外周血IL-17A水平与寻常痤疮的相关性研究及对痤疮瘢痕的预测价值

方静; 王莉文; 王静; 甘智慧; 王娟

doi:10.16766/j.cnki.issn.1674-4152.003664

外周血IL-17A水平与寻常痤疮的相关性研究及对痤疮瘢痕的预测价值

doi: 10.16766/j.cnki.issn.1674-4152.003664

方静¹,
王莉文¹,
王静¹,
甘智慧¹,
王娟^{1, 2, ,}

1.
蚌埠医科大学研究生院，安徽蚌埠 233030
2.
中国科学技术大学附属第一医院(安徽省立医院)皮肤科，安徽合肥 230001

基金项目:

中央高校基本科研业务专项基金 WK9110000114

详细信息

通讯作者:
王娟，E-mail: wangjuan_8282@mail.ustc.edu.cn

中图分类号: R758.733
计量
- 文章访问数: 21
- HTML全文浏览量: 17
- PDF下载量: 3
- 被引次数: 0
出版历程
- 收稿日期: 2024-01-15

Relationship between peripheral blood IL-17A levels and severity of acne vulgaris and its predictive value for acute acne scars

1.
Graduate School of Bengbu Medical University, Bengbu, Anhui 233030, China

摘要

摘要: 目的目前寻常痤疮的发病机制仍在持续的探究中，国外有研究表明痤疮发病与血清中白细胞介素17水平密切相关，本研究旨在探讨外周血IL-17A水平与痤疮严重程度的相关性及对痤疮瘢痕的预测价值。方法纳入2022年10月—2023年10月在安徽省立医院皮肤科治疗的130例寻常痤疮患者作为观察组，根据痤疮综合分级系统将痤疮组分为轻中度组(45例)、重度组(40例)、极重度组(45例)，选取40名健康体检者作为对照组。再根据瘢痕严重程度将观察组分为无瘢痕组(25例)、轻度瘢痕组(25例)、中度瘢痕组(40例)及重度瘢痕组(40例)。采用酶联免疫吸附法检测外周血IL-17A水平。结果轻中度组、重度组、极重度组寻常痤疮患者外周血中白细胞介素17A均显著高于健康对照组(P＜0.05)，痤疮严重程度与外周血IL-17A水平呈正相关关系(r=0.724，P＜0.001)；轻度、中度、重度痤疮瘢痕组患者外周血中IL-17A水平逐渐升高，显著高于无瘢痕组(P＜0.05)。Spearman分析显示，痤疮瘢痕严重程度与外周血IL-17A水平呈正相关关系(r=0.591，P＜0.001)。外周血IL-17A水平预测痤疮瘢痕发生的灵敏度为84.00%，特异度为83.80%。结论外周血IL-17A水平与寻常痤疮严重程度及痤疮瘢痕严重程度密切相关，对痤疮瘢痕有良好的预测价值。
- 寻常痤疮 /
- 白介素17A /
- 痤疮瘢痕 /
- 预测 /
- 相关性研究
Abstract: Objective To investigate the correlation between interleukin 17A (IL-17A) in peripheral blood and the severity of acne vulgaris, and its predictive value for acne scars. Methods From October 2022 to October 2023, a total of 130 patients with acne vulgaris who were treated at the Department of Dermatology of Anhui Provincial Hospital were divided into mild-to-moderate group (45 cases), severe group (40 cases), and extremely severe group (45 cases). Forty healthy examinees were selected as the control group. According to the severity of scar, the observation group was divided into non-scar group (25 cases), mild scar group (25 cases), moderate scar group (40 cases) and severe scar group (40 cases). IL-17A levels of peripheral blood were detected by Enzyme linked immunosorbent assay. Results The peripheral blood IL-17A of mild and moderate group, severe group, and severe and extreme group in acne vulgaris patients were significantly higher than that of the healthy control group (P < 0.05). The severity of acne was positively correlated with the level of IL-17A in peripheral blood (r=0.724, P < 0.001). The levels of IL-17A in peripheral blood of patients with mild, moderate, and severe acne scars gradually increased and were significantly higher than the non-scar group (P < 0.05). Spearman analysis showed that the severity of acne scars was positively correlated with the level of IL-17A in peripheral blood (r=0.591, P < 0.001). The sensitivity of peripheral blood IL-17A level in predicting the occurrence of acne scars was 84.00%, and the specificity was 83.80%. Conclusion Peripheral blood IL-17A level is closely related to the severity of acne vulgaris and acne scars, and has good predictive value for acne scars.
- Acne vulgaris /
- IL-17A /
- Acne scarring /
- Prediction /
- Correlation study
利益冲突 无

HTML全文

图 1 外周血IL-17A预测痤疮瘢痕的ROC曲线

Figure 1. ROC curve of peripheral blood IL-17A in predicting acne scars

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表 1 不同严重程度痤疮患者与健康对照组一般资料及IL-17A水平比较

Table 1. Comparison of general data and IL-17A levels among acne patients with varying severity and healthy controls

组别	例数	性别(男/女，例)	年龄(x±s，岁)	IL-17A (x±s，pg/mL)
健康对照组	40	21/19	22.61±2.25	7.86±4.00
轻中度痤疮组	45	17/28	23.50±2.61	14.51±6.01
重度痤疮组	40	18/22	22.88±3.67	20.98±6.35
极重度痤疮组	45	16/29	22.48±2.90	25.35±7.99
统计量		3.039^a	1.302^b	76.844^b
P值		0.386	0.279	＜0.001
注：^a为χ²值，^b为F值。

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表 2 不同严重程度痤疮瘢痕患者一般资料及IL-17A水平比较

Table 2. Comparison of general data and IL-17A levels among acne patients with varying severity

组别	例数	性别(男/女，例)	年龄(x±s，岁)	IL-17A (x±s，pg/mL)
无瘢痕组	25	9/16	23.33±4.11	12.15±4.78
轻度瘢痕组	25	13/12	22.84±2.00	17.62±5.87
中度瘢痕组	40	16/24	23.05±3.19	21.61±7.20
重度瘢痕组	40	13/27	22.70±2.83	25.60±7.54
统计量		2.589^a	0.191^b	22.712^b
P值		0.459	0.902	＜0.001
注：^a为χ²值，^b为F值。

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