Research hotspot of moyamoya disease: a visualized analysis based on CiteSpace software
-
摘要:
目的 基于CiteSpace对烟雾病相关文献进行检索及可视化分析，梳理该领域研究现状、研究热点及发展趋势，以期为后续的研究提供参考。 方法 计算机检索2011年1月1日—2023年8月21日Web of Science核心合集数据库中烟雾病相关文献。使用CiteSpace 6.2.R4对发文量、国家/地区分布、机构分布、作者分布、关键词等进行可视化分析。 结果 共纳入英文文献2 499篇，2011—2023年烟雾病外文发文量整体呈缓慢上升趋势，发文以中、日为代表的亚洲国家为主，首都医科大学、首尔大学、北海道大学是当前发文量前三的机构，排名靠前的作者多来自同一机构/国家，形成紧密的合作团队，但世界范围内的合作密度较小。目前，烟雾病相关研究主要集中在烟雾病发病机制、术式改进、术后并发症等领域。关键词共现分析显示颅内外搭桥术、临床特征、血管疾病中心性最强；关键词聚类涉及脑过度灌注综合征等血运重建术术后并发症、动脉自旋标记等检查技术、环指蛋白213等烟雾病发病机制；突现词分析显示自发性闭塞、软脑膜血管成形术、基因等为近年来研究热点。 结论 烟雾病发病原因、治疗手段对患者长期疗效和疾病进程的影响等问题仍然困扰着临床诊断和治疗。未来研究者可进一步关注烟雾病患者病变血管的病理生理改变并开展个案报道。 Abstract:Objective To search and visually analyze the literature related to moyamoya disease based on CiteSpace, and summarize the research status, research hotspot and development trend in this field, in order to provide reference for subsequent research. Methods The literature related to moyamoya disease in the core collection database of Web of Science from January 1, 2011 to August 21, 2023 was searched by computer. CiteSpace 6.2.R4 was used for visual analysis of various aspects including the number of publications, country/region distribution, institution distribution, author distribution, keywords, etc. Results A total of 2 499 articles in English were included, and the number of foreign publications on Moyamoya disease showed a slow rising trend from 2011 to 2023, mainly in Asian countries represented by China and Japan. Capital Medical University, Seoul National University and Hokkaido University were the top three institutions of the number of publications. Most of the top authors came from these institutions or countries, forming a close cooperating team. However, there is currently low intensity of cooperation around the world. At present, the research on moyamoya disease mainly focuses on its pathogenesis, improvement of surgical methods, and postoperative complications. Keyword co-occurrence analysis showed that intracranial and extracranial bypass, clinical features, and vascular disease centrality were the strongest areas. Key words clustering involved postoperative complications of revascularization such as cerebral hyperperfusion syndrome, arterial spin labeling and other examination techniques, and the pathogenesis of moyamoya disease such as ring finger protein 213. Emergent word analysis shows that spontaneous occlusion, pial angioplasty and gene are the hot topics in recent years. Conclusion The causes of moyamoya disease, the effects of treatment on the long-term curative effect, and the course of the disease are still puzzling clinical diagnosis and treatment. In the future, researchers can further pay attention to the pathophysiological changes in blood vessels in moyamoya disease patients and conduct case reports. -
Key words:
- Moyamoya disease /
- Visual analysis /
- Research hotspots
-
图 1 2011—2023年MMD相关研究发文量分布
Figure 1. Distribution of MMD-related research publications from 2011 to 2023
图 2 2011—2023年MMD相关研究国家间合作网络
Figure 2. MMD-related research inter-country cooperation network from 2011 to 2023
图 3 2011—2023年MMD相关研究机构间合作网络
Figure 3. MMD-related research inter-institutional collaboration network from 2011 to 2023
图 4 2011—2023年MMD相关研究作者间合作网络
Figure 4. Collaboration network among authors of MMD-related studies from 2011 to 2023
图 5 2011—2023年MMD相关研究关键词聚类图谱
Figure 5. Cluster map of MMD-related research keywords from 2011 to 2023
图 6 2011—2023年MMD相关研究关键词突现
Figure 6. Emerging keywords in MMD-related research from 2011 to 2023
表 1 2011—2023年MMD相关研究发文量前10位国家/地区
Table 1. Top 10 countries and regions in MMD-related research publications from 2011 to 2023
