益气活血法在脑小血管病认知障碍患者中的临床应用

陈克龙; 宋成城; 陈凌

doi:10.16766/j.cnki.issn.1674-4152.003220

益气活血法在脑小血管病认知障碍患者中的临床应用

doi: 10.16766/j.cnki.issn.1674-4152.003220

浙江中医药大学附属温州市中医院神经内科，浙江温州 325000

基金项目:

浙江省中医药科技计划项目 2022ZB338

温州市基础性科研项目 Y20220219

详细信息

通讯作者:
陈克龙，E-mail: 247360354@qq.com

中图分类号: R743 R242
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- 文章访问数: 116
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- 被引次数: 0
出版历程
- 收稿日期: 2023-06-28
- 网络出版日期: 2023-11-23

Clinical application of supplementing Qi and activating blood in patients with cognitive impairment due to cerebral small vessel disease

Department of Neurology, Wenzhou TCM Hospital of Zhejiang Chinese Medical University, Wenzhou, Zhejiang 325000, China

摘要

摘要: 目的探究利用补阳还五汤进行益气活血法治疗脑小血管病认知障碍患者的临床疗效，观察患者认知功能、注意力、执行能力和炎性因子水平的变化。方法选取2022年2月—2023年5月浙江中医药大学附属温州市中医院收治的脑小血管病认知障碍患者60例，采用随机数表法分为2组，对照组(30例)给予多奈哌齐片治疗，观察组(30例)在对照组治疗方案的基础上给予补阳还五汤进行益气活血法治疗。通过蒙特利尔认知评估量表(MoCA)、数字符号转换测验量表(DSST)和连线测验(TMT)评价患者的认知功能、注意力和执行功能，比较2组患者炎性因子水平[血同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)]。结果与治疗前比较，治疗后2组患者MoCA、DSST评分显著升高(均P＜0.05)，且观察组的MoCA、DSST评分显著高于对照组(均P＜0.05)；与治疗前比较，治疗后2组患者TMT耗时显著下降(均P＜0.05)，且观察组的TMT耗时[TMT-A：(71.10±10.44)s；TMT-B：(222.63±30.84)s]显著低于对照组[TMT-A：(77.63±12.44)s；TMT-B：(241.53±38.03)s, 均P＜0.05]；与治疗前比较，治疗后2组患者Hcy和hs-CRP水平显著降低(均P＜0.05)，且观察组Hcy和hs-CRP显著低于对照组(均P＜0.05)。结论益气活血法可显著提高脑小血管病认知障碍患者的认知功能、注意力和执行功能，并降低患者的炎性因子水平。
- 益气活血法 /
- 脑小血管病 /
- 认知功能障碍
Abstract: Objective The purpose of this study was to investigate the clinical effect of qi-supplementation and blood-activation therapy with Buyang Huanwu Decoction in the treatment of patients with cognitive impairment due to cerebral small vessel disease, focusing on the effects on cognitive function, attention, executive function and inflammatory factors. Methods A total of 60 patients with cerebral small vessel disease and cognitive impairment admitted to Wenzhou TCM Hospital of Zhejiang Chinese Medical University from February 2022 to May 2023 were selected. The random number table method was used in two groups. The control group (30 cases) was treated with donepezil tablets, and the observation group (30 cases) was treated with Buyang Huanwu decoction for qi-supplementation and blood-activation on the basis of the treatment scheme of the control group. The patients ' cognitive function, attention and executive function were assessed by using Montreal cognitive assessment scale (MoCA), the digit symbol substitution test (DSST) and the trail making test (TMT). Levels of inflammatory factors [blood homocysteine (Hcy), hypersensitive C-reactive protein (hs-CRP)] were compared between the two groups. Results Compared before treatment, the MoCA and DSST scores in both groups were significantly increased after treatment (all P < 0.05), and the MoCA and DSST scores in the observation group were significantly higher than those in the control group (all P < 0.05). Compared with before treatment, the TMT time in both groups decreased significantly after treatment (all P < 0.05), and the TMT time in the observation group [TMT-A: (71.10±10.44) s; TMT-B: (222.63±30.84) s] was significantly lower than that in the control group [TMT-A: (77.63±12.44) s; TMT-B: (241.53±38.03) s, all P < 0.05]. After treatment, the levels of Hcy and hs-CRP in both groups were significantly lower than those before treatment (all P < 0.05), and Hcy and hs-CRP in the observation group were significantly lower than those in the control group (all P < 0.05). Conclusion Supplemening Qi and activating blood circulation can significantly improve the cognitive function and executive function of patients with cognitive impairment due to cerebral small vessel disease, and reduce the level of inflammatory factors in patients.
- Supplementing Qi and activating blood /
- Cerebral small vessel disease /
- Cognitive dysfunction

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表 1 2组CSVD-VCI患者治疗前后MoCA评分比较(x±s，分)

Table 1. Comparison of MoCA scores before and after treatment in 2 groups of CSVD-VCI patients (x±s, points)

组别	例数	治疗前	治疗后	t值	P值
观察组	30	21.13±2.06	26.37±2.17	14.012	< 0.001
对照组	30	21.53±2.08	24.63±2.71	12.143	< 0.001
t值		0.748	2.733
P值		0.458	0.008

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表 2 2组CSVD-VCI患者治疗前后DSST评分比较(x±s，分)

Table 2. Comparison of DSST scores before and after treatment in two groups of CSVD-VCI patients (x±s, points)

组别	例数	治疗前	治疗后	t值	P值
观察组	30	5.43±1.36	8.86±1.05	7.293	< 0.001
对照组	30	5.52±1.17	7.03±1.43	5.126	< 0.001
t值		0.275	5.649
P值		0.785	＜0.001

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表 3 2组CSVD-VCI患者治疗前后TMT耗时比较(x±s，s)

Table 3. Comparison of TMT time before and after treatment in two groups of CSVD-VCI patients (x±s, s)

组别	例数	TMT-A		TMT-B
组别	例数	治疗前	治疗后	治疗前	治疗后
观察组	30	83.40±12.97	71.10±10.44^a	260.67±36.87	222.63±30.84^a
对照组	30	84.77±12.45	77.63±12.44^a	262.13±38.47	241.53±38.03^a
t值		0.416	2.204	0.151	2.114
P值		0.679	0.032	0.881	0.039
注：与同组治疗前比较，^aP < 0.05。

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表 4 2组CSVD-VCI患者治疗前后Hcy及hs-CRP比较(x±s)

Table 4. Comparison of Hcy and hs-CRP before and after treatment in two groups of CSVD-VCI patients (x±s)

组别	例数	Hcy(μmol/L)		t值	P值	hs-CRP(mg/L)		t值	P值
组别	例数	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值
观察组	30	17.32±2.42	8.34±3.19	8.271	< 0.001	11.32±1.96	4.28±1.94	9.184	< 0.001
对照组	30	17.63±3.85	14.38±2.28	4.381	< 0.001	11.43±1.84	8.92±1.22	4.024	< 0.001
t值		0.373	8.437			0.224	11.089
P值		0.710	＜0.001			0.823	＜0.001

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