自拟清肝明目生津润燥汤超声雾化治疗肝肾阴虚型干眼症的效果观察

张国英; 杜成春; 官文清

doi:10.16766/j.cnki.issn.1674-4152.003771

自拟清肝明目生津润燥汤超声雾化治疗肝肾阴虚型干眼症的效果观察

doi: 10.16766/j.cnki.issn.1674-4152.003771

1.
杭州市临平区中西医结合医院眼科，浙江杭州 311100
2.
杭州市临平区中西医结合医院科教科

基金项目:

浙江省中医药科学研究基金项目 2020ZB206

详细信息

通讯作者:
官文清，E-mail：526750007@qq.com

中图分类号: R777.34 R276.7
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- 文章访问数: 16
- HTML全文浏览量: 9
- PDF下载量: 1
- 被引次数: 0
出版历程
- 收稿日期: 2024-06-06
- 网络出版日期: 2024-12-31

Observation on the effect of self-made Qinggan Mingmu Shengjin Runzao Tang ultrasonic atomization therapy on dry eye syndrome of liver and kidney yin deficiency type

1.
Department of Ophthalmology, Linping District Integrated Traditional Chinese and Western Medicine Hospital, Hangzhou 311100, Zhejiang, China

摘要

摘要: 目的探讨自拟清肝明目生津润燥汤超声雾化治疗肝肾阴虚型干眼症的效果。方法将2023年10月—2024年3月杭州市临平区中西医结合医院收治的158例肝肾阴虚型干眼症患者按照治疗方法分成对照组与观察组，对照组79例予以常规治疗，观察组79例在对照组基础上予以自拟清肝明目生津润燥汤超声雾化治疗，均治疗4周。观察2组患者中医证候积分、睑板腺功能、泪膜破裂时间(BUT)、泪河高度、角膜荧光素染色(FL)评分、临床疗效。结果观察组治疗后中医证候积分的各项评分均低于对照组(P＜0.05)。观察组治疗后睑板腺功能的各项评分均低于对照组(P＜0.05)。观察组治疗后的BUT[(9.55±1.44)s]、泪河高度[(0.24±0.06)mm]大于对照组[(8.36±1.53)s、(0.21±0.05)mm，均P＜0.001]；FL评分低于对照组[(3.83±1.00)分vs. (4.53±1.12)分，P＜0.001]。观察组总有效率为94.94%(75/79)，高于对照组[82.28%(65/79)，χ²=6.270，P=0.012]。结论自拟清肝明目生津润燥汤超声雾化治疗能在常规治疗基础上进一步改善肝肾阴虚型干眼症患者睑板腺功能，可明显减轻患者症状，提高泪膜稳定性。
- 干眼症 /
- 清肝明目生津润燥汤 /
- 超声雾化治疗 /
- 肝肾阴虚型 /
- 中医证候积分 /
- 睑板腺功能
Abstract: Objective To explore the effect of self formulated Qinggan Mingmu Shengjin Runzao Tang ultrasonic atomization therapy on dry eye syndrome of liver and kidney yin deficiency type. Methods A total of 158 patients with liver and kidney-yin deficiency type dry eye syndrome admitted to our hospital from October 2023 to March 2024 were voluntarily divided into a control group and an observation group. Seventy-nine patients in the control group received routine treatment, while 79 patients in the observation group received self-designed Qinggan Mingmu Shengjin Runzao Tang ultrasonic nebulization treatment on the basis of the control group, all of them were treated for 4 weeks. The traditional chinese medicine (TCM) syndrome scores, meibomian gland function, tear film rupture time (tear film break up time, BUT), tear river height, corneal fluorescein staining (fluorescent, FL) score, and clinical efficacy were observed in the two groups. Results After treatment, the various scores of traditional Chinese medicine syndrome scores in the observation group were lower than those in the control group (P < 0.05). The various scores of meibomian gland function in the observation group after treatment were lower than those in the control group (P < 0.05). The post-treatment BUT and tear stream height in the observation group (9.55±1.44) s, (0.24±0.06) mm were higher than those in the control group (8.36±1.53) s, (0.21±0.05) mm, both P < 0.001; The FL score (3.83±1.00) points was lower than that of the control group (4.53 ±1.12) points (P < 0.001). The total effective rate of the observation group was 94.94% (75/79), which was higher than the 82.28% (65/79) of the control group (χ²=6.270, P=0.012). Conclusion The self-designed Qinggan Mingmu Shengjin Runzao Tang ultrasonic nebulization treatment can further improve the meibomian gland function of patients with liver and kidney-yin deficiency type dry eye syndrome on the basis of conventional treatment, significantly reduce patient symptoms, and improve tear film stability.
- Dry eye syndrome /
- Qinggan Mingmu Shengjin Runzao Tang /
- Ultrasound nebulization therapy /
- Liver and kidney yin deficiency type /
- Traditional Chinese medicine syndrome integral /
- Meibomian gland function

