情绪、元认知及血清miRNAs对抑郁症患者疾病恐惧的影响

冯彩琴; 郑吉锋

doi:10.16766/j.cnki.issn.1674-4152.003673

情绪、元认知及血清miRNAs对抑郁症患者疾病恐惧的影响

doi: 10.16766/j.cnki.issn.1674-4152.003673

冯彩琴^,,
郑吉锋

绍兴市第七人民医院康复精神科，浙江绍兴 312000

基金项目:

浙江省医药卫生科技计划项目 2024KY1735

详细信息

通讯作者:
冯彩琴，E-mail：fcq15157503298@163.com

中图分类号: R749.4
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- 文章访问数: 29
- HTML全文浏览量: 13
- PDF下载量: 3
- 被引次数: 0
出版历程
- 收稿日期: 2024-04-29

Effects of emotional state, metacognition, and serum miRNAs on disease fear in depressed patients

FENG Caiqin^,,
ZHENG Jifeng

Rehabilitation Psychiatry, Shaoxing Seventh People's Hospital, Shaoxing, Zhejiang 312000, China

摘要

摘要: 目的分析抑郁症患者情绪、元认知以及血清miRNA-134、miRNA-16水平，探讨影响抑郁症患者疾病恐惧的因素。方法选取绍兴市第七人民医院2022年9月—2024年1月治疗的首发未用药抑郁症患者142例，按照恐惧疾病进展简化量表(FoP-Q-SF)评分将患者分为高恐惧组(79例)和低恐惧组(63例)。比较2组患者基线资料、情绪、元认知和血清miR-134、miR-16表达水平；采用logistic回归分析评估影响抑郁症患者疾病恐惧的因素。结果高恐惧组患者汉密尔顿抑郁量表(HAMD-17)评分、汉密尔顿焦虑量表(HAMA-14)评分和无认知问卷(MCQ-30)评分均高于低恐惧组(P＜0.05)；血清miRNA-134、miRNA-16水平均低于低恐惧组(P＜0.05)；2组患者性别、年龄、就业状态、独居、抑郁家族史及睡眠时长比较差异均有统计学意义(P＜0.05)。Logistic回归分析结果显示，影响抑郁症患者疾病恐惧的因素包括独居、MCQ-30评分、血清miRNA-134和miRNA-16水平(OR=8.149、1.094、＜0.001、＜0.001)。结论元认知水平和血清miR-134、miR-16表达水平对抑郁症患者疾病恐惧具有显著影响。
- 抑郁症 /
- 元认知 /
- 微小核糖核酸 /
- 疾病恐惧 /
- 影响因素
Abstract: Objective To explore the relationship between emotional state, metacognition, and serum levels of miRNA-134 and miRNA-16 with disease fear in patients with depression. Methods A total of 142 patients with first-episode, medication-free depression treated at Shaoxing Seventh People's Hospital from September 2022 to January 2024 were selected. According to the fear of progression questionnaire-short form (FoP-Q-SF) score, the patients were divided into a high fear group (79 cases) and a low fear group (63 cases). The baseline data, emotional state, metacognition, and serum levels of miRNA-134 and miRNA-16 were compared between the two groups. Logistic regression analysis was used to evaluate the factors affecting the fear of disease in patients with depression. Results The scores of Hamilton depression scale-17 (HAMD-17), Hamilton anxiety scale-14 (HAMA-14), and the metacognitions questionnaire-30 (MCQ-30) in the high fear group were significantly higher than those in the low fear group (P < 0.05). The serum levels of miRNA-134 and miRNA-16 were significantly lower than those in the low fear group (P < 0.05). Additionally, there were significant differences in gender, age, employment status, living alone, family history of depression, and sleep duration between the two groups (P < 0.05). Logistic regression analysis identified living alone, MCQ-30 score, serum levels of miRNA-134 and miRNA-16 as significant factors affecting disease fear, with OR values of 8.149, 1.094, < 0.001, and < 0.001, respectively. Conclusion Metacognition levels and serum expression of miRNA-134 and miRNA-16 significantly impact the fear of disease in patients with depression.
- Depressive disorder /
- Metacognition /
- Micro ribonucleic acids /
- Disease fear /
- Influencing factors
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表 1 2组抑郁症患者基线资料比较

