非编码RNA在宫腔粘连中的研究进展

王激雯; 陈醒; 戴辉华

doi:10.16766/j.cnki.issn.1674-4152.003519

非编码RNA在宫腔粘连中的研究进展

doi: 10.16766/j.cnki.issn.1674-4152.003519

1.
南京医科大学第一临床医学院妇产科，江苏南京 210029
2.
江苏省人民医院南京医科大学第一附属医院妇科，江苏南京 210029

基金项目:

江苏省妇幼健康科研项目 F201921

南京医科大学第一附属医院国家自然科学基金青年基金培育计划 PY2021003

详细信息

通讯作者:
戴辉华，E-mail：daihuihua65@163.com

中图分类号: R711.74
计量
- 文章访问数: 36
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- 被引次数: 0
出版历程
- 收稿日期: 2023-08-21
- 网络出版日期: 2024-07-20

Research progress of non-coding RNAs in intrauterine adhesion

1.
Department of Obstetrics and Gynecology, the First Medical College of Nanjing Medical University, Nanjing, Jiangsu 210029, China

摘要

摘要: 宫腔粘连(intrauterine adhesion，IUA)，又称Asherman综合征，是育龄期女性较为常见的生殖系统疾病，其通常继发于产后感染、宫腔操作及生殖器结核等。IUA是一种由组织损伤引起的纤维化疾病，当子宫内膜基底层受到损害致修复障碍，细胞外基质过度沉积和重组，纤维结缔组织增生并取代正常的子宫内膜，导致子宫腔、宫颈管部分或完全粘连，从而引起一系列临床症状，包括周期性下腹痛、月经异常、生育能力降低等，严重危害女性的身心健康。目前主要的治疗手段是宫腔镜下粘连分解术，但术后往往存在高复发率及不孕等问题，IUA的治疗仍为临床一大难题。非编码RNA(non-coding RNA，ncRNA)是一类缺乏编码蛋白质潜能的RNA，是参与基因表达调控的重要因子，并在生物体的正常代谢活动及疾病的发生发展过程中发挥着重要作用。近年来的研究表明，TGF-β1/Smad、Wnt/β-catenin和NF-κB等信号通路与IUA的发生、发展关系密切，ncRNA可能通过影响这些通路的关键因子来参与子宫内膜纤维化的调控。ncRNA主要包括微小RNA、长链非编码RNA和环状RNA，这些ncRNA有望成为宫腔粘连疾病潜在的诊断标志物及治疗靶点。本文综述了ncRNA在IUA中的研究进展，以期对IUA的防治提供新思路，提高患者的生活质量。
- 宫腔粘连 /
- 非编码RNA /
- 微小RNA /
- 长链非编码RNA /
- 环状RNA /
- 诊断 /
- 治疗
Abstract: Intrauterine adhesion (IUA), also known as Asherman' s syndrome, is a common reproductive system disorder in women of reproductive age, often occurring as a result of postpartum infection, uterine surgery, or genital tuberculosis. IUA is a fibrotic disease caused by tissue damage. When the trauma to the endometrial basement membrane leads to repair disorder, excessive deposition and reorganization of extracellular matrix and proliferation of fibrous connective tissue replace the normal endometrium. This can ultimately cause partial or complete obstruction of uterine cavity or cervical canal, which may lead to various complications, including cyclical pelvic pain, menstrual disturbance, and disminished fertility, seriously affecting the physical and mental health of women. Transcervical resection of adhesion is the current method for IUA treatment, but the high recurrence rate of postoperative adhesion and subsequent infertility make the treatment of IUA still a significant challenge. Non-coding RNAs (ncRNAs), a class of RNA molecules that lack protein-coding capacity, are integral to the regulation of gene expression and are significant contributors to the metabolic life activity of organisms and the development of diseases. Recent studies have identified associations between TGF-β1/Smad, Wnt/β-catenin, and NF-κB signaling pathways and the development of IUA. ncRNAs potentially modulate endometrial fibrogenesis by targeting key components within these pathways. ncRNAs mainly include microRNA (miRNA), long non-coding RNA (lncRNA), and circular RNA (circRNA), which are expected to be therapeutic targets and diagnostic markers for IUA. This review summarizes the progress of research on ncRNAs and IUA, to offer novel insights for the prevention and treatment of IUA, ultimately enhancing patients' quality of life.
- Intrauterine adhesion /
- Non-coding RNA /
- MicroRNA /
- Long non-coding RNA /
- Circular RNA /
- Diagnosis /
- Treatment

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参考文献(39)

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