血清KLF2、S1P1水平与川崎病患儿冠状动脉损伤的相关性研究

夏琨; 张勇; 周丹

doi:10.16766/j.cnki.issn.1674-4152.003718

血清KLF2、S1P1水平与川崎病患儿冠状动脉损伤的相关性研究

doi: 10.16766/j.cnki.issn.1674-4152.003718

华中科技大学同济医学院附属武汉儿童医院，湖北武汉 430019

基金项目:

湖北省卫生健康委员会科研项目 WJ2021M019

详细信息

通讯作者:
周丹，E-mail: zhoudan@zgwhfe.com

中图分类号: R725.4
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- 文章访问数: 17
- HTML全文浏览量: 13
- PDF下载量: 2
- 被引次数: 0
出版历程
- 收稿日期: 2024-05-11
- 网络出版日期: 2024-12-28

The correlation between serum KLF2 and S1P1 levels and coronary artery injury in children with Kawasaki disease

Wuhan Children ' s Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430019, China

摘要

摘要: 目的探究锌指样转录因子2(KLF2)、1磷酸鞘氨醇受体1(S1P1)水平与川崎病患儿冠状动脉损伤的相关性，以及冠状动脉损伤发生的相关危险因素。方法选择华中科技大学同济医学院附属武汉儿童医院2021年12月—2023年12月收治的120例川崎病患儿作为研究对象，检测血清KLF2、S1P1水平，评估患儿是否存在冠状动脉损伤及其程度，分析血清KLF2、S1P1水平与冠状动脉损伤之间的关系。结果冠状动脉损伤患儿血清KLF2、S1P1水平低于无冠状动脉损伤[(2.48±0.72)pg/mL vs. (4.29±0.92)pg/mL；(287.65±42.88)ng/mL vs. (427.64±52.86)ng/mL，P＜0.01]；冠状动脉扩张组血清KLF2、S1P1水平高于小中型冠状动脉瘤组、巨大冠状动脉瘤组患儿，小中型冠状动脉瘤组血清KLF2、S1P1水平高于巨大冠状动脉瘤组患儿；血清KLF2、S1P1水平与冠状动脉损伤程度呈负相关关系(r=-0.522、-0.634，P=0.003、＜0.001)；多元logistic回归分析，结果显示发热病程、白细胞计数、KLF2、S1P1均为患儿冠状动脉损伤的影响因素(P＜0.05)。结论川崎病冠状动脉损伤患儿血清KLF2、S1P1水平下降，且下降程度与冠状动脉损伤程度密切相关，发热病程、白细胞计数、KLF2、S1P1水平是患者冠状动脉损伤的影响因素。
- 川崎病 /
- 冠状动脉损伤 /
- 锌指样转录因子2 /
- 1磷酸鞘氨醇受体1
Abstract: Objective To explore the correlation between Krüppel-like transcription factor 2 (KLF2) and sphingosine 1-phosphate receptor 1 (S1P1) levels and coronary artery injury in children with Kawasaki disease, and the risk factors for coronary artery injury. Methods A total of 120 children with Kawasaki disease admitted to Wuhan Children ' s Hospital, Tongji Medical College, Huazhong University of Science and Technology from December 2021 to December 2023 were studied. Serum KLF2 and S1P1 levels were determined, the presence and the degree of coronary artery injury were assessed, and the correlation among serum KLF2, S1P1 levels, and coronary artery injury was analyzed. Results The levels of serum KLF2 and S1P1 in children with coronary artery injury were lower than those without injury [(2.48±0.72) vs. (4.29±0.92) pg/mL, (287.65±42.88) vs. (427.64±52.86) ng/mL, P < 0.01]; The levels of serum KLF2 and S1P1 in coronary dilatation group were higher than those in small, medium and large coronary aneurysm group; The levels of serum KLF2 and S1P1 in the small and medium coronary aneurysm group were higher than those in the large coronary aneurysm group; Serum KLF2 and S1P1 levels were negatively correlated with the degree of coronary artery injury (r=-0.522, -0.634; P=0.003, P < 0.001); Multiple Logistic regression analysis showed the duration of fever, white blood cell count, KLF2 and S1P1 were the influencing factors of coronary artery injury in children (P < 0.05). Conclusion The levels of serum KLF2 and S1P1 in children with Kawasaki disease with coronary artery injury decrease, and the decreased degree is closely related to the degree of coronary artery injury. The course of fever duration, white blood cell count, and the levels of KLF2 and S1P1 are influential factors for coronary artery injury.
- Kawasaki disease /
- Coronary artery injury /
- Krüppel-like transcription factor 2 /
- Sphingosine 1-phosphate receptor 1