Table 1. Comparison of baseline data between two groups of patients with depression

组别	例数	性别[例(%)]		年龄[M(P₂₅, P₇₅)，岁]	受教育程度[例(%)]			户籍[例(%)]
组别	例数	男性	女性	年龄[M(P₂₅, P₇₅)，岁]	初中以下	高中/中专	大专以上	城市	农村
高恐惧组	79	25(31.65)	54(68.35)	30.00(25.00，37.00)	46(58.23)	20(25.32)	13(16.45)	34(43.04)	45(56.96)
低恐惧组	63	31(49.21)	32(50.79)	26.00(24.00，32.00)	31(49.21)	14(22.22)	18(28.57)	31(49.21)	32(50.79)
统计量		4.525^a		-2.585^b	3.023^b			0.537^a
P值		0.033		0.010	0.221			0.464

组别	例数	婚姻状况[例(%)]			就业状态[例(%)]			独居[例(%)]
组别	例数	未婚	已婚	离婚/丧偶	在职	无业/退休		是	否
高恐惧组	79	22(27.85)	36(45.57)	21(26.58)	26(32.91)	53(67.09)		44(55.70)	35(44.30)
低恐惧组	63	21(33.33)	31(49.21)	11(17.46)	33(52.38)	30(47.62)		23(36.51)	40(63.49)
统计量		1.741^a			5.471^a			5.178^a
P值		0.419			0.019			0.023
注：^a为χ²值，^b为U值。

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表 2 2组抑郁症患者疾病与健康状态比较

Table 2. Comparison of disease and health status between two groups of patients with depression

组别	例数	BMI(x±s)	抑郁症家族史[例(%)]		睡眠时长[例(%)]
组别	例数	BMI(x±s)	是	否	≤6 h	＞6 h
高恐惧组	79	22.17±2.62	27(34.18)	52(65.82)	59(74.68)	20(25.32)
低恐惧组	63	22.50±1.97	12(19.05)	51(80.95)	37(58.73)	26(41.27)
统计量		0.874^a	4.027^b		4.073^b
P值		0.384	0.045		0.044
注：^a为t值，^b为χ²值。

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表 3 2组抑郁症患者情绪、元认知及血清miRNA-134、miRNA-16水平比较

Table 3. Comparison of emotion, metacognition, and serum levels of miRNA-134, miRNA-1 between two groups of patients with depression

组别	例数	HAMD-17评分[M(P₂₅, P₇₅)，分]	HAMA-14评分(x±s，分)	MCQ-30评分(x±s，分)	血清miRNAs[M(P₂₅, P₇₅)]
组别	例数	HAMD-17评分[M(P₂₅, P₇₅)，分]	HAMA-14评分(x±s，分)	MCQ-30评分(x±s，分)	miRNA-134	miRNA-16
高恐惧组	79	27.00(24.00，31.00)	21.97±5.52	70.30±14.64	0.31(0.27，0.35)	0.03(0.02，0.04)
低恐惧组	63	25.00(21.00，27.00)	18.49±4.82	57.70±11.65	0.44(0.39.0.50)	0.04(0.03，0.05)
统计量		-2.515^a	3.951^b	5.570^b	-8.618^a	-4.611^a
P值		0.120	＜0.001	＜0.001	＜0.001	＜0.001
注：^a为U值，^b为t值。

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表 4 情绪、元认知及血清miRNAs对抑郁症患者疾病恐惧的影响分析(n=142)

Table 4. Effects of emotion, metacognition, and serum miRNAs on disease-related fear in patients with depression(n=142)

变量	B	SE	Waldχ²	P值	OR值	95% CI
独居	2.098	0.889	5.561	0.018	8.149	1.426~46.568
MCQ-30评分	0.090	0.035	6.595	0.010	1.094	1.022~1.172
miRNA-134	-41.040	9.657	18.384	＜0.001	＜0.001	＜0.001~＜0.001
miRNA-16	-108.711	40.109	7.346	0.007	＜0.001	＜0.001~＜0.001

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