序号 国家 发文量 构成比 中心性 1 CHINA 652 26.09 0.12 2 JAPAN 616 24.65 0.19 3 USA 554 22.17 0.62 4 SOUTH KOREA 274 10.96 0.09 5 GERMANY 128 5.12 0.11 6 INDIA 85 3.40 0.01 7 CANADA 73 2.92 0.07 8 FRANCE 61 2.44 0.04 9 ENGLAND 58 2.32 0.16 10 SWITZERLAND 53 2.12 0.04 
下载: 导出CSV
表 2 2011—2023年MMD相关研究发文量前10位机构
Table 2. Top 10 countries and regions in MMD-related research publications from 2011 to 2023
序号 机构 发文量 构成比 中心性 1 Capital Medical University 182 7.28 0.40 2 Seoul National University 106 4.24 0.17 3 Hokkadio University 87 3.48 0.09 4 Stanford University 78 3.12 0.25 5 Kyoto University 78 3.12 0.22 6 Harvard University 72 2.88 0.06 7 Seoul National University Hospital 69 2.76 0.02 8 Tohoku University 67 2.68 0.05 9 Fudan university 62 2.48 0.02 10 National Cerebral﹠Cardiovascular Center-Japan 57 2.28 0.08
下载: 导出CSV
表 3 2011—2023年MMD相关研究发文量前10位作者
Table 3. Top 10 authors of MMD-related research publications from 2011 to 2023
序号 作者 单位 发文量 中心性 1 Zhang Dong Capital Medical University 99 0.00 2 Wang Rong Capital Medical University 81 0.03 3 Zhang Qian Capital Medical University 68 0.05 4 Fujimura Miki Hokkaido University 67 0.11 5 Zhang Yan Capital Medical University 64 0.01 6 Zhao Jizong University of Chinese Academy of Sciences 58 0.01 7 Houkin Kiyohiro Hokkaido University 55 0.06 8 Kuroda Satoshi Toyama University 51 0.06 9 Tominaga Teiji Tohoku University 50 0.08 10 Miyamoto Susumu Kyoto University 44 0.03
下载: 导出CSV
表 4 2011—2023年MMD相关研究高频关键词
Table 4. High frequency keywords in MMD-related research from 2011 to 2023
序号 频次 中心性 关键词 1 1 711 0.00 moyamoya disease 2 287 0.08 children 3 255 0.02 stroke 4 250 0.12 clinical features 5 243 0.02 revascularization 6 234 0.05 surgery 7 226 0.58 extracranial intrecranial bypass 8 178 0.05 cerebral blood flow 9 172 0.01 brain 10 158 0.10 vascular disorders
下载: 导出CSV
-
[1] 烟雾病治疗中国专家共识编写组. 烟雾病治疗中国专家共识[J]. 国际脑血管病杂志, 2019, 27(9): 645-650.Writing group for Chinese expert consensus statement on the diagnosis and treatment of moyamoya disease. Chinese expert consensus statement on the diagnosis and treatment of moyamoya disease[J]. International Journal of Cerebrovascular Diseases, 2019, 27(9): 645-650. [2] FUJIMURA M, TOMINAGA T, KURODA S, et al. 2021 Japanese Guidelines for the management of moyamoya disease: guidelines from the research committee on moyamoya disease and Japan Stroke Society[J]. Neurol Med Chir (Tokyo), 2022, 62(4): 165-170. doi: 10.2176/jns-nmc.2021-0382 [3] GONZALEZ N R, AMIN-HANJANI S, BANG O Y, et al. Adult moyamoya disease and syndrome: current perspectives and future directions: a scientific statement from the American Heart Association/American Stroke Association[J]. Stroke, 2023, 54(10): e465-e479. [4] SUN Y X, ZHOU G Y, FENG J N, et al. Incidence and prevalence of moyamoya disease in urban China: a nationwide retrospective cohort study[J]. Stroke Vasc Neurol, 2021, 6(4): 615-623. doi: 10.1136/svn-2021-000909 [5] GRAF J, SCHWITALLA J C, ALBRECHT P, et al. Misdiagnoses and delay of diagnoses in Moyamoya angiopathy: a large Caucasian case series[J]. J Neurol, 2019, 266(5): 1153-1159. doi: 10.1007/s00415-019-09245-9 [6] 雷霆, 张华楸, 黄逸民, 等. 烟雾病发病机制研究和诊疗进展[J]. 中华实验外科杂志, 2023, 40(9): 1698-1700.LEI T, ZHANG H Q, HUANG Y M, et al. Comentary on mechanical investigation and progress of therapeutic methods of Moyamoya disease[J]. Chinese Journal of Experimental Surgery, 2023, 40(9): 1698-1700. [7] IHARA M, YAMAMOTO Y, HATTORI Y, et al. Moyamoya disease: diagnosis and interventions[J]. Lancet Neurol, 2022, 21(8): 747-758. doi: 10.1016/S1474-4422(22)00165-X [8] ISHISAKA E, WATANABE A, MURAI Y, et al. Role of RNF213 polymorphism in defining quasi-Moyamoya disease and definitive moyamoya disease[J]. Neurosurg Focus, 