Normal values of T1, T2, and ECV in 1.5T cardiovascular magnetic resonance scanning in health adults
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摘要:
目的 本研究旨在勾画正常成人心肌,分析T1、T2及细胞外间质容积分数(ECV)的范围,并建立适用于新疆地区的心血管磁共振成像(CMR)参数定量技术参考值。 方法 收集并分析2023年3—9月在新疆医科大学第一附属医院接受CMR检查的122名健康成人。采用Cvi软件进行心肌勾画,分析心功能参数、T1、T2及ECV值在不同性别、年龄及民族之间的差异。 结果 整体心肌的T1平均值为(1 090±74)ms,T2平均值为(53.0±1.7)ms,ECV平均值为(28.3±3.3)%。女性T1值[(1 121±78)ms vs.(1 065±61)ms, P<0.05]、T2值[(53.3±1.4)ms vs. (52.7±1.9)ms, P<0.05]和ECV值[(29.1±2.9)% vs. (27.7±3.5)%, P<0.001]高于男性。随着年龄的增长,T1和ECV值也增高,但差异无统计学意义,基底段T2值在不同年龄组间差异有统计学意义,整体人群的T1和T2值与年龄存在相关性,T2值的年龄与性别为男性有相关性,T1和ECV值与年龄无相关性。在民族差异性分析中,少数民族的T1值明显高于汉族,但T2和ECV值在组间比较中差异无统计学意义。 结论 在本研究中,健康成人心肌的T1、T2及ECV值在年龄、性别及民族中差异有统计学意义。使用CMR参数定量技术时,有必要对年龄、性别及民族进行校正,有助于临床医师根据本地区参考值更加准确地诊断心脏疾病,确定疾病进展。 -
关键词:
- 心脏磁共振成像 /
- 纵向弛豫时间定量成像 /
- 横向弛豫时间定量成像 /
- 细胞外间质容积分数 /
- 正常参考值
Abstract:Objective This study aims to describe normal adult myocardium, analyze the range of T1, T2, and ECV, and establish a quantitative technical reference value of cardiovascular magnetic resonance (CMR) parameters suitable for Xinjiang. Methods A total of 122 healthy adults who underwent CMR examination in the First Affiliated Hospital of Xinjiang Medical University from March to September 2023 were collected and analyzed. The myocardial was performed using Cvi software, and the differences in cardiac function parameters, T1, T2, and ECV values among different genders, ages, and nationalities were analyzed. Results The average value of T1, T2, and ECV of the whole myocardium was (1 090±74) ms, (53.0±1.7) ms, and (28.3±3.3)%, respectively. The values of T1, T2, and ECV in females were higher than those in males: T1 [(1 121±78) ms vs. (1 065±61) ms, P < 0.05], T2 [(53.3±1.4) ms vs. (52.7±1.9) ms, P < 0.05], and ECV [(29.1±2.9)% vs. (27.7±3.5)%, P < 0.001]. The values of T1 and ECV increased with age, but there was no statistical difference. The T2 values of myocardium basal segment showed statistically significant differences between different age groups, and there was a correlation between T1 and T2 values and age in the whole population. The age correlation of T2 values was shown only in the male population, and the age correlation of T1 and ECV values was independent of gender. In the analysis of ethnic variability, ethnic minorities had significantly higher T1 values than Han Chinese, but the between-group differences in T2 and ECV values were not statistically significant. Conclusion In this study, the values of T1, T2, and ECV in the myocardium of health adult vary with age, gender, and ethnicity. It is necessary to correct the age, gender, and ethnicity when using quantitative techniques for CMR parameters to help clinicians diagnose cardiac disease more accurately and determine disease progress based on local reference values. -
