科技计划项目 2020KY740

详细信息

通讯作者:
王昌阳，E-mail：lwc791110@126.com

中图分类号: R764.431
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- 文章访问数: 116
- HTML全文浏览量: 52
- PDF下载量: 5
- 被引次数: 0
出版历程
- 收稿日期: 2023-02-08
- 网络出版日期: 2023-09-13

Predictive value of eustachian tube function for endoscopic intra tympanic injection in patients with sudden sensorineural deafness

Department of Otorhinolaryngology, Zhejiang Integrated Traditional Chinese and Western Medicine Hospital, Hangzhou, Zhejiang 310000, China

摘要

摘要: 目的通过检测突发性感音神经性聋患者咽鼓管功能，评估其对内镜下鼓室内注射效果的预测价值。方法选取2021年2月—2022年8月于浙江省中西医结合医院接受内镜下鼓室内注射的突发性感音神经性聋患者115例，根据治疗2周后纯音听阈检测结果分为有效组(听力提高≥15 dB)和无效组(听力提高 < 15 dB)。采用多因素logistic回归分析影响突发性感音神经性聋患者内镜下鼓室内注射效果的相关因素，绘制ROC曲线分析咽鼓管功能对内镜下鼓室内注射效果的预测价值。结果治疗2周后，81例听力较治疗前提高≥15 dB为有效组，其余34例听力提高 < 15 dB为无效组。无效组年龄、受损频率听阈、咽鼓管功能评分水平较有效组高(P < 0.05)；多因素logistic回归分析显示：年龄(OR=1.056，95% CI：1.022~1.155)、受损频率听阈(OR=1.042，95% CI：1.006~1.079)、咽鼓管功能评分(OR=4.412，95% CI：2.247~8.666)为内镜下鼓室内注射效果的影响因素(P < 0.05)。ROC曲线显示，咽鼓管功能评分预测内镜下鼓室内注射效果的AUC为0.812(95% CI：0.728~0.879)，显著高于年龄[0.665(95% CI：0.571~0.750)]、受损频率听阈[0.667(95% CI：0.573~0.752)，P < 0.05]。结论咽鼓管功能对突发性感音神经性聋患者内镜下鼓室内注射效果预测价值相对较高。
- 咽鼓管功能 /
- 突发性感音神经性聋 /
- 内镜治疗 /
- 预测
Abstract: Objective To evaluate the predictive value of the eustachian tube for the effect of endoscopic intra tympanic injection through detecting the function of the eustachian tube in patients with sudden sensorineural deafness. Methods A total of 115 patients with sudden senineural deafness who received endoscopic tympanic injection in Zhejiang Hospital of Integrated Traditional and Western Medicine from February 2021 to August 2022 were selected. According to the pure tone hearing threshold detection results two weeks after treatment, they were divided into effective group (hearing improvement ≥15 dB) and ineffective group (hearing improvement < 15 dB). Multivariate logistic regression was used to analyze the related factors affecting the effect of endoscopic tympanic injection in patients with sudden senineural deafness, and ROC curve was drawn to analyze the predictive value of eustachian tube function on the effect of endoscopic tympanic injection. Results After 2 weeks of treatment, 81 cases of hearing improvement ≥15 dB compared with before treatment were effective group, and the remaining 34 cases of hearing improvement < 15 dB were ineffective group. The age, impaired frequency threshold and eustachian tube function score of ineffective group were higher than those of effective group (P < 0.05). Multivariate logistic regression analysis showed that: Age (OR=1.056, 95% CI: 1.022-1.155), impaired frequency threshold (OR=1.042, 95% CI: 1.006-1.079), eustachian tube function score (OR=4.412, 95% CI: 2.247-8.666) were the risk factors for endoscopic tympanic injection effect (P < 0.05). ROC curve showed that the prediction AUC of endoscopic tympanic injection effect was 0.812 (95% CI: 0.728-0.879), which was significantly higher than that of age (0.665, 95% CI: 0.571-0.750) and impaired frequency hearing threshold (0.667, 95% CI: 0.573-0.752), P < 0.05. Conclusion The function of eustachian tube is relatively valuable in predicting the effect of endoscopic tympanic injection in patients with sudden senineural deafness.
- Eustachian tube function /
- Sudden sensorineural deafness /
- Endoscopic therapy /
- Prediction

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图 1 内镜下鼓室内注射效果的预测因素ROC曲线

Figure 1. ROC curve of predictive factors for endoscopic intra tympanic injection effect

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表 1 内镜下鼓室内注射效果单因素分析

Table 1. Single factor analysis of endoscopic intra tympanic injection effect

项目	无效组(n=34)	有效组(n=81)	统计量	P值
年龄(x±s，岁)	53.07±9.72	46.36±9.66	3.384^a	0.001
性别(男性/女性，例)	20/14	53/28	0.451^b	0.502
体重指数(x±s)	23.56±1.54	23.61±1.49	0.160^a	0.873
吸烟史[例(%)]	23(67.65)	52(64.20)	0.126^b	0.723
高血压[例(%)]			0.538^b	0.463
有	12(35.29)	23(28.40)
无	22(64.71)	58(71.60)
眩晕[例(%)]			0.714^b	0.398
有	11(32.35)	20(24.69)
无	23(67.65)	61(75.31)
耳鸣[例(%)]			0.241^b	0.624
有	9(26.47)	18(22.22)
无	25(73.53)	63(77.78)
发病侧别[例(%)]			0.016^b	0.899
左侧	21(61.76)	49(60.49)
右侧	13(38.24)	32(39.51)
听力类型[例(%)]			0.061^b	0.805
低频/平坦型	21(61.76)	52(64.20)
高频/全聋型	13(38.24)	29(35.80)
受损频率听阈(x±s，dB)	63.58±12.73	54.65±16.39	3.141^a	0.002
咽鼓管功能评分(x±s，分)	5.48±1.10	4.15±1.00	6.075^a	<0.001
注：^a为t值，^b为χ²值。

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表 2 内镜下鼓室内注射效果多因素logistic分析

Table 2. Logistic analysis of the effect of intratympanic injection under endoscope

变量	B	SE	Wald χ²	P值	OR值	95% CI
年龄	0.083	0.031	7.046	0.008	1.086	1.022~1.155
受损频率听阈	0.041	0.018	5.147	0.023	1.042	1.006~1.079
咽鼓管功能评分	1.484	0.344	18.580	<0.001	4.412	2.247~8.666

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表 3 内镜下鼓室内注射效果的预测效能

Table 3. Predictive efficacy of endoscopic intra tympanic injection

变量	SE	AUC	95% CI	特异度(%)	敏感度(%)	截断值
年龄	0.054	0.665	0.571~0.750	55.65	76.47	46.84
受损频率听阈	0.053	0.667	0.573~0.752	50.62	79.41	53.03
咽鼓管功能评分	0.040	0.812	0.728~0.879	66.67	85.29	4.24

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