振幅整合脑电图在新生儿脑功能监测中的应用研究进展

李先红; 张健

doi:10.16766/j.cnki.issn.1674-4152.003603

振幅整合脑电图在新生儿脑功能监测中的应用研究进展

doi: 10.16766/j.cnki.issn.1674-4152.003603

李先红,
张健^,

安徽省儿童医院新生儿科，安徽合肥 230051

基金项目:

安徽省卫生健康科研项目 AHWJ2022b087

详细信息

通讯作者:
张健，E-mail: zjnetmail@126.com

中图分类号: R722 R651.15 R741.044
计量
- 文章访问数: 19
- HTML全文浏览量: 12
- PDF下载量: 3
- 被引次数: 0
出版历程
- 收稿日期: 2023-10-10
- 网络出版日期: 2024-09-05

Research progress of amplitude-integrated electroencephalography in neonatal brain function monitoring

LI Xianhong,
ZHANG Jian^,

Department of Neonatology, Anhui Provincial Children's Hospital, Hefei, Anhui 230051, China

摘要

摘要: 新生儿脑损伤是新生儿期常见的神经系统疾病，通常与围生期窒息、缺氧缺血、高胆红素血症、早产及感染等诸多因素有关，可能导致早期的神经行为异常及远期各种不同程度的神经发育障碍。因此，早期及时准确的识别新生儿脑损伤、早期干预，是预防其不良神经发育结局的关键。脑电监测是新生儿脑病诊断、评估和预后预测的重要工具。近年来，振幅整合脑电图(amplitude-integrated electroencephalography, aEEG)作为一项无创的脑功能监测工具，开始逐渐应用于新生儿重症监护病房。相较传统的脑电图，aEEG的信号处理更为简化，主要关注频谱中的低频波形，其输出结果通常显示为脑电图的连续走势图，易于临床医生进行观察和分析。目前aEEG已广泛应用于新生儿窒息、缺氧缺血性脑病、新生儿高胆红素血症、新生儿惊厥以及新生儿感染等引起的新生儿脑损伤早期的脑功能监测。aEEG可以在新生儿出生后的几小时内开始监测，可及时发现异常脑电活动，在新生儿脑损伤的早期诊断、评估和预后预测中具有较高的灵敏度和特异度。随着aEEG在新生儿临床的深入研究，未来通过不断改进aEEG技术、建立aEEG监测的标准化流程以及联合其他脑结构或脑功能检查工具，将更加有效提高新生儿脑损伤的诊断和预后预测价值，以便早期发现脑损伤和脑发育异常，进而早期干预，改善预后。
- 振幅整合脑电图 /
- 婴儿，新生 /
- 脑损伤 /
- 监测
Abstract: Neonatal brain injury is a common neurological disorder in the newborn period, often associated with various factors such as perinatal asphyxia, hypoxic-ischemic events, hyperbilirubinemia, prematurity, and infections. The prognosis can range from early neurobehavioral abnormalities to various degrees of long-term neurodevelopmental disorders. Therefore, early and accurate identification of neonatal brain injury and timely intervention are crucial in preventing adverse neurodevelopmental outcomes. Brainwave monitoring is an important tool for diagnosing, evaluating, and predicting the prognosis of neonatal brain diseases. In recent years, amplitude-integrated electroencephalography (aEEG) as a non-invasive brain function monitoring tool has gradually been used in neonatal intensive care units. Compared to traditional electroencephalography, aEEG signal processing is simplified, focusing mainly on low-frequency waveforms in the spectrum. Its output typically displays as a continuous trend graph, making it easy for clinicians to observe and analyze. Therefore, aEEG is currently widely used for early brain function monitoring in neonatal brain injuries caused by birth asphyxia, hypoxic-ischemic encephalopathy, neonatal hyperbilirubinemia, neonatal seizures, and neonatal infections. Since aEEG can be initiated within a few hours after birth, it can promptly detect abnormal brainwave activity, demonstrating high sensitivity and specificity in the early diagnosis, evaluation, and prognosis prediction of neonatal brain injuries. With further research into aEEG in neonatal clinical settings, continuous improvement of aEEG technology, establishment of standardized aEEG monitoring procedures, and the integration of other brain structure or function assessment tools, will effectively enhance the diagnostic and prognostic value of neonatal brain injuries, enabling early detection of brain injuries and developmental abnormalities, and thereby improving outcomes through early intervention.
- Amplitude-integrated electroencephalography /
- Infant, newborn /
- Brain injury /
- Monitoring

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参考文献(32)

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