表 1 研究人群的一般基线资料及心功能参数比较
Table 1. Comparison of general baseline data and cardiac function parameters in the study population
项目 合计(n=122) 男性(n=68) 女性(n=54) 统计量 P值 年龄[M(P25, P75),岁] 58.0(50.8, 64.0) 55.5(45.5, 62.0) 60.0(53.5, 70.0) 3.086a 0.003 身高[M(P25, P75),m] 1.7(1.6, 1.8) 1.70(1.70, 1.80) 1.62(1.60, 1.64) -8.855a 0.001 体重[M(P25, P75),kg] 72.5(65.0, 77.8) 75.0(70.0, 85.0) 65.0(64.3, 70.5) -5.639a 0.001 BMI[M(P25, P75)] 25.4(23.9, 27.0) 25.4(24.2, 27.1) 25.6(23.6, 27.1) -0.670a 0.503 BSA[M(P25, P75),m2] 1.8(1.7, 2.0) 1.9(1.8, 2.0) 1.7(1.7, 1.8) -6.578a 0.001 少数民族[例(%)] 27(22.13) 15(22.05) 12(22.22) 0.001b 0.983 HR[M(P25, P75),次/min] 66(61, 73) 66(60, 74) 66(61, 72) -0.168a 0.867 LVEDV/BSA[M(P25, P75),mL/m2] 61.7(53.9, 69.5) 57.7(52.5, 67.1) 65.3(58.1, 73.7) -1.365a 0.175 LVESV/BSA[M(P25, P75),mL/m2] 25.1(20.5, 31.0) 21.5(17.9, 27.8) 28.4(22.8, 33.1) -1.046a 0.298 LVEF[M(P25, P75),%] 60.2(55.0, 64.3) 63.0(59.1, 66.9) 57.9(54.2, 62.7) 2.422a 0.001 左室舒张期质量指数[M(P25, P75),g/m2] 42.3(37.0, 48.5) 46.3(40.5, 51.5) 38.0(33.2, 42.6) -5.247a 0.001 左室收缩期质量指数[M(P25, P75),g/m2] 47.7(40.8, 43.7) 50.6(46.3, 56.6) 41.6(37.0, 47.1) -5.551a 0.001 注:a为Z值,b为χ2值。BMI为体重指数;BSA为体表面积;HR为心率;LVEDV/BSA为左室舒张末期容积指数;LVESV/BSA为左室收缩期末容积指数;LVEF为左室射血分数。 表 2 研究人群的CMR定量参数在性别间比较(x ± s)
Table 2. The quantitative parameters of CMR in the study population were compared between genders(x ± s)
项目 类别 总体人群 男性(n=68) 女性(n=54) t值 P值 T1(ms) 基底段 1 114±79 1 080±68 1 156±77 -5.933 0.001 中间段 1 072±55 1 051±48 1 097±53 -4.520 0.001 心尖段 1 084±80 1 063±65 1 111±88 -3.314 0.001 整体 1 090±74 1 065±61 1 121±78 -7.643 0.001 T2(ms) 基底段 52.5±1.9 52.2±2.2 52.9±1.4 -2.218 0.028 中间段 52.5±1.6 52.3±1.8 52.9±1.2 -2.197 0.030 心尖段 53.8±1.4 53.7±1.4 54.0±1.3 -0.974 0.332 整体 53.0±1.7 52.7±1.9 53.3±1.4 -2.982 0.003 ECV(%) 基底段 27.8±2.5 27.2±2.0 28.6±3.0 0.989 0.005 中间段 28.2±2.6 27.5±2.0 29.1±3.0 0.231 0.001 心尖段 29.0±4.4 28.4±5.4 29.7±2.6 1.453 0.073 整体 28.3±3.3 27.7±3.5 29.1±2.9 1.511 0.001 表 3 研究人群的CMR定量参数在不同年龄组间比较
Table 3. The quantitative parameters of CMR in the study population were compared between different age groups
