基于文献计量学和可视化分析的肿瘤焦亡全球研究趋势

梁博; 袁丁; 王建业; 周少龙; 刘荣俊; 王新军

doi:10.16766/j.cnki.issn.1674-4152.003733

基于文献计量学和可视化分析的肿瘤焦亡全球研究趋势

doi: 10.16766/j.cnki.issn.1674-4152.003733

1.
郑州大学第五附属医院神经外科，河南郑州 450052
2.
郑州大学第一附属医院急诊医学科，河南郑州 450052
3.
郑州大学第三附属医院神经外科，河南郑州 450052

基金项目:

国家自然科学基金项目 81972361

河南省医学科技攻关计划项目 LHGJ20200477

河南省重点研发与推广专项 222102310039

详细信息

通讯作者:
王新军，E-mail：wangxj@zzu.edu.cn

中图分类号: R730.2
计量
- 文章访问数: 31
- HTML全文浏览量: 11
- PDF下载量: 3
- 被引次数: 0
出版历程
- 收稿日期: 2024-02-01
- 网络出版日期: 2024-12-28

Global research trends of pyroptosis in tumor based on bibliometrics and visualization analysis

1.
Department of Neurosurgery, the Fifth Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China

摘要

摘要: 目的通过文献计量学的分析手段，对肿瘤焦亡领域的研究进行全面梳理和分析，揭示全球范围内肿瘤焦亡研究的热点分布，并据此推测该领域未来的发展方向和趋势。方法检索2007年1月1日—2023年12月31日期间Web of Science数据库中收录的关于肿瘤焦亡的英文文献。利用VOSviewer和CiteSpace这两款可视化分析软件，对这些文献进行多维度分析。结果共纳入2 709篇文献。该领域的发文量于2019年后呈爆发式增长，发文量前三位的国家是中国、美国和德国。最多产的10位作者中有6位来自中国。此外，排名前五的出版物中有3份来自Frontiers系列期刊。关键词分析显示2020年之前主要集中在机制和途径方面，如“NLRP3炎症小体”“自噬”“NF-Kappa-B”“途径”和“增殖”等，而近期，“肿瘤微环境”“预后”“治疗”“生存”“顺铂”“化疗”和“免疫治疗”等关键词开始频繁出现。结论肿瘤焦亡已经成为全球范围内的研究热点，其在抗癌和促癌过程中的重要作用逐渐受到研究者的关注。随着对肿瘤中焦亡机制的深入探索，有理由相信，其将对未来的肿瘤治疗产生深远的影响。
- 焦亡 /
- 肿瘤 /
- 程序性细胞死亡 /
- 文献计量学 /
- 可视化分析
Abstract: Objective Through bibliometric analysis, comprehensively review and analyze research in the field of tumor pyroptosis, revealing the global distribution of research hotspots in this area. Based on this, speculate on the future development directions and trends in this field. Methods Retrieve english-language literature on tumor pyroptosis from the Web of Science database from January 1, 2007 to December 31, 2023. Use VOSviewer and CiteSpace for multi-dimensional analysis. Results A total of 2 709 articles were included in the analysis. The volume of publications in the field showed explosive growth after 2019. The top three countries in terms of publication volume were China, the United States and Germany. Among the top 10 most productive authors, 6 were from China. In addition, three of the top five publications came from Frontiers journals. The keyword analysis showed that before 2020, the focus was mainly on mechanisms and pathways such as "NLRP3 inflammasome" "autophagy" "NF-Kappa-B" "pathways" and "proliferation". However, in recent years, keywords such as "tumor microenvironment" "prognosis" "treatment" "survival" "cisplatin" and "immunotherapy" have begun to appear frequently. Conclusion Tumor pyroptosis has become a global research hotspot, and its crucial role in both anticancer and cancer-promoting processes is gradually attracting the attention of researchers. With the deepening exploration of the mechanisms of tumor pyroptosis, we have reason to believe that it will have a profound impact on the future of tumor treatment.
- Pyroptosis /
- Tumor /
- Programmed cell death /
- Bibliometrics /
- Visualization analysis

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图 1 2007—2023年肿瘤焦亡研究领域发文量及引用频次的趋势

Figure 1. Trends and citation frequency of tumor pyroptosis publications from 2007 to 2023