2021, 51(3): E2. DOI: 10.3171/2021.5.FOCUS21182. [9] HIRUMA M, WATANABE N, MITSUMATSU T, et al. Clinical features of Moyamoya disease with Graves' disease: a retrospective study of 394, 422 patients with thyroid disease[J]. Endocr J, 2023, 70(2): 141-148. doi: 10.1507/endocrj.EJ22-0319 [10] JEONG W, SEONG G M, OH J H, et al. A case report of critical ischemic stroke in Moyamoya-like vasculopathy accompanied by systemic lupus erythematosus[J]. Encephalitis, 2022, 2(1): 24-27. doi: 10.47936/encephalitis.2021.00150 [11] BOLEM N, NGA V D W, CHOU N, et al. Coexisting Moyamoya syndrome and type 1 diabetes mellitus: a case report and review of the literature[J]. Asian J Neurosurg, 2020, 15(1): 194-197. doi: 10.4103/ajns.AJNS_218_19 [12] SHANG S L, ZHOU D, YA J Y, et al. Progress in moyamoya disease[J]. Neurosurg Rev, 2020, 43(2): 371-382. doi: 10.1007/s10143-018-0994-5 [13] KLEINDORFER D O, TOWFIGHI A, CHATURVEDI S, et al. 2021 Guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association/American Stroke Association[J]. Stroke, 2021, 52(7): e364-e467. [14] NGUYEN V N, MOTIWALA M, ELARJANI T, et al. Direct, indirect, and combined extracranial-to-intracranial bypass for adult Moyamoya disease: an updated systematic review and meta-analysis[J]. Stroke, 2022, 53(12): 3572-3582. doi: 10.1161/STROKEAHA.122.039584 [15] YU J, ZHANG J B, LI J L, et al. Cerebral hyperperfusion syndrome after revascularization surgery in patients with Moyamoya disease: systematic review and meta-analysis[J]. World Neurosurg, 2020, 135: 357-366. e4. DOI: 10.1016/j.wneu.2019.11.065. [16] 陈传玉, 邓克学, 邱峻, 等. 动脉自旋标记技术对缺血型和出血型烟雾病患者脑灌注情况的评估[J]. 中华全科医学, 2019, 17(12): 2001-2003, 2012. doi: 10.16766/j.cnki.issn.1674-4152.001112CHEN C Y, DENG K X, QIU J, et al. Evaluation of cerebral perfusion in patients with ischemic and hemorrhagic moyamoya disease by arterial spin labeling[J]. Chinese Journal of General Practice, 2019, 17(12): 2001-2003, 2012. doi: 10.16766/j.cnki.issn.1674-4152.001112 [17] LIU E H, LIU C Y, JIN L D, et al. Clinical value of the systemic immune-inflammation index in Moyamoya disease[J]. Front Neurol, 2023, 14: 1123951. DOI: 10.3389/fneur.2023.1123951. [18] WANG Q N, ZOU Z X, WANG X P, et al. Endothelial Progenitor cells induce angiogenesis: a potential mechanism underlying neovascularization in encephaloduroarteriosynangiosis[J]. Transl Stroke Res, 2021, 12(2): 357-365. doi: 10.1007/s12975-020-00834-9 [19] FEUGRAY G, MIRANDA S, DUCHEZ V L, et al. Endothelial progenitor cells in autoimmune disorders[J]. Stem Cell Rev Rep, 2023, 19(8): 2597-2611. doi: 10.1007/s12015-023-10617-y [20] TINELLI F, NAVA S, ARIOLI F, et al. Vascular remodeling in moyamoya angiopathy: from peripheral blood mononuclear cells to endothelial cells[J]. Int J Mol Sci, 2020, 21(16): 5763. DOI: 10.3390/ijms21165763. [21] GORLA G, GARROZZINI T, POLLACI G, et al. Increase of circulating endothelial progenitor cells and released angiogenic factors in children with Moyamoya arteriopathy[J]. Int J Mol Sci, 2023, 24(2): 1233. DOI: 10.3390/ijms24021233. [22] NAKAMURA H, SATO K, YOSHIMURA S, et al. Moyamoya disease associated with Graves' disease and down syndrome: a case report and literature review[J]. J Stroke Cerebrovasc Dis, 2021, 30(1): 105414. DOI: 10.1016/j.jstrokecerebrovasdis.2020.105414. [23] SLINGERLAND A L, KARSTEN M B, SMITH E R, et al. Two sides of a coin: case report of unilateral synangiosis and contralateral stroke highlighting consequences of disease progression and efficacy of revascularization in sickle cell disease-associated Moyamoya syndrome[J]. Acta Haematol, 2022, 145(4): 458-464. doi: 10.1159/000521361 -
点击查看大图
计量
- 文章访问数: 13
- HTML全文浏览量: 7
- PDF下载量: 1
- 被引次数: 0