项目 ≤55岁(n=49) >55岁(n=73) 统计量 P值 年龄[M(P25, P75),岁] 48.0(38.5, 51.5) 62.0(59.0, 70.0) -9.347a 0.001 性别(男/女,例) 34/15 34/39 5.148b 0.023 BMI[M(P25, P75)] 25.9(24.1,27.5) 25.4(23.7, 26.6) -0.569a 0.569 BSA[M(P25, P75),m2] 1.88(1.77, 2.01) 1.79(1.71, 1.90) -2.466a 0.014 HR[M(P25, P75),次/min] 68(62, 75) 65(60, 71) -1.490a 0.136 LVEDV/BSA[M(P25, P75),mL/m2] 65.4(56.7, 74.1) 60.5(52.8, 67.6) -2.243a 0.025 LVESV/BSA[M(P25, P75),mL/m2] 27.2(23.1, 31.9) 22.6(19.1, 29.7) -2.462a 0.014 LVEF[M(P25, P75),%] 59.7(54.3, 64.0) 61.0(55.4, 65.5) -1.199a 0.231 左室舒张期质量指数[M(P25, P75),g/m2] 45.8(38.7, 50.7) 40.3(36.1, 46.1) -2.509a 0.012 左室收缩期质量指数[M(P25, P75),g/m2] 49.4(44.2, 55.3) 45.3(39.4, 51.7) -2.259a 0.024 T1(x ± s,ms) 基底段 1 099±68 1 124±86 -2.259a 0.024 中间段 1 071±58 1 073±54 -0.462a 0.644 心尖段 1 071±76 1 093±81 -1.648a 0.099 整体 1 080±68 1 097±77 -2.038a 0.042 T2(x ± s,ms) 基底段 52.1±1.7 52.8±2.0 -2.645a 0.008 中间段 52.5±1.6 52.5±1.6 -0.574a 0.566 心尖段 53.9±1.0 53.8±1.6 -0.159a 0.873 整体 52.8±1.6 53.1±1.8 -1.492a 0.136 ECV(x ± s,%) 基底段 28.0±2.7 27.7±2.4 -0.467a 0.640 中间段 28.2±2.7 28.2±2.7 -0.264a 0.792 心尖段 28.4±4.8 29.3±4.2 -1.078a 0.281 整体 28.2±3.4 28.4±3.3 -0.356a 0.722 注:a为Z值,b为χ2值。 表 4 研究人群的CMR定量参数在不同民族间比较
Table 4. The quantitative parameters of CMR in the study population were compared among different nationalities
项目 少数民族(n=27) 汉族(n=27) 统计量 P值 年龄[M(P25, P75), 岁] 51.0(37.0, 60.0) 51.0(43.0, 60.0) -0.312a 0.755 性别(男/女,例) 15/12 16/11 0.076b 0.783 BMI[M(P25, P75)] 26.0(24.5,28.3) 26.0(24.7, 27.2) -0.502a 0.616 BSA[M(P25, P75),m2] 1.9(1.8, 2.2) 1.9(1.8, 2.0) -0.762a 0.446 HR[M(P25, P75),次/min] 69(59, 77) 68(61, 71) -0.286a 0.775 LVEDV/BSA[M(P25, P75),mL/m2] 67.1(57.9, 79.5) 65.4(58.5, 73.1) -0.562a 0.574 LVESV/BSA[M(P25, P75),mL/m2] 29.6(23.7, 33.2) 25.4(21.5, 31.0) -1.047a 0.295 LVEF[M(P25, P75), %] 60.1(55.0, 63.9) 60.6(54.6, 67.4) -1.055a 0.291 左室舒张期质量指数[M(P25, P75), g/m2] 43.2(38.4, 49.3) 45.9(37.0, 52.4) -0.268a 0.789 左室收缩期质量指数[M(P25, P75), g/m2] 49.4(43.6, 55.8) 46.6(42.1, 55.6) -0.666a 0.505 T1(x ± s, ms) 基底段 1 113±49 1 112±104 -0.753a 0.452 中间段 1 092±50 1 060±55 -2.292a 0.022 心尖段 1 087±68 1 067±77 -1.064a 0.287 整体 1 098±57 1 081±84 -2.280a 0.023 T2(x ± s, ms) 基底段 52.3±1.9 52.6±1.7 -0.493a 0.622 中间段 52.6±1.4 52.5±1.8 -0.061a 0.952 心尖段 54.2±1.2 54.2±1.0 -0.026a 0.979 整体 53.0±1.7 53.1±1.7 -0.333a 0.739 ECV(x ± s, %) 基底段 28.6±3.2 27.4±2.4 -1.306a 0.192 中间段 28.3±2.8 28.3±2.4 -0.182a 0.856 心尖段 28.9±3.7 28.3±5.1 -0.510a 0.610 整体 28.6±3.2 28.0±3.5 -1.092a 0.275 注:a为Z值,b为χ2值。 表 5 观察者间和观察者内一致性分析
Table 5. Inter-observer and intra-observer consistency analysis
参数 观察者间 观察者内 ICC 95% CI P值 ICC 95% CI P值 T1(ms) 0.892 0.869~0.911 <0.001 0.905 0.885~0.922 <0.001 T2(ms) 0.953 0.942~0.961 <0.001 0.941 0.921~0.952 <0.001 ECV(%) 0.920 0.903~0.934 <0.001 0.903 0.882~0.920 <0.001 -
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