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表 1 冠状动脉损伤与无冠状动脉损伤患儿血清KLF2、S1P1水平比较(x±s)

Table 1. Comparison of serum KLF2 and S1P1 levels in children with coronary artery injury and without coronary artery injury(x±s)

组别	例数	KLF2(pg/mL)	S1P1(ng/mL)
冠状动脉损伤	43	2.48±0.72	287.65±42.88
无冠状动脉损伤	77	4.29±0.92	427.64±52.86
t值		11.130	14.844
P值		＜0.001	＜0.001

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表 2 不同冠状动脉损伤程度患儿血清KLF2、S1P1水平比较(x±s)

Table 2. Comparison of serum KLF2 and S1P1 levels in children with different degrees of coronary artery injury(x±s)

组别	例数	KLF2(pg/mL)	S1P1(ng/mL)
冠状动脉扩张组	24	2.66±0.55	306.84±34.25
小中型冠状动脉瘤组	12	2.55±0.32^a	271.64±40.26^a
巨大冠状动脉瘤组	7	1.74±1.23^ab	249.3±41.25^ab
F值		5.417	8.073
P值		0.008	＜0.001
注：与冠状动脉扩张组比较，^aP＜0.05；与冠状动脉扩张组比较，^bP＜0.05。

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表 3 冠状动脉损伤与无冠状动脉损伤患儿各项资料比较

Table 3. Comparison of data of children with coronary artery injury and without coronary artery injury

指标	冠状动脉损伤(n=43)	无冠状动脉损伤(n=77)	统计量	P值
性别[例(%)]			0.767^a	0.381
男	21(48.84)	44(57.14)
女	22(51.16)	33(42.86)
体温(x±s，℃)	38.25±1.06	38.08±1.02	0.863^b	0.390
体重指数(x±s)	15.26±2.75	15.37±2.63	0.216^b	0.829
年龄(x±s，岁)	3.06±0.98	3.28±1.01	1.040^b	0.300
发热病程(x±s，d)	8.26±1.09	7.33±1.13	4.419^b	＜0.001
川崎病类型[例(%)]			0.589^a	0.443
典型	29(67.44)	57(74.03)
不完全	14(32.56)	20(25.97)
血小板计数(x±s，×10⁹/L)	412.86±32.87	395.66±28.53	2.997^b	0.003
白细胞计数(x±s，×10⁹/L)	15.64±3.84	12.88±3.95	3.707^b	＜0.001
淋巴细胞计数(x±s，×10⁹/L)	3.35±0.98	3.42±0.95	0.383^b	0.703
血沉(x±s，mm/h)	70.65±10.81	68.22±9.75	1.259^b	0.211
红细胞平均分布宽度(x±s，%)	13.85±1.65	13.57±1.51	0.891^b	0.375
注：^a为χ²值，^b为t值。

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表 4 冠状动脉损伤影响因素多元logistic分析

Table 4. Multivariate analysis of influencing factors of coronary artery injury

变量	B	SE	Waldχ²	P值	OR值	95% CI
发热病程	0.376	0.155	5.885	0.016	1.456	1.075~1.973
白细胞计数	0.476	0.216	4.856	0.028	1.610	1.054~2.458
血小板计数	0.507	0.289	3.078	0.080	1.660	0.942~2.925
KLF2	0.534	0.177	9.102	0.028	1.706	1.206~2.413
S1P1	0.507	0.187	7.351	0.003	1.660	1.151~2.395

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