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表 1 2组干眼症患者中医症状积分比较(x±s，分)

Table 1. Comparison of Traditional Chinese Medicine symptom points (x±s, points)

组别	例数	眼部干涩隐痛		t值	P值	白睛赤脉		t值	P值	便秘		t值	P值
组别	例数	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值
对照组	79	2.46±0.35	1.35±0.27	22.319	＜0.001	2.16±0.47	1.46±0.32	10.942	＜0.001	1.94±0.34	0.92±0.21	22.686	＜0.001
观察组	79	2.49±0.33	1.03±0.20	33.629	＜0.001	2.20±0.45	1.08±0.22	19.874	＜0.001	1.96±0.31	0.74±0.14	31.879	＜0.001
统计量		0.554^a	15.423^b			0.546^a	13.952^b			0.386^a	10.188^b
P值		0.580	＜0.001			0.586	＜0.001			0.699	＜0.001

组别	例数	小便赤短				t值	P值	眦部白色泡沫样眼眵				t值	P值
组别	例数	治疗前		治疗后		t值	P值	治疗前		治疗后		t值	P值
对照组	79	2.20±0.51		1.51±0.35		9.915	＜0.001	2.16±0.35		1.24±0.20		20.285	＜0.001
观察组	79	2.22±0.48		1.18±0.25		17.080	＜0.001	2.18±0.33		0.99±0.13		29.821	＜0.001
统计量		0.254^a		16.623^b				0.370^a		17.907^b
P值		0.800		＜0.001				0.712		＜0.001
注：^a为t值，^b为F值。

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表 2 2组干眼症患者睑板腺功能比较(x±s，分)

Table 2. Comparison of Meibomian gland function between two groups of patients with dry eye syndrome (x±s, points)

组别	例数	睑板腺丢失面积		t值	P值	睑板腺开口		t值	P值	睑板腺分泌物		t值	P值	眼睑分泌腺体		t值	P值
组别	例数	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值
对照组	79	3.16±0.45	1.83±0.33	21.184	＜0.001	3.23±0.38	1.78±0.35	24.946	＜0.001	2.63±0.26	1.76±0.20	23.574	＜0.001	2.55±0.22	1.62±0.18	29.080	＜0.001
观察组	79	3.19±0.42	1.48±0.25	31.096	＜0.001	3.27±0.35	1.51±0.33	32.520	＜0.001	2.66±0.23	1.45±0.15	39.166	＜0.001	2.58±0.20	1.25±0.13	49.557	＜0.001
统计量		0.433^a	24.223^b			0.688^a	12.153^b			0.768^a	21.560^b			0.897^a	31.534^b
P值		0.665	＜0.001			0.492	＜0.001			0.444	＜0.001			0.371	＜0.001
注：^a为t值，^b为F值。

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表 3 2组干眼症患者BUT、泪河高度、FL评分比较(x±s)

Table 3. Comparison of BUT, tear meniscus height, and FL score in two groups of patients with dry eye syndrome (x±s)

组别	例数	BUT(s)		t值	P值	泪河高度(mm)		t值	P值	FL评分(分)		t值	P值
组别	例数	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值	治疗前	治疗后	t值	P值
对照组	79	5.15±1.09	8.36±1.53^a	15.188	＜0.001	0.16±0.04	0.21±0.05^a	6.941	＜0.001	7.68±1.51	4.53±1.12^a	14.892	＜0.001
观察组	79	5.11±1.12	9.55±1.44^a	21.632	＜0.001	0.15±0.05	0.24±0.06^a	10.242	＜0.001	7.72±1.48	3.83±1.00^a	19.357	＜0.001
统计量		0.227^a	15.252^b			1.388^a	12.383^b			0.168^a	13.907^b
P值		0.820	＜0.001			0.167	＜0.001			0.866	＜0.001
注：^a为t值，^b为F值。

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