HIV阳性原发骨骼肌外周T细胞淋巴瘤非特指型并发横纹肌溶解1例及文献复习

马梦雪; 乔淑凯

doi:10.16766/j.cnki.issn.1674-4152.003655

HIV阳性原发骨骼肌外周T细胞淋巴瘤非特指型并发横纹肌溶解1例及文献复习

doi: 10.16766/j.cnki.issn.1674-4152.003655

马梦雪,
乔淑凯^,

河北医科大学第二医院血液内科，河北石家庄 050000

详细信息

通讯作者:
乔淑凯，E-mail：qiaoshukai@hebmu.edu.cn

中图分类号: R733.1 R512.91
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出版历程
- 收稿日期: 2024-01-25
- 网络出版日期: 2024-11-19

HIV positive primary skeletal muscle Peripheral T Cell lymphoma, not otherwise specified with complex rhabdomyolysis: A case report and literature review

MA Mengxue,
QIAO Shukai^,

Department of Hematology, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China

摘要

摘要: PTCL-NOS是NHL中的一种异质性强、侵袭性高的亚型，多起病于淋巴结，少部分病灶原发于结节外，结节外侵犯的部位多见于肝、脾、骨髓，软组织侵犯较为罕见，尤以骨骼肌浸润鲜见报道。本研究报道1例HIV阳性的原发骨骼肌PTCL-NOS的诊治过程并进行文献复习，以提高临床医师对此类疾病的认识。
- 外周T细胞淋巴瘤非特指型 /
- 骨骼肌 /
- 艾滋病 /
- 横纹肌溶解症
Abstract: Peripheral T cell lymphoma, not otherwise specified (PTCL-NOS) is a highly heterogeneous and invasive subtype of non-Hodgkin ' s lymphoma (NHL), which often occurs in lymph nodes, with a small number of lesions originating from the outside of the node. Extranodal invasion is more common in the liver, spleen, and bone marrow, and soft tissue invasion is rare, especially in skeletal muscle infiltration, which is rarely reported. This study reports on the diagnosis and treatment process of one HIV-positive primary skeletal muscle PTCL-NOS case and conducts a literature review to enhance clinical physicians ' understanding of this disease.
- Peripheral T cell lymphoma, not otherwise specified /
- Skeletal muscle /
- Acquired immunodeficiency syndrome /
- Rhabdomyolysis

HTML全文

图 1 全身PET/CT显示多部位骨骼肌弥漫性高代谢

注：A为头颈部横断面；B为纵隔横断面；C为腹部及双上肢横断面；D为盆腔横断面；E为下肢(大腿)横断面；F为下肢(小腿)横断面；G为髂血管走行区淋巴结病灶；H为腋窝淋巴结病灶；I为右侧膈肌脚病灶融合图；J为左腹股沟淋巴结病灶；K为左前部膈肌淋巴结病灶；L为最大密度投影图。

Figure 1. Whole-body PET/CT showed diffuse hypermetabolism of skeletal muscle at multiple sites

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图 2 左肱二头肌活检病理(×200)

注: A可见弥漫一致的异型淋巴样细胞浸润；B为免疫组化染色CD3阳性表达；C为免疫组化染色CD20阴性表达。

Figure 2. Biopsy pathology of the left biceps (×200)

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表 1 患者血生化检查结果

Table 1. Blood biochemistry results of patient

时间	MYO(ng/mL)	CK(U/L)	LDH(U/L)	Cr(μmmol/L)
2023年7月8日	4 670	3 135	3 878	47
2023年7月20日	5 685	8 796	6 574	114
2023年7月21日	5 437	9 599	10 714	146
2023年7月25日	5 011	1 927	3 133	137
2023年7月27日	3 194	844	3 064	141

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