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图 2 Trends and citation frequency of tumor pyroptosis publications from 2007 to 2023

注：A为全球肿瘤焦亡相关文献发表国家的地理分布图；B为跨国合作可视化图；C为国家之间引文的网络可视化图。

Figure 2. Visualization of global country distribution and collaboration network for cancer pyrodeath research

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图 3 机构合作与影响力可视化分析图

注：A为发表肿瘤焦亡文献最多的前20家机构；B为发文机构文献被引用次数最多的前20家机构；C为发表肿瘤焦亡文献最多的前20家资助机构；D为发文机构之间引文的网络可视化图。

Figure 3. A visual analysis of institutional cooperation and influence

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图 4 被引频次爆发性最强的前25篇参考文献

Figure 4. The top 25 references with the strongest cited frequency explosion

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图 5 关键词多维度可视化分析图

注：A为关键词网络可视化图；B为关键词叠加可视化图(颜色为出现年份)；C为关键词的密度可视化图；D为被引频次爆发性最强的前15个关键词。

Figure 5. Keywords Multi-dimensional visual analysis diagram

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表 1 肿瘤焦亡领域发表论文最多的10个国家论文发表情况

Table 1. The top 10 most productive countries with publications in tumor pyroptosis

排序	国家	发文量	比例	总被引频次	文章平均被引频次	TLS
1	China	1 939	71.58	51 797	26.71	17 769
2	USA	530	19.56	53 206	100.39	12 934
3	Germany	78	2.88	8 452	108.35	1 990
4	Australia	61	2.25	9 106	149.28	2 061
5	Japan	59	2.18	3 075	52.12	1 010
6	France	52	1.92	5 961	114.63	1 383
7	UK	52	1.92	8 292	159.46	1 069
8	South Korea	40	1.48	937	23.43	496
9	Spain	39	1.44	2 154	55.23	1 147
10	Switzerland	35	1.29	5 768	164.8	1 448

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表 2 肿瘤焦亡领域发文量排名前10位作者发文情况

Table 2. The publication status of the top 10 authors in the field of tumor scorch death

排序	作者	发文量	总被引频次	TLS	国家
1	KANNEGANTI T D	32	4 330	53	USA
2	LIU Y	20	245	14	China
3	WANG W	19	339	13	China
4	MIAO E A	18	4 827	15	USA
5	SUN Z J	18	384	69	China
6	WU H	17	3 281	41	USA
7	ZHANG Y	17	332	15	China
8	CHEN Y	15	204	23	China
9	SHAO F	15	12 322	38	China
10	BACHOVCHIN D A	14	1 383	51	USA

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表 3 肿瘤焦亡研究发文量排名前10的期刊发文情况

Table 3. The number of publications in the top 10 journals in the study of tumor pyrodeath

排序	期刊	发文量	总被引频次	IF	TLS
1	Frontiers in Immunology	110	1 935	7.3	1 185
2	Frontiers in Oncology	77	883	4.7	1 100
3	Cell Death & Disease	58	2 896	9.0	1 123
4	Frontiers in Cell and Developmental Biology	56	905	5.5	694
5	International Journal of Molecular Sciences	51	1 163	5.6	500
6	Frontiers in Genetics	47	211	3.7	540
7	Frontiers in Pharmacology	39	398	5.6	365
8	International Immunopharmacology	32	263	5.6	311
9	Scientific Reports	32	605	4.6	331
10	Cancers	29	560	5.2	434

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表 4 肿瘤焦亡相关的引用最多的前5篇文章及内容

Table 4. The top 5 most cited articles and contents related to tumor pyrodeath

题目	第一作者	期刊	发表年份	总被引频次
Gasdermin E suppresses tumour growth by activating anti-tumour immunity	ZHANG Z B	Nature	2020	805
Pyroptosis: A new frontier in cancer	FANG Y	Biomedicine & Pharmacotherapy	2020	532
The role of pyroptosis in cancer: pro-cancer or pro-host?	XIA X J	Cell Death & Disease	2019	520
PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis	HOU J W	Nature Cell Biology	2020	469
Role of the NLRP3 inflammasome in cancer	MOOSSAVI M	Molecular Cancer	2